Visual outcomes of lens subluxation surgery with Cionni modified capsular tension rings in Marfan syndrome

Abstract Marfan syndrome (MFS) is a hereditary disease with an incidence of 0.3% in the general population. Approximately 60% of MFS patients with FBN1 gene mutation will suffer ectopia lentis (EL) from the age of 3. With the development of EL, severe loss of vision will accrue because of lens tilt...

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Autores principales:	Tianhui Chen, Michael Deng, Min Zhang, Jiahui Chen, Zexu Chen, Yongxiang Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a89e528e80a74df1bf1e4dc27d23446d
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spelling	oai:doaj.org-article:a89e528e80a74df1bf1e4dc27d23446d2021-12-02T14:06:24ZVisual outcomes of lens subluxation surgery with Cionni modified capsular tension rings in Marfan syndrome10.1038/s41598-021-82586-62045-2322https://doaj.org/article/a89e528e80a74df1bf1e4dc27d23446d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82586-6https://doaj.org/toc/2045-2322Abstract Marfan syndrome (MFS) is a hereditary disease with an incidence of 0.3% in the general population. Approximately 60% of MFS patients with FBN1 gene mutation will suffer ectopia lentis (EL) from the age of 3. With the development of EL, severe loss of vision will accrue because of lens tilt and glaucoma. Cionni modified capsular tension rings (MCTR) has been applied in the surgery for EL in MFS patients. To evaluate visual acuity and safety of using MCTR during lens subluxation surgery in MFS patients, 66 MFS patients (110 eyes) were included in our study, with the mean duration of follow-up of 4.7 months (SD 1.76 months). The capsular bags were preserved in 101 eyes (91.81%) with MCTR implantation. There was an overall significant improvement in BCVA at 1-month follow-up which was maintained at 3 months. Multivariable linear regression revealed that older age at first visit was associated with greater postoperative BCVA at the 1-month follow-up (P = 0.007). A significant difference was found between different degrees of lens subluxation and the length of surgical time and complications. At follow-up, only two eyes (1.98%) were identified to have developed retinal detachments. In conclusion, better visual outcomes can be achieved when patients received an early operation with MCTR implantation.Tianhui ChenMichael DengMin ZhangJiahui ChenZexu ChenYongxiang JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tianhui Chen Michael Deng Min Zhang Jiahui Chen Zexu Chen Yongxiang Jiang Visual outcomes of lens subluxation surgery with Cionni modified capsular tension rings in Marfan syndrome
description	Abstract Marfan syndrome (MFS) is a hereditary disease with an incidence of 0.3% in the general population. Approximately 60% of MFS patients with FBN1 gene mutation will suffer ectopia lentis (EL) from the age of 3. With the development of EL, severe loss of vision will accrue because of lens tilt and glaucoma. Cionni modified capsular tension rings (MCTR) has been applied in the surgery for EL in MFS patients. To evaluate visual acuity and safety of using MCTR during lens subluxation surgery in MFS patients, 66 MFS patients (110 eyes) were included in our study, with the mean duration of follow-up of 4.7 months (SD 1.76 months). The capsular bags were preserved in 101 eyes (91.81%) with MCTR implantation. There was an overall significant improvement in BCVA at 1-month follow-up which was maintained at 3 months. Multivariable linear regression revealed that older age at first visit was associated with greater postoperative BCVA at the 1-month follow-up (P = 0.007). A significant difference was found between different degrees of lens subluxation and the length of surgical time and complications. At follow-up, only two eyes (1.98%) were identified to have developed retinal detachments. In conclusion, better visual outcomes can be achieved when patients received an early operation with MCTR implantation.
format	article
author	Tianhui Chen Michael Deng Min Zhang Jiahui Chen Zexu Chen Yongxiang Jiang
author_facet	Tianhui Chen Michael Deng Min Zhang Jiahui Chen Zexu Chen Yongxiang Jiang
author_sort	Tianhui Chen
title	Visual outcomes of lens subluxation surgery with Cionni modified capsular tension rings in Marfan syndrome
title_short	Visual outcomes of lens subluxation surgery with Cionni modified capsular tension rings in Marfan syndrome
title_full	Visual outcomes of lens subluxation surgery with Cionni modified capsular tension rings in Marfan syndrome
title_fullStr	Visual outcomes of lens subluxation surgery with Cionni modified capsular tension rings in Marfan syndrome
title_full_unstemmed	Visual outcomes of lens subluxation surgery with Cionni modified capsular tension rings in Marfan syndrome
title_sort	visual outcomes of lens subluxation surgery with cionni modified capsular tension rings in marfan syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a89e528e80a74df1bf1e4dc27d23446d
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Visual outcomes of lens subluxation surgery with Cionni modified capsular tension rings in Marfan syndrome

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