Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens

Abstract Silver nanoparticles (AgNPs) have been used as a promising alternative to antibiotics in poultry feed. In this study, silver-doped silica nanoparticles (SiO2@AgNPs) were prepared in powder form, using starch, via the chemical reduction method and sol–gel technique followed by full character...

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Autores principales:	Waleed M. Dosoky, Moustafa M. G. Fouda, Ali B. Alwan, Nader R. Abdelsalam, Ayman E. Taha, Rehab Y. Ghareeb, M. R. El-Aassar, Asmaa F. Khafaga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8861ab5e2994c6ebf973db6ba06985c
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spelling	oai:doaj.org-article:a8861ab5e2994c6ebf973db6ba06985c2021-12-02T12:11:52ZDietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens10.1038/s41598-021-83753-52045-2322https://doaj.org/article/a8861ab5e2994c6ebf973db6ba06985c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83753-5https://doaj.org/toc/2045-2322Abstract Silver nanoparticles (AgNPs) have been used as a promising alternative to antibiotics in poultry feed. In this study, silver-doped silica nanoparticles (SiO2@AgNPs) were prepared in powder form, using starch, via the chemical reduction method and sol–gel technique followed by full characterization. SiO2@AgNPs were added to the poultry diet at three doses (2, 4, and 8 mg/kg diet). The safety of the oral dietary supplementation was estimated through the evaluation of the growth performance and hematological, biochemical, and oxidative parameters of birds. Moreover, the immunohistochemical examination of all body organs was also performed. Results of this study showed that SiO2@AgNPs have no negative effects on the growth performance and hematological, biochemical, and oxidative parameters of birds. Moreover, the immunohistochemical examination revealed the minimum inflammatory reactions and lymphoid depletion under a dose level of 8 mg/kg. In conclusion, SiO2@AgNPs could be considered as a promising and safe nano-growth promoter in broilers when added to poultry diet under a dose level of 4 mg/kg diet.Waleed M. DosokyMoustafa M. G. FoudaAli B. AlwanNader R. AbdelsalamAyman E. TahaRehab Y. GhareebM. R. El-AassarAsmaa F. KhafagaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Waleed M. Dosoky Moustafa M. G. Fouda Ali B. Alwan Nader R. Abdelsalam Ayman E. Taha Rehab Y. Ghareeb M. R. El-Aassar Asmaa F. Khafaga Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
description	Abstract Silver nanoparticles (AgNPs) have been used as a promising alternative to antibiotics in poultry feed. In this study, silver-doped silica nanoparticles (SiO2@AgNPs) were prepared in powder form, using starch, via the chemical reduction method and sol–gel technique followed by full characterization. SiO2@AgNPs were added to the poultry diet at three doses (2, 4, and 8 mg/kg diet). The safety of the oral dietary supplementation was estimated through the evaluation of the growth performance and hematological, biochemical, and oxidative parameters of birds. Moreover, the immunohistochemical examination of all body organs was also performed. Results of this study showed that SiO2@AgNPs have no negative effects on the growth performance and hematological, biochemical, and oxidative parameters of birds. Moreover, the immunohistochemical examination revealed the minimum inflammatory reactions and lymphoid depletion under a dose level of 8 mg/kg. In conclusion, SiO2@AgNPs could be considered as a promising and safe nano-growth promoter in broilers when added to poultry diet under a dose level of 4 mg/kg diet.
format	article
author	Waleed M. Dosoky Moustafa M. G. Fouda Ali B. Alwan Nader R. Abdelsalam Ayman E. Taha Rehab Y. Ghareeb M. R. El-Aassar Asmaa F. Khafaga
author_facet	Waleed M. Dosoky Moustafa M. G. Fouda Ali B. Alwan Nader R. Abdelsalam Ayman E. Taha Rehab Y. Ghareeb M. R. El-Aassar Asmaa F. Khafaga
author_sort	Waleed M. Dosoky
title	Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
title_short	Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
title_full	Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
title_fullStr	Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
title_full_unstemmed	Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
title_sort	dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8861ab5e2994c6ebf973db6ba06985c
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Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens

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