The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice.

The pituitary gland regulates numerous physiological functions including growth, reproduction, temperature and metabolic homeostasis, lactation, and response to stress. Pituitary organogenesis is dependent on signaling factors that are produced in and around the developing pituitary. The studies des...

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Autores principales:	Jason H Gumbel, Elizabeth M Patterson, Sarah A Owusu, Brock E Kabat, Deborah O Jung, Jasmine Simmons, Torin Hopkins, Buffy S Ellsworth
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a87e55049ddc461ca4d89bed469c7cc1
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spelling	oai:doaj.org-article:a87e55049ddc461ca4d89bed469c7cc12021-11-18T08:04:29ZThe forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice.1932-620310.1371/journal.pone.0052156https://doaj.org/article/a87e55049ddc461ca4d89bed469c7cc12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284914/?tool=EBIhttps://doaj.org/toc/1932-6203The pituitary gland regulates numerous physiological functions including growth, reproduction, temperature and metabolic homeostasis, lactation, and response to stress. Pituitary organogenesis is dependent on signaling factors that are produced in and around the developing pituitary. The studies described in this report reveal that the forkhead transcription factor, Foxd1, is not expressed in the developing mouse pituitary gland, but rather in the mesenchyme surrounding the pituitary gland, which is an essential source of signaling factors that regulate pituitary organogenesis. Loss of Foxd1 causes a morphological defect in which the anterior lobe of the pituitary gland protrudes through the cartilage plate that is developing ventral to the pituitary at embryonic days (e)14.5, e16.5, and e18.5. The number of proliferating pituitary cells is increased at e14.5 and e16.5. Loss of Foxd1 also results in significantly decreased levels of Lhb expression at e18.5. This decrease in Lhb expression does not appear to be due to a change in the number of gonadotrope cells in the pituitary gland. Previous studies have shown that loss of the LIM homeodomain factor, Lhx3, which is activated by the FGF signaling pathway, results in loss of LH production. Although there is a difference in Lhb expression in Foxd1 null mice, the expression pattern of LHX3 is not altered in Foxd1 null mice. These studies suggest that Foxd1 is indirectly required for normal Lhb expression and cartilage formation.Jason H GumbelElizabeth M PattersonSarah A OwusuBrock E KabatDeborah O JungJasmine SimmonsTorin HopkinsBuffy S EllsworthPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52156 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jason H Gumbel Elizabeth M Patterson Sarah A Owusu Brock E Kabat Deborah O Jung Jasmine Simmons Torin Hopkins Buffy S Ellsworth The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice.
description	The pituitary gland regulates numerous physiological functions including growth, reproduction, temperature and metabolic homeostasis, lactation, and response to stress. Pituitary organogenesis is dependent on signaling factors that are produced in and around the developing pituitary. The studies described in this report reveal that the forkhead transcription factor, Foxd1, is not expressed in the developing mouse pituitary gland, but rather in the mesenchyme surrounding the pituitary gland, which is an essential source of signaling factors that regulate pituitary organogenesis. Loss of Foxd1 causes a morphological defect in which the anterior lobe of the pituitary gland protrudes through the cartilage plate that is developing ventral to the pituitary at embryonic days (e)14.5, e16.5, and e18.5. The number of proliferating pituitary cells is increased at e14.5 and e16.5. Loss of Foxd1 also results in significantly decreased levels of Lhb expression at e18.5. This decrease in Lhb expression does not appear to be due to a change in the number of gonadotrope cells in the pituitary gland. Previous studies have shown that loss of the LIM homeodomain factor, Lhx3, which is activated by the FGF signaling pathway, results in loss of LH production. Although there is a difference in Lhb expression in Foxd1 null mice, the expression pattern of LHX3 is not altered in Foxd1 null mice. These studies suggest that Foxd1 is indirectly required for normal Lhb expression and cartilage formation.
format	article
author	Jason H Gumbel Elizabeth M Patterson Sarah A Owusu Brock E Kabat Deborah O Jung Jasmine Simmons Torin Hopkins Buffy S Ellsworth
author_facet	Jason H Gumbel Elizabeth M Patterson Sarah A Owusu Brock E Kabat Deborah O Jung Jasmine Simmons Torin Hopkins Buffy S Ellsworth
author_sort	Jason H Gumbel
title	The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice.
title_short	The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice.
title_full	The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice.
title_fullStr	The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice.
title_full_unstemmed	The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice.
title_sort	forkhead transcription factor, foxd1, is necessary for pituitary luteinizing hormone expression in mice.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a87e55049ddc461ca4d89bed469c7cc1
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The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice.

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