Bone Marrow Hypocellularity in Patients with End-Stage Kidney Disease

Background. Anemia and pancytopenia are not uncommon in patients with chronic kidney disease (CKD). Nevertheless, there is insufficient literature analyzing bone marrow pathology in patients with CKD or end-stage kidney disease (ESKD) receiving dialysis. Methods. This observational cohort study incl...

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Autores principales:	Chia-Chen Hsieh, Ming-Jen Chan, Yi-Jiun Su, Jen-Fen Fu, I-Kuan Wang, Chao-Yu Chen, Cheng-Hao Weng, Wen-Hung Huang, Ching-Wei Hsu, Tzung-Hai Yen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bone marrow biopsy hypocellularity chronic kidney disease end-stage kidney disease Medicine R
Acceso en línea:	https://doaj.org/article/a877507bdb12410693cfc513e5c0c148
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spelling	oai:doaj.org-article:a877507bdb12410693cfc513e5c0c1482021-11-25T17:44:08ZBone Marrow Hypocellularity in Patients with End-Stage Kidney Disease10.3390/healthcare91114522227-9032https://doaj.org/article/a877507bdb12410693cfc513e5c0c1482021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1452https://doaj.org/toc/2227-9032Background. Anemia and pancytopenia are not uncommon in patients with chronic kidney disease (CKD). Nevertheless, there is insufficient literature analyzing bone marrow pathology in patients with CKD or end-stage kidney disease (ESKD) receiving dialysis. Methods. This observational cohort study included 22 patients with ESKD and 23 patients with CKD that received bone marrow biopsy and aspiration at Chang Gung Memorial Hospital. Demographic, hematological, and biochemical data were collected at the time of bone marrow study for analysis. Results. Bone marrow aspiration demonstrated that patients with ESKD had a lower percentage of blasts than patients with CKD (0.52 ± 0.84 versus 1.06 ± 0.78 %, <i>p</i> = 0.033). Bone marrow biopsy revealed that the overall incidence of hypocellular bone marrow was 55.6%. Furthermore, patients with ESKD had higher proportion of hypocellular bone marrow than patients with CKD (72.7% versus 39.1%, <i>p</i> = 0.023). In a multivariate logistic regression model, it was revealed that ESKD status (odds ratio 9.43, 95% confidence interval 1.66–53.63, <i>p</i> = 0.011) and megakaryocyte count within bone marrow (odds ratio 0.48, 95% confidence interval 0.29–0.79, <i>p</i> = 0.004) were significant predictors for bone marrow hypocellularity. Conclusion. Bone marrow hypocellularity is common in patients with kidney dysfunction. Hypocellular marrow occurs more frequently in patients with ESKD than patients with CKD.Chia-Chen HsiehMing-Jen ChanYi-Jiun SuJen-Fen FuI-Kuan WangChao-Yu ChenCheng-Hao WengWen-Hung HuangChing-Wei HsuTzung-Hai YenMDPI AGarticlebone marrowbiopsyhypocellularitychronic kidney diseaseend-stage kidney diseaseMedicineRENHealthcare, Vol 9, Iss 1452, p 1452 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone marrow biopsy hypocellularity chronic kidney disease end-stage kidney disease Medicine R
spellingShingle	bone marrow biopsy hypocellularity chronic kidney disease end-stage kidney disease Medicine R Chia-Chen Hsieh Ming-Jen Chan Yi-Jiun Su Jen-Fen Fu I-Kuan Wang Chao-Yu Chen Cheng-Hao Weng Wen-Hung Huang Ching-Wei Hsu Tzung-Hai Yen Bone Marrow Hypocellularity in Patients with End-Stage Kidney Disease
description	Background. Anemia and pancytopenia are not uncommon in patients with chronic kidney disease (CKD). Nevertheless, there is insufficient literature analyzing bone marrow pathology in patients with CKD or end-stage kidney disease (ESKD) receiving dialysis. Methods. This observational cohort study included 22 patients with ESKD and 23 patients with CKD that received bone marrow biopsy and aspiration at Chang Gung Memorial Hospital. Demographic, hematological, and biochemical data were collected at the time of bone marrow study for analysis. Results. Bone marrow aspiration demonstrated that patients with ESKD had a lower percentage of blasts than patients with CKD (0.52 ± 0.84 versus 1.06 ± 0.78 %, <i>p</i> = 0.033). Bone marrow biopsy revealed that the overall incidence of hypocellular bone marrow was 55.6%. Furthermore, patients with ESKD had higher proportion of hypocellular bone marrow than patients with CKD (72.7% versus 39.1%, <i>p</i> = 0.023). In a multivariate logistic regression model, it was revealed that ESKD status (odds ratio 9.43, 95% confidence interval 1.66–53.63, <i>p</i> = 0.011) and megakaryocyte count within bone marrow (odds ratio 0.48, 95% confidence interval 0.29–0.79, <i>p</i> = 0.004) were significant predictors for bone marrow hypocellularity. Conclusion. Bone marrow hypocellularity is common in patients with kidney dysfunction. Hypocellular marrow occurs more frequently in patients with ESKD than patients with CKD.
format	article
author	Chia-Chen Hsieh Ming-Jen Chan Yi-Jiun Su Jen-Fen Fu I-Kuan Wang Chao-Yu Chen Cheng-Hao Weng Wen-Hung Huang Ching-Wei Hsu Tzung-Hai Yen
author_facet	Chia-Chen Hsieh Ming-Jen Chan Yi-Jiun Su Jen-Fen Fu I-Kuan Wang Chao-Yu Chen Cheng-Hao Weng Wen-Hung Huang Ching-Wei Hsu Tzung-Hai Yen
author_sort	Chia-Chen Hsieh
title	Bone Marrow Hypocellularity in Patients with End-Stage Kidney Disease
title_short	Bone Marrow Hypocellularity in Patients with End-Stage Kidney Disease
title_full	Bone Marrow Hypocellularity in Patients with End-Stage Kidney Disease
title_fullStr	Bone Marrow Hypocellularity in Patients with End-Stage Kidney Disease
title_full_unstemmed	Bone Marrow Hypocellularity in Patients with End-Stage Kidney Disease
title_sort	bone marrow hypocellularity in patients with end-stage kidney disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a877507bdb12410693cfc513e5c0c148
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Bone Marrow Hypocellularity in Patients with End-Stage Kidney Disease

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