Use of Amniotic Membrane in MMC-Augmented Trabeculectomy: A Retrospective Comparative Study

Joana Roque,1 Fernando Trancoso Vaz,1 Rita Basto,1 Susana Henriques,1 Ana Sofia Lopes,1 Diana Silva,1 Jorge Santos,2 Graça Pires,1 Maria Lisboa,1 Isabel Prieto1 1Ophthalmology Department, Prof. Doutor Fernando Fonseca Hospital, Amadora, Lisbon, Portugal; 2Department of Mathematics ECT, CIMA IIFA Évo...

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Autores principales:	Roque J, Vaz FT, Basto R, Henriques S, Lopes AS, Silva D, Santos J, Pires G, Lisboa M, Prieto I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	trabeculectomy glaucoma mitomycin c amniotic membrane antifibrotics scarring Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a893efe8b1c44257923cf5989a00fb88
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spelling	oai:doaj.org-article:a893efe8b1c44257923cf5989a00fb882021-11-28T19:13:10ZUse of Amniotic Membrane in MMC-Augmented Trabeculectomy: A Retrospective Comparative Study1177-5483https://doaj.org/article/a893efe8b1c44257923cf5989a00fb882021-11-01T00:00:00Zhttps://www.dovepress.com/use-of-amniotic-membrane-in-mmc-augmented-trabeculectomy-a-retrospecti-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Joana Roque,1 Fernando Trancoso Vaz,1 Rita Basto,1 Susana Henriques,1 Ana Sofia Lopes,1 Diana Silva,1 Jorge Santos,2 Graça Pires,1 Maria Lisboa,1 Isabel Prieto1 1Ophthalmology Department, Prof. Doutor Fernando Fonseca Hospital, Amadora, Lisbon, Portugal; 2Department of Mathematics ECT, CIMA IIFA Évora University, Évora, PortugalCorrespondence: Joana RoqueOphthalmology Department, Prof. Doutor Fernando Fonseca Hospital, Amadora, Lisbon, IC19 2720-276, PortugalTel +351932828099Email joana.roque@hff.min-saude.ptPurpose: Amniotic membrane transplantation (AMT) has shown promising results as an antifibrotic agent in trabeculectomy. We aimed to evaluate the additional effect of AMT in MMC-augmented trabeculectomy.Patients and Methods: This retrospective study analyzed the results of the first 12 postoperative months of glaucomatous eyes submitted to Moorfields Safer Surgery Trabeculectomy with MMC alone (non-AMT group) compared to MMC and AMT (AMT group). Both groups were compared in terms of intraocular pressure (IOP), number of antihypertensive medications and need for surgical reinterventions. Absolute and relative success rates 12 months after surgery were defined as IOP < 18 mmHg, without and with the use of antihypertensive medications, respectively.Results: The analysis included 51 eyes of 45 glaucoma patients (29 eyes in the non-AMT group and 22 in the AMT group). Mean IOP decreased from 24.72± 5.11 mmHg and 26.86± 10.62 mmHg preoperatively in non-AMT and AMT groups to 12.86± 4.22 mmHg and 12.60± 4.43 mmHg, respectively, at 12 months (p = 0.84). Postoperative number of medications decreased significantly in both groups. Absolute success was seen in 71% of non-AMT eyes and 55% of AMT eyes (p = 0.46), whereas relative success was obtained in 14% and 30%, respectively (p = 0.55). Reinterventions were needed in 28% of the eyes (11 bleb injection/needling and 4 Ahmed tube implantation) in the non-AMT group and in 27% of the AMT group (10 bleb injection/needling and 1 Ahmed tube implantation) (p = 0.89).Conclusion: Trabeculectomy combined with MMC and AMT did not show better results than trabeculectomy with MMC alone.Keywords: trabeculectomy, glaucoma, mitomycin C, amniotic membrane, antifibrotics, scarringRoque JVaz FTBasto RHenriques SLopes ASSilva DSantos JPires GLisboa MPrieto IDove Medical Pressarticletrabeculectomyglaucomamitomycin camniotic membraneantifibroticsscarringOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 4527-4533 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	trabeculectomy glaucoma mitomycin c amniotic membrane antifibrotics scarring Ophthalmology RE1-994
spellingShingle	trabeculectomy glaucoma mitomycin c amniotic membrane antifibrotics scarring Ophthalmology RE1-994 Roque J Vaz FT Basto R Henriques S Lopes AS Silva D Santos J Pires G Lisboa M Prieto I Use of Amniotic Membrane in MMC-Augmented Trabeculectomy: A Retrospective Comparative Study
description	Joana Roque,1 Fernando Trancoso Vaz,1 Rita Basto,1 Susana Henriques,1 Ana Sofia Lopes,1 Diana Silva,1 Jorge Santos,2 Graça Pires,1 Maria Lisboa,1 Isabel Prieto1 1Ophthalmology Department, Prof. Doutor Fernando Fonseca Hospital, Amadora, Lisbon, Portugal; 2Department of Mathematics ECT, CIMA IIFA Évora University, Évora, PortugalCorrespondence: Joana RoqueOphthalmology Department, Prof. Doutor Fernando Fonseca Hospital, Amadora, Lisbon, IC19 2720-276, PortugalTel +351932828099Email joana.roque@hff.min-saude.ptPurpose: Amniotic membrane transplantation (AMT) has shown promising results as an antifibrotic agent in trabeculectomy. We aimed to evaluate the additional effect of AMT in MMC-augmented trabeculectomy.Patients and Methods: This retrospective study analyzed the results of the first 12 postoperative months of glaucomatous eyes submitted to Moorfields Safer Surgery Trabeculectomy with MMC alone (non-AMT group) compared to MMC and AMT (AMT group). Both groups were compared in terms of intraocular pressure (IOP), number of antihypertensive medications and need for surgical reinterventions. Absolute and relative success rates 12 months after surgery were defined as IOP < 18 mmHg, without and with the use of antihypertensive medications, respectively.Results: The analysis included 51 eyes of 45 glaucoma patients (29 eyes in the non-AMT group and 22 in the AMT group). Mean IOP decreased from 24.72± 5.11 mmHg and 26.86± 10.62 mmHg preoperatively in non-AMT and AMT groups to 12.86± 4.22 mmHg and 12.60± 4.43 mmHg, respectively, at 12 months (p = 0.84). Postoperative number of medications decreased significantly in both groups. Absolute success was seen in 71% of non-AMT eyes and 55% of AMT eyes (p = 0.46), whereas relative success was obtained in 14% and 30%, respectively (p = 0.55). Reinterventions were needed in 28% of the eyes (11 bleb injection/needling and 4 Ahmed tube implantation) in the non-AMT group and in 27% of the AMT group (10 bleb injection/needling and 1 Ahmed tube implantation) (p = 0.89).Conclusion: Trabeculectomy combined with MMC and AMT did not show better results than trabeculectomy with MMC alone.Keywords: trabeculectomy, glaucoma, mitomycin C, amniotic membrane, antifibrotics, scarring
format	article
author	Roque J Vaz FT Basto R Henriques S Lopes AS Silva D Santos J Pires G Lisboa M Prieto I
author_facet	Roque J Vaz FT Basto R Henriques S Lopes AS Silva D Santos J Pires G Lisboa M Prieto I
author_sort	Roque J
title	Use of Amniotic Membrane in MMC-Augmented Trabeculectomy: A Retrospective Comparative Study
title_short	Use of Amniotic Membrane in MMC-Augmented Trabeculectomy: A Retrospective Comparative Study
title_full	Use of Amniotic Membrane in MMC-Augmented Trabeculectomy: A Retrospective Comparative Study
title_fullStr	Use of Amniotic Membrane in MMC-Augmented Trabeculectomy: A Retrospective Comparative Study
title_full_unstemmed	Use of Amniotic Membrane in MMC-Augmented Trabeculectomy: A Retrospective Comparative Study
title_sort	use of amniotic membrane in mmc-augmented trabeculectomy: a retrospective comparative study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a893efe8b1c44257923cf5989a00fb88
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Use of Amniotic Membrane in MMC-Augmented Trabeculectomy: A Retrospective Comparative Study

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