Calorimetric analysis of ice onset temperature during cryoablation: a model approach to identify early predictors of effective applications

Abstract Aim of the present study is to analyze thermal events occurring during cryoablation. Different bovine liver samples underwent freezing cycles at different cooling rate (from 0.0075 to 25 K/min). Ice onset temperature and specific latent heat capacity of the ice formation process were measur...

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Autores principales:	Elena Campagnoli, Andrea Ballatore, Valter Giaretto, Matteo Anselmino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8a34d30954645ceace53e3ff1ffe4f6
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spelling	oai:doaj.org-article:a8a34d30954645ceace53e3ff1ffe4f62021-12-02T18:49:21ZCalorimetric analysis of ice onset temperature during cryoablation: a model approach to identify early predictors of effective applications10.1038/s41598-021-95204-22045-2322https://doaj.org/article/a8a34d30954645ceace53e3ff1ffe4f62021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95204-2https://doaj.org/toc/2045-2322Abstract Aim of the present study is to analyze thermal events occurring during cryoablation. Different bovine liver samples underwent freezing cycles at different cooling rate (from 0.0075 to 25 K/min). Ice onset temperature and specific latent heat capacity of the ice formation process were measured according to differential scanning calorimetry signals. A computational model of the thermal events occurring during cryoablation was compiled using Neumann’s analytical solution. Latent heat (#1 = 139.8 ± 7.4 J/g, #2 = 147.8 ± 7.9 J/g, #3 = 159.0 ± 4.1 J/g) of all liver samples was independent of the ice onset temperature, but linearly dependent on the water content. Ice onset temperature was proportional to the logarithm of the cooling rate in the range 5 ÷ 25 K/min (#3a = − 12.2 °C, #3b = − 16.2 °C, #3c = − 6.6 °C at 5K/min; #3a = − 16.5 °C, #3b = − 19.3 °C, #3c = − 11.6 °C at 25 K/min). Ice onset temperature was associated with both the way in which the heat involved into the phase transition was delivered and with the thermal gradient inside the tissue. Ice onset temperature should be evaluated in the early phase of the ablation to tailor cryoenergy delivery. In order to obtain low ice trigger temperatures and consequent low ablation temperatures a high cooling rate is necessary.Elena CampagnoliAndrea BallatoreValter GiarettoMatteo AnselminoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elena Campagnoli Andrea Ballatore Valter Giaretto Matteo Anselmino Calorimetric analysis of ice onset temperature during cryoablation: a model approach to identify early predictors of effective applications
description	Abstract Aim of the present study is to analyze thermal events occurring during cryoablation. Different bovine liver samples underwent freezing cycles at different cooling rate (from 0.0075 to 25 K/min). Ice onset temperature and specific latent heat capacity of the ice formation process were measured according to differential scanning calorimetry signals. A computational model of the thermal events occurring during cryoablation was compiled using Neumann’s analytical solution. Latent heat (#1 = 139.8 ± 7.4 J/g, #2 = 147.8 ± 7.9 J/g, #3 = 159.0 ± 4.1 J/g) of all liver samples was independent of the ice onset temperature, but linearly dependent on the water content. Ice onset temperature was proportional to the logarithm of the cooling rate in the range 5 ÷ 25 K/min (#3a = − 12.2 °C, #3b = − 16.2 °C, #3c = − 6.6 °C at 5K/min; #3a = − 16.5 °C, #3b = − 19.3 °C, #3c = − 11.6 °C at 25 K/min). Ice onset temperature was associated with both the way in which the heat involved into the phase transition was delivered and with the thermal gradient inside the tissue. Ice onset temperature should be evaluated in the early phase of the ablation to tailor cryoenergy delivery. In order to obtain low ice trigger temperatures and consequent low ablation temperatures a high cooling rate is necessary.
format	article
author	Elena Campagnoli Andrea Ballatore Valter Giaretto Matteo Anselmino
author_facet	Elena Campagnoli Andrea Ballatore Valter Giaretto Matteo Anselmino
author_sort	Elena Campagnoli
title	Calorimetric analysis of ice onset temperature during cryoablation: a model approach to identify early predictors of effective applications
title_short	Calorimetric analysis of ice onset temperature during cryoablation: a model approach to identify early predictors of effective applications
title_full	Calorimetric analysis of ice onset temperature during cryoablation: a model approach to identify early predictors of effective applications
title_fullStr	Calorimetric analysis of ice onset temperature during cryoablation: a model approach to identify early predictors of effective applications
title_full_unstemmed	Calorimetric analysis of ice onset temperature during cryoablation: a model approach to identify early predictors of effective applications
title_sort	calorimetric analysis of ice onset temperature during cryoablation: a model approach to identify early predictors of effective applications
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8a34d30954645ceace53e3ff1ffe4f6
work_keys_str_mv	AT elenacampagnoli calorimetricanalysisoficeonsettemperatureduringcryoablationamodelapproachtoidentifyearlypredictorsofeffectiveapplications AT andreaballatore calorimetricanalysisoficeonsettemperatureduringcryoablationamodelapproachtoidentifyearlypredictorsofeffectiveapplications AT valtergiaretto calorimetricanalysisoficeonsettemperatureduringcryoablationamodelapproachtoidentifyearlypredictorsofeffectiveapplications AT matteoanselmino calorimetricanalysisoficeonsettemperatureduringcryoablationamodelapproachtoidentifyearlypredictorsofeffectiveapplications
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Calorimetric analysis of ice onset temperature during cryoablation: a model approach to identify early predictors of effective applications

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