Inference and interrogation of a coregulatory network in the context of lipid accumulation in Yarrowia lipolytica

System biology: gene regulatory network for lipid production Bioinformatics allow us to get new insight in yeast gene regulation for the biological production of lipid-derived industrial compounds. This work, led by Jean-Marc Nicaud and Mohamed Elati from the INRA and University of Evry, aimed to id...

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Autores principales:	Pauline Trébulle, Jean-Marc Nicaud, Christophe Leplat, Mohamed Elati
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a89660880fe74a14a984684fd5bd406e
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spelling	oai:doaj.org-article:a89660880fe74a14a984684fd5bd406e2021-12-02T12:33:54ZInference and interrogation of a coregulatory network in the context of lipid accumulation in Yarrowia lipolytica10.1038/s41540-017-0024-12056-7189https://doaj.org/article/a89660880fe74a14a984684fd5bd406e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41540-017-0024-1https://doaj.org/toc/2056-7189System biology: gene regulatory network for lipid production Bioinformatics allow us to get new insight in yeast gene regulation for the biological production of lipid-derived industrial compounds. This work, led by Jean-Marc Nicaud and Mohamed Elati from the INRA and University of Evry, aimed to identify the gene regulatory network and new regulatory elements associated with lipid production in Yarrowia lipolytica, a yeast of industrial interest. Using context-specific gene expression data and a data mining approach, the team was able to build a model of gene regulation from which they identified the main regulators as well as the cooperative relationships between them. These predictions were then confirmed experimentally. Additionally, the team managed to determine different stages of lipid production using a new measure of regulator activity: the influence. These tools will be useful to model and design industrial yeast for various applications.Pauline TrébulleJean-Marc NicaudChristophe LeplatMohamed ElatiNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Pauline Trébulle Jean-Marc Nicaud Christophe Leplat Mohamed Elati Inference and interrogation of a coregulatory network in the context of lipid accumulation in Yarrowia lipolytica
description	System biology: gene regulatory network for lipid production Bioinformatics allow us to get new insight in yeast gene regulation for the biological production of lipid-derived industrial compounds. This work, led by Jean-Marc Nicaud and Mohamed Elati from the INRA and University of Evry, aimed to identify the gene regulatory network and new regulatory elements associated with lipid production in Yarrowia lipolytica, a yeast of industrial interest. Using context-specific gene expression data and a data mining approach, the team was able to build a model of gene regulation from which they identified the main regulators as well as the cooperative relationships between them. These predictions were then confirmed experimentally. Additionally, the team managed to determine different stages of lipid production using a new measure of regulator activity: the influence. These tools will be useful to model and design industrial yeast for various applications.
format	article
author	Pauline Trébulle Jean-Marc Nicaud Christophe Leplat Mohamed Elati
author_facet	Pauline Trébulle Jean-Marc Nicaud Christophe Leplat Mohamed Elati
author_sort	Pauline Trébulle
title	Inference and interrogation of a coregulatory network in the context of lipid accumulation in Yarrowia lipolytica
title_short	Inference and interrogation of a coregulatory network in the context of lipid accumulation in Yarrowia lipolytica
title_full	Inference and interrogation of a coregulatory network in the context of lipid accumulation in Yarrowia lipolytica
title_fullStr	Inference and interrogation of a coregulatory network in the context of lipid accumulation in Yarrowia lipolytica
title_full_unstemmed	Inference and interrogation of a coregulatory network in the context of lipid accumulation in Yarrowia lipolytica
title_sort	inference and interrogation of a coregulatory network in the context of lipid accumulation in yarrowia lipolytica
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a89660880fe74a14a984684fd5bd406e
work_keys_str_mv	AT paulinetrebulle inferenceandinterrogationofacoregulatorynetworkinthecontextoflipidaccumulationinyarrowialipolytica AT jeanmarcnicaud inferenceandinterrogationofacoregulatorynetworkinthecontextoflipidaccumulationinyarrowialipolytica AT christopheleplat inferenceandinterrogationofacoregulatorynetworkinthecontextoflipidaccumulationinyarrowialipolytica AT mohamedelati inferenceandinterrogationofacoregulatorynetworkinthecontextoflipidaccumulationinyarrowialipolytica
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Inference and interrogation of a coregulatory network in the context of lipid accumulation in Yarrowia lipolytica

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