A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary hypertension and a subset of human cancer cells.

Guardado en:
Detalles Bibliográficos
Autores principales: Swati Dabral, Christian Muecke, Chanil Valasarajan, Mario Schmoranzer, Astrid Wietelmann, Gregg L. Semenza, Michael Meister, Thomas Muley, Tamina Seeger-Nukpezah, Christos Samakovlis, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Rajkumar Savai, Soni S. Pullamsetti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/a8901cfbf7474186b10f84b921b3e98d
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a8901cfbf7474186b10f84b921b3e98d
record_format dspace
spelling oai:doaj.org-article:a8901cfbf7474186b10f84b921b3e98d2021-12-02T16:58:25ZA RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension10.1038/s41467-019-10044-z2041-1723https://doaj.org/article/a8901cfbf7474186b10f84b921b3e98d2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10044-zhttps://doaj.org/toc/2041-1723Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary hypertension and a subset of human cancer cells.Swati DabralChristian MueckeChanil ValasarajanMario SchmoranzerAstrid WietelmannGregg L. SemenzaMichael MeisterThomas MuleyTamina Seeger-NukpezahChristos SamakovlisNorbert WeissmannFriedrich GrimmingerWerner SeegerRajkumar SavaiSoni S. PullamsettiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Swati Dabral
Christian Muecke
Chanil Valasarajan
Mario Schmoranzer
Astrid Wietelmann
Gregg L. Semenza
Michael Meister
Thomas Muley
Tamina Seeger-Nukpezah
Christos Samakovlis
Norbert Weissmann
Friedrich Grimminger
Werner Seeger
Rajkumar Savai
Soni S. Pullamsetti
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
description Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary hypertension and a subset of human cancer cells.
format article
author Swati Dabral
Christian Muecke
Chanil Valasarajan
Mario Schmoranzer
Astrid Wietelmann
Gregg L. Semenza
Michael Meister
Thomas Muley
Tamina Seeger-Nukpezah
Christos Samakovlis
Norbert Weissmann
Friedrich Grimminger
Werner Seeger
Rajkumar Savai
Soni S. Pullamsetti
author_facet Swati Dabral
Christian Muecke
Chanil Valasarajan
Mario Schmoranzer
Astrid Wietelmann
Gregg L. Semenza
Michael Meister
Thomas Muley
Tamina Seeger-Nukpezah
Christos Samakovlis
Norbert Weissmann
Friedrich Grimminger
Werner Seeger
Rajkumar Savai
Soni S. Pullamsetti
author_sort Swati Dabral
title A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
title_short A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
title_full A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
title_fullStr A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
title_full_unstemmed A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
title_sort rassf1a-hif1α loop drives warburg effect in cancer and pulmonary hypertension
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/a8901cfbf7474186b10f84b921b3e98d
work_keys_str_mv AT swatidabral arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT christianmuecke arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT chanilvalasarajan arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT marioschmoranzer arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT astridwietelmann arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT gregglsemenza arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT michaelmeister arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT thomasmuley arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT taminaseegernukpezah arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT christossamakovlis arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT norbertweissmann arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT friedrichgrimminger arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT wernerseeger arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT rajkumarsavai arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT sonispullamsetti arassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT swatidabral rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT christianmuecke rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT chanilvalasarajan rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT marioschmoranzer rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT astridwietelmann rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT gregglsemenza rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT michaelmeister rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT thomasmuley rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT taminaseegernukpezah rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT christossamakovlis rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT norbertweissmann rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT friedrichgrimminger rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT wernerseeger rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT rajkumarsavai rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
AT sonispullamsetti rassf1ahif1aloopdriveswarburgeffectincancerandpulmonaryhypertension
_version_ 1718382347892555776

Ejemplares similares