Development and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation

Advancements in electrode technologies to both stimulate and record the central nervous system’s electrical activities are enabling significant improvements in both the understanding and treatment of different neurological diseases. However, the current neural recording and stimulating electrodes ar...

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Autores principales:	Bertram Richter, Zachary Mace, Megan E. Hays, Santosh Adhikari, Huy Q. Pham, Robert J. Sclabassi, Benedict Kolber, Saigopalakrishna S. Yerneni, Phil Campbell, Boyle Cheng, Nestor Tomycz, Donald M. Whiting, Trung Q. Le, Toby L. Nelson, Saadyah Averick
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	conductive sensing fiber electrical probe nerve stimulation Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/a88dd28b1fa447ee9c2f0f5f544e6f6f
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spelling	oai:doaj.org-article:a88dd28b1fa447ee9c2f0f5f544e6f6f2021-11-25T18:57:38ZDevelopment and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation10.3390/s212275811424-8220https://doaj.org/article/a88dd28b1fa447ee9c2f0f5f544e6f6f2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8220/21/22/7581https://doaj.org/toc/1424-8220Advancements in electrode technologies to both stimulate and record the central nervous system’s electrical activities are enabling significant improvements in both the understanding and treatment of different neurological diseases. However, the current neural recording and stimulating electrodes are metallic, requiring invasive and damaging methods to interface with neural tissue. These electrodes may also degrade, resulting in additional invasive procedures. Furthermore, metal electrodes may cause nerve damage due to their inherent rigidity. This paper demonstrates that novel electrically conductive organic fibers (ECFs) can be used for direct nerve stimulation. The ECFs were prepared using a standard polyester material as the structural base, with a carbon nanotube ink applied to the surface as the electrical conductor. We report on three experiments: the first one to characterize the conductive properties of the ECFs; the second one to investigate the fiber cytotoxic properties in vitro; and the third one to demonstrate the utility of the ECF for direct nerve stimulation in an in vivo rodent model.Bertram RichterZachary MaceMegan E. HaysSantosh AdhikariHuy Q. PhamRobert J. SclabassiBenedict KolberSaigopalakrishna S. YerneniPhil CampbellBoyle ChengNestor TomyczDonald M. WhitingTrung Q. LeToby L. NelsonSaadyah AverickMDPI AGarticleconductive sensing fiberelectrical probenerve stimulationChemical technologyTP1-1185ENSensors, Vol 21, Iss 7581, p 7581 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	conductive sensing fiber electrical probe nerve stimulation Chemical technology TP1-1185
spellingShingle	conductive sensing fiber electrical probe nerve stimulation Chemical technology TP1-1185 Bertram Richter Zachary Mace Megan E. Hays Santosh Adhikari Huy Q. Pham Robert J. Sclabassi Benedict Kolber Saigopalakrishna S. Yerneni Phil Campbell Boyle Cheng Nestor Tomycz Donald M. Whiting Trung Q. Le Toby L. Nelson Saadyah Averick Development and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation
description	Advancements in electrode technologies to both stimulate and record the central nervous system’s electrical activities are enabling significant improvements in both the understanding and treatment of different neurological diseases. However, the current neural recording and stimulating electrodes are metallic, requiring invasive and damaging methods to interface with neural tissue. These electrodes may also degrade, resulting in additional invasive procedures. Furthermore, metal electrodes may cause nerve damage due to their inherent rigidity. This paper demonstrates that novel electrically conductive organic fibers (ECFs) can be used for direct nerve stimulation. The ECFs were prepared using a standard polyester material as the structural base, with a carbon nanotube ink applied to the surface as the electrical conductor. We report on three experiments: the first one to characterize the conductive properties of the ECFs; the second one to investigate the fiber cytotoxic properties in vitro; and the third one to demonstrate the utility of the ECF for direct nerve stimulation in an in vivo rodent model.
format	article
author	Bertram Richter Zachary Mace Megan E. Hays Santosh Adhikari Huy Q. Pham Robert J. Sclabassi Benedict Kolber Saigopalakrishna S. Yerneni Phil Campbell Boyle Cheng Nestor Tomycz Donald M. Whiting Trung Q. Le Toby L. Nelson Saadyah Averick
author_facet	Bertram Richter Zachary Mace Megan E. Hays Santosh Adhikari Huy Q. Pham Robert J. Sclabassi Benedict Kolber Saigopalakrishna S. Yerneni Phil Campbell Boyle Cheng Nestor Tomycz Donald M. Whiting Trung Q. Le Toby L. Nelson Saadyah Averick
author_sort	Bertram Richter
title	Development and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation
title_short	Development and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation
title_full	Development and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation
title_fullStr	Development and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation
title_full_unstemmed	Development and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation
title_sort	development and characterization of novel conductive sensing fibers for in vivo nerve stimulation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a88dd28b1fa447ee9c2f0f5f544e6f6f
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_version_	1718410480713728000

Development and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation

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