A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C.
<h4>Objective</h4>Two recent studies, in a Spanish and a Chinese population, point to an association between rheumatoid arthritis (RA) risk and the deletion of the Late Cornified Envelope (LCE) 3B and 3C genes (LCE3C_LCE3B-del), a known risk factor for psoriasis. We aimed to replicate th...
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2012
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oai:doaj.org-article:a87a4dd435414f628346d0e99f60b8d12021-11-18T07:26:59ZA replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C.1932-620310.1371/journal.pone.0032045https://doaj.org/article/a87a4dd435414f628346d0e99f60b8d12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22384135/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Two recent studies, in a Spanish and a Chinese population, point to an association between rheumatoid arthritis (RA) risk and the deletion of the Late Cornified Envelope (LCE) 3B and 3C genes (LCE3C_LCE3B-del), a known risk factor for psoriasis. We aimed to replicate these studies in a large Dutch cohort.<h4>Methods</h4>1039 RA cases and 759 controls were genotyped for LCE3C_LCE3B-del. Association analysis was performed for the complete cohort and after stratification for the serologic markers anti-cyclic citrullinated peptide and rheumatoid factor. A meta-analysis was performed combining our data with the Spanish and Chinese datasets, resulting in an analysis including 2466 RA cases and 2438 controls.<h4>Results</h4>In the Dutch cohort we did not observe a significant association of LCE3C_LCE3B-del (p = 0.093) with RA risk. A stratified analysis for the serologic positive and negative group did not show an association between the genetic variant and disease risk, either. The meta-analysis, however, confirmed a significant association (p<0.0001, OR = 1.31, 95% confidence interval 1.16-1.47).<h4>Conclusion</h4>Our meta-analysis confirms the association of the LCE3 deletion with RA, suggesting that LCE3C_LCE3B-del is a common risk factor for (auto)immune diseases.Judith G M BergboerMaša Umićević-MirkovJaap FransenMartin den HeijerBarbara FrankePiet L C M van RielJoost SchalkwijkMarieke J H CoenenNijmegen Biomedical Study principal investigatorsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e32045 (2012) |
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Medicine R Science Q Judith G M Bergboer Maša Umićević-Mirkov Jaap Fransen Martin den Heijer Barbara Franke Piet L C M van Riel Joost Schalkwijk Marieke J H Coenen Nijmegen Biomedical Study principal investigators A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C. |
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<h4>Objective</h4>Two recent studies, in a Spanish and a Chinese population, point to an association between rheumatoid arthritis (RA) risk and the deletion of the Late Cornified Envelope (LCE) 3B and 3C genes (LCE3C_LCE3B-del), a known risk factor for psoriasis. We aimed to replicate these studies in a large Dutch cohort.<h4>Methods</h4>1039 RA cases and 759 controls were genotyped for LCE3C_LCE3B-del. Association analysis was performed for the complete cohort and after stratification for the serologic markers anti-cyclic citrullinated peptide and rheumatoid factor. A meta-analysis was performed combining our data with the Spanish and Chinese datasets, resulting in an analysis including 2466 RA cases and 2438 controls.<h4>Results</h4>In the Dutch cohort we did not observe a significant association of LCE3C_LCE3B-del (p = 0.093) with RA risk. A stratified analysis for the serologic positive and negative group did not show an association between the genetic variant and disease risk, either. The meta-analysis, however, confirmed a significant association (p<0.0001, OR = 1.31, 95% confidence interval 1.16-1.47).<h4>Conclusion</h4>Our meta-analysis confirms the association of the LCE3 deletion with RA, suggesting that LCE3C_LCE3B-del is a common risk factor for (auto)immune diseases. |
| format |
article |
| author |
Judith G M Bergboer Maša Umićević-Mirkov Jaap Fransen Martin den Heijer Barbara Franke Piet L C M van Riel Joost Schalkwijk Marieke J H Coenen Nijmegen Biomedical Study principal investigators |
| author_facet |
Judith G M Bergboer Maša Umićević-Mirkov Jaap Fransen Martin den Heijer Barbara Franke Piet L C M van Riel Joost Schalkwijk Marieke J H Coenen Nijmegen Biomedical Study principal investigators |
| author_sort |
Judith G M Bergboer |
| title |
A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C. |
| title_short |
A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C. |
| title_full |
A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C. |
| title_fullStr |
A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C. |
| title_full_unstemmed |
A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C. |
| title_sort |
replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes lce3b and lce3c. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/a87a4dd435414f628346d0e99f60b8d1 |
| work_keys_str_mv |
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