BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
Nicotinamide riboside (NR) is a NAD + precursor exhibiting beneficial effects against aging. Here the authors demonstrate that orally administered NR increases NAD + levels in a diphasic manner and that bone marrow stromal cell antigen 1 plays a crucial role for NAD + synthesis from NR.
Guardado en:
Autores principales: | Keisuke Yaku, Sailesh Palikhe, Hironori Izumi, Tomoyuki Yoshida, Keisuke Hikosaka, Faisal Hayat, Mariam Karim, Tooba Iqbal, Yasuhito Nitta, Atsushi Sato, Marie E. Migaud, Katsuhiko Ishihara, Hisashi Mori, Takashi Nakagawa |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/a876a5bfafc342e5ae46b26347552ed1 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
por: Joanna Ratajczak, et al.
Publicado: (2016) -
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
por: Samuel A. J. Trammell, et al.
Publicado: (2016) -
Nicotinamide riboside kinase structures reveal new pathways to NAD+.
por: Wolfram Tempel, et al.
Publicado: (2007) -
Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
por: Audrey Sambeat, et al.
Publicado: (2019) -
Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder
por: Maria Gerasimenko, et al.
Publicado: (2020)