Cortical silent period reflects individual differences in action stopping performance

Abstract Inhibitory control is the ability to suppress inappropriate movements and unwanted actions, allowing to regulate impulses and responses. This ability can be measured via the Stop Signal Task, which provides a temporal index of response inhibition, namely the stop signal reaction time (SSRT...

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Autores principales:	Mario Paci, Giulio Di Cosmo, Mauro Gianni Perrucci, Francesca Ferri, Marcello Costantini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a88fdc52510d4ee798bc1cfd2000c779
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spelling	oai:doaj.org-article:a88fdc52510d4ee798bc1cfd2000c7792021-12-02T18:47:03ZCortical silent period reflects individual differences in action stopping performance10.1038/s41598-021-94494-w2045-2322https://doaj.org/article/a88fdc52510d4ee798bc1cfd2000c7792021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94494-whttps://doaj.org/toc/2045-2322Abstract Inhibitory control is the ability to suppress inappropriate movements and unwanted actions, allowing to regulate impulses and responses. This ability can be measured via the Stop Signal Task, which provides a temporal index of response inhibition, namely the stop signal reaction time (SSRT). At the neural level, Transcranial Magnetic Stimulation (TMS) allows to investigate motor inhibition within the primary motor cortex (M1), such as the cortical silent period (CSP) which is an index of GABAB-mediated intracortical inhibition within M1. Although there is strong evidence that intracortical inhibition varies during action stopping, it is still not clear whether differences in the neurophysiological markers of intracortical inhibition contribute to behavioral differences in actual inhibitory capacities. Hence, here we explored the relationship between intracortical inhibition within M1 and behavioral response inhibition. GABABergic-mediated inhibition in M1 was determined by the duration of CSP, while behavioral inhibition was assessed by the SSRT. We found a significant positive correlation between CSP’s duration and SSRT, namely that individuals with greater levels of GABABergic-mediated inhibition seem to perform overall worse in inhibiting behavioral responses. These results support the assumption that individual differences in intracortical inhibition are mirrored by individual differences in action stopping abilities.Mario PaciGiulio Di CosmoMauro Gianni PerrucciFrancesca FerriMarcello CostantiniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mario Paci Giulio Di Cosmo Mauro Gianni Perrucci Francesca Ferri Marcello Costantini Cortical silent period reflects individual differences in action stopping performance
description	Abstract Inhibitory control is the ability to suppress inappropriate movements and unwanted actions, allowing to regulate impulses and responses. This ability can be measured via the Stop Signal Task, which provides a temporal index of response inhibition, namely the stop signal reaction time (SSRT). At the neural level, Transcranial Magnetic Stimulation (TMS) allows to investigate motor inhibition within the primary motor cortex (M1), such as the cortical silent period (CSP) which is an index of GABAB-mediated intracortical inhibition within M1. Although there is strong evidence that intracortical inhibition varies during action stopping, it is still not clear whether differences in the neurophysiological markers of intracortical inhibition contribute to behavioral differences in actual inhibitory capacities. Hence, here we explored the relationship between intracortical inhibition within M1 and behavioral response inhibition. GABABergic-mediated inhibition in M1 was determined by the duration of CSP, while behavioral inhibition was assessed by the SSRT. We found a significant positive correlation between CSP’s duration and SSRT, namely that individuals with greater levels of GABABergic-mediated inhibition seem to perform overall worse in inhibiting behavioral responses. These results support the assumption that individual differences in intracortical inhibition are mirrored by individual differences in action stopping abilities.
format	article
author	Mario Paci Giulio Di Cosmo Mauro Gianni Perrucci Francesca Ferri Marcello Costantini
author_facet	Mario Paci Giulio Di Cosmo Mauro Gianni Perrucci Francesca Ferri Marcello Costantini
author_sort	Mario Paci
title	Cortical silent period reflects individual differences in action stopping performance
title_short	Cortical silent period reflects individual differences in action stopping performance
title_full	Cortical silent period reflects individual differences in action stopping performance
title_fullStr	Cortical silent period reflects individual differences in action stopping performance
title_full_unstemmed	Cortical silent period reflects individual differences in action stopping performance
title_sort	cortical silent period reflects individual differences in action stopping performance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a88fdc52510d4ee798bc1cfd2000c779
work_keys_str_mv	AT mariopaci corticalsilentperiodreflectsindividualdifferencesinactionstoppingperformance AT giuliodicosmo corticalsilentperiodreflectsindividualdifferencesinactionstoppingperformance AT maurogianniperrucci corticalsilentperiodreflectsindividualdifferencesinactionstoppingperformance AT francescaferri corticalsilentperiodreflectsindividualdifferencesinactionstoppingperformance AT marcellocostantini corticalsilentperiodreflectsindividualdifferencesinactionstoppingperformance
_version_	1718377697463238656

Cortical silent period reflects individual differences in action stopping performance

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