BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Nicotinamide riboside (NR) is a NAD + precursor exhibiting beneficial effects against aging. Here the authors demonstrate that orally administered NR increases NAD + levels in a diphasic manner and that bone marrow stromal cell antigen 1 plays a crucial role for NAD + synthesis from NR.

Guardado en:

Detalles Bibliográficos
Autores principales:	Keisuke Yaku, Sailesh Palikhe, Hironori Izumi, Tomoyuki Yoshida, Keisuke Hikosaka, Faisal Hayat, Mariam Karim, Tooba Iqbal, Yasuhito Nitta, Atsushi Sato, Marie E. Migaud, Katsuhiko Ishihara, Hisashi Mori, Takashi Nakagawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a876a5bfafc342e5ae46b26347552ed1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a876a5bfafc342e5ae46b26347552ed1
record_format	dspace
spelling	oai:doaj.org-article:a876a5bfafc342e5ae46b26347552ed12021-11-21T12:39:02ZBST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities10.1038/s41467-021-27080-32041-1723https://doaj.org/article/a876a5bfafc342e5ae46b26347552ed12021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27080-3https://doaj.org/toc/2041-1723Nicotinamide riboside (NR) is a NAD + precursor exhibiting beneficial effects against aging. Here the authors demonstrate that orally administered NR increases NAD + levels in a diphasic manner and that bone marrow stromal cell antigen 1 plays a crucial role for NAD + synthesis from NR.Keisuke YakuSailesh PalikheHironori IzumiTomoyuki YoshidaKeisuke HikosakaFaisal HayatMariam KarimTooba IqbalYasuhito NittaAtsushi SatoMarie E. MigaudKatsuhiko IshiharaHisashi MoriTakashi NakagawaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keisuke Yaku Sailesh Palikhe Hironori Izumi Tomoyuki Yoshida Keisuke Hikosaka Faisal Hayat Mariam Karim Tooba Iqbal Yasuhito Nitta Atsushi Sato Marie E. Migaud Katsuhiko Ishihara Hisashi Mori Takashi Nakagawa BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
description	Nicotinamide riboside (NR) is a NAD + precursor exhibiting beneficial effects against aging. Here the authors demonstrate that orally administered NR increases NAD + levels in a diphasic manner and that bone marrow stromal cell antigen 1 plays a crucial role for NAD + synthesis from NR.
format	article
author	Keisuke Yaku Sailesh Palikhe Hironori Izumi Tomoyuki Yoshida Keisuke Hikosaka Faisal Hayat Mariam Karim Tooba Iqbal Yasuhito Nitta Atsushi Sato Marie E. Migaud Katsuhiko Ishihara Hisashi Mori Takashi Nakagawa
author_facet	Keisuke Yaku Sailesh Palikhe Hironori Izumi Tomoyuki Yoshida Keisuke Hikosaka Faisal Hayat Mariam Karim Tooba Iqbal Yasuhito Nitta Atsushi Sato Marie E. Migaud Katsuhiko Ishihara Hisashi Mori Takashi Nakagawa
author_sort	Keisuke Yaku
title	BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
title_short	BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
title_full	BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
title_fullStr	BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
title_full_unstemmed	BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
title_sort	bst1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a876a5bfafc342e5ae46b26347552ed1
work_keys_str_mv	AT keisukeyaku bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT saileshpalikhe bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT hironoriizumi bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT tomoyukiyoshida bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT keisukehikosaka bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT faisalhayat bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT mariamkarim bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT toobaiqbal bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT yasuhitonitta bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT atsushisato bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT marieemigaud bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT katsuhikoishihara bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT hisashimori bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities AT takashinakagawa bst1regulatesnicotinamideribosidemetabolismviaitsglycohydrolaseandbaseexchangeactivities
_version_	1718418905683197952

BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Ejemplares similares