Programmable site-selective labeling of oligonucleotides based on carbene catalysis

The methods for investigation of DNA-binding proteins require site-selective chemical modifications to be introduced into oligonucleotides. Here, the authors report a chemo- and regioselective method for the modification of unpaired guanosines in single- and double-stranded oligonucleotides, based o...

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Autores principales:	Yang-Ha Lee, Eunsoo Yu, Cheol-Min Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a87f440e559c43fb9ceb54897722cfc7
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spelling	oai:doaj.org-article:a87f440e559c43fb9ceb54897722cfc72021-12-02T16:30:43ZProgrammable site-selective labeling of oligonucleotides based on carbene catalysis10.1038/s41467-021-21839-42041-1723https://doaj.org/article/a87f440e559c43fb9ceb54897722cfc72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21839-4https://doaj.org/toc/2041-1723The methods for investigation of DNA-binding proteins require site-selective chemical modifications to be introduced into oligonucleotides. Here, the authors report a chemo- and regioselective method for the modification of unpaired guanosines in single- and double-stranded oligonucleotides, based on Rh(I)-carbene catalysis.Yang-Ha LeeEunsoo YuCheol-Min ParkNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang-Ha Lee Eunsoo Yu Cheol-Min Park Programmable site-selective labeling of oligonucleotides based on carbene catalysis
description	The methods for investigation of DNA-binding proteins require site-selective chemical modifications to be introduced into oligonucleotides. Here, the authors report a chemo- and regioselective method for the modification of unpaired guanosines in single- and double-stranded oligonucleotides, based on Rh(I)-carbene catalysis.
format	article
author	Yang-Ha Lee Eunsoo Yu Cheol-Min Park
author_facet	Yang-Ha Lee Eunsoo Yu Cheol-Min Park
author_sort	Yang-Ha Lee
title	Programmable site-selective labeling of oligonucleotides based on carbene catalysis
title_short	Programmable site-selective labeling of oligonucleotides based on carbene catalysis
title_full	Programmable site-selective labeling of oligonucleotides based on carbene catalysis
title_fullStr	Programmable site-selective labeling of oligonucleotides based on carbene catalysis
title_full_unstemmed	Programmable site-selective labeling of oligonucleotides based on carbene catalysis
title_sort	programmable site-selective labeling of oligonucleotides based on carbene catalysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a87f440e559c43fb9ceb54897722cfc7
work_keys_str_mv	AT yanghalee programmablesiteselectivelabelingofoligonucleotidesbasedoncarbenecatalysis AT eunsooyu programmablesiteselectivelabelingofoligonucleotidesbasedoncarbenecatalysis AT cheolminpark programmablesiteselectivelabelingofoligonucleotidesbasedoncarbenecatalysis
_version_	1718383948415893504

Programmable site-selective labeling of oligonucleotides based on carbene catalysis

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