Elevated baseline potassium level within reference range is associated with worse clinical outcomes in hospitalised patients

Abstract The clinical significance of elevated baseline serum potassium (K+) levels in hospitalised patients is rarely described. Hence, we performed a retrospective study assessing the significance of elevated K+ levels in a one-year admission cohort. Adult patients without hypokalaemia or end-stag...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sehoon Park, Seon Ha Baek, Sung Woo Lee, Anna Lee, Ho Jun Chin, Ki Young Na, Yon Su Kim, Dong-Wan Chae, Jin Suk Han, Sejoong Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8a40ed528da4dc197b3c06a4232eac6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a8a40ed528da4dc197b3c06a4232eac6
record_format	dspace
spelling	oai:doaj.org-article:a8a40ed528da4dc197b3c06a4232eac62021-12-02T12:32:41ZElevated baseline potassium level within reference range is associated with worse clinical outcomes in hospitalised patients10.1038/s41598-017-02681-52045-2322https://doaj.org/article/a8a40ed528da4dc197b3c06a4232eac62017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02681-5https://doaj.org/toc/2045-2322Abstract The clinical significance of elevated baseline serum potassium (K+) levels in hospitalised patients is rarely described. Hence, we performed a retrospective study assessing the significance of elevated K+ levels in a one-year admission cohort. Adult patients without hypokalaemia or end-stage renal disease were included. Adverse outcomes were all-cause mortality, hospital-acquired acute kidney injury, and events of arrhythmia. In total, 17,777 patients were included in the study cohort, and a significant difference (P < 0.001) was observed in mortality according to baseline serum K+ levels. The adjusted hazard ratios (HRs) and associated 95% confidence intervals (CIs) of all-cause mortality for K+ levels above the reference range of 3.6–4.0 mmol/L were as follows: 4.1–4.5 mmol/L, adjusted HR 1.075 (95% CI 0.981–1.180); 4.6–5.0 mmol/L, adjusted HR 1.261 (1.105–1.439); 5.1–5.5 mmol/L, adjusted HR 1.310 (1.009–1.700); >5.5 mmol/L, adjusted HR 2.119 (1.532–2.930). Moreover, the risks of in-hospital acute kidney injury and arrhythmia were higher in patients with serum K+ levels above 4.0 mmol/L and 5.5 mmol/L, respectively. In conclusion, increased serum K+ levels, including mild elevations may be related to worse prognosis. Close monitoring and prompt correction of underlying causes or hyperkalaemia itself is warranted for admitted patients.Sehoon ParkSeon Ha BaekSung Woo LeeAnna LeeHo Jun ChinKi Young NaYon Su KimDong-Wan ChaeJin Suk HanSejoong KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sehoon Park Seon Ha Baek Sung Woo Lee Anna Lee Ho Jun Chin Ki Young Na Yon Su Kim Dong-Wan Chae Jin Suk Han Sejoong Kim Elevated baseline potassium level within reference range is associated with worse clinical outcomes in hospitalised patients
description	Abstract The clinical significance of elevated baseline serum potassium (K+) levels in hospitalised patients is rarely described. Hence, we performed a retrospective study assessing the significance of elevated K+ levels in a one-year admission cohort. Adult patients without hypokalaemia or end-stage renal disease were included. Adverse outcomes were all-cause mortality, hospital-acquired acute kidney injury, and events of arrhythmia. In total, 17,777 patients were included in the study cohort, and a significant difference (P < 0.001) was observed in mortality according to baseline serum K+ levels. The adjusted hazard ratios (HRs) and associated 95% confidence intervals (CIs) of all-cause mortality for K+ levels above the reference range of 3.6–4.0 mmol/L were as follows: 4.1–4.5 mmol/L, adjusted HR 1.075 (95% CI 0.981–1.180); 4.6–5.0 mmol/L, adjusted HR 1.261 (1.105–1.439); 5.1–5.5 mmol/L, adjusted HR 1.310 (1.009–1.700); >5.5 mmol/L, adjusted HR 2.119 (1.532–2.930). Moreover, the risks of in-hospital acute kidney injury and arrhythmia were higher in patients with serum K+ levels above 4.0 mmol/L and 5.5 mmol/L, respectively. In conclusion, increased serum K+ levels, including mild elevations may be related to worse prognosis. Close monitoring and prompt correction of underlying causes or hyperkalaemia itself is warranted for admitted patients.
format	article
author	Sehoon Park Seon Ha Baek Sung Woo Lee Anna Lee Ho Jun Chin Ki Young Na Yon Su Kim Dong-Wan Chae Jin Suk Han Sejoong Kim
author_facet	Sehoon Park Seon Ha Baek Sung Woo Lee Anna Lee Ho Jun Chin Ki Young Na Yon Su Kim Dong-Wan Chae Jin Suk Han Sejoong Kim
author_sort	Sehoon Park
title	Elevated baseline potassium level within reference range is associated with worse clinical outcomes in hospitalised patients
title_short	Elevated baseline potassium level within reference range is associated with worse clinical outcomes in hospitalised patients
title_full	Elevated baseline potassium level within reference range is associated with worse clinical outcomes in hospitalised patients
title_fullStr	Elevated baseline potassium level within reference range is associated with worse clinical outcomes in hospitalised patients
title_full_unstemmed	Elevated baseline potassium level within reference range is associated with worse clinical outcomes in hospitalised patients
title_sort	elevated baseline potassium level within reference range is associated with worse clinical outcomes in hospitalised patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a8a40ed528da4dc197b3c06a4232eac6
work_keys_str_mv	AT sehoonpark elevatedbaselinepotassiumlevelwithinreferencerangeisassociatedwithworseclinicaloutcomesinhospitalisedpatients AT seonhabaek elevatedbaselinepotassiumlevelwithinreferencerangeisassociatedwithworseclinicaloutcomesinhospitalisedpatients AT sungwoolee elevatedbaselinepotassiumlevelwithinreferencerangeisassociatedwithworseclinicaloutcomesinhospitalisedpatients AT annalee elevatedbaselinepotassiumlevelwithinreferencerangeisassociatedwithworseclinicaloutcomesinhospitalisedpatients AT hojunchin elevatedbaselinepotassiumlevelwithinreferencerangeisassociatedwithworseclinicaloutcomesinhospitalisedpatients AT kiyoungna elevatedbaselinepotassiumlevelwithinreferencerangeisassociatedwithworseclinicaloutcomesinhospitalisedpatients AT yonsukim elevatedbaselinepotassiumlevelwithinreferencerangeisassociatedwithworseclinicaloutcomesinhospitalisedpatients AT dongwanchae elevatedbaselinepotassiumlevelwithinreferencerangeisassociatedwithworseclinicaloutcomesinhospitalisedpatients AT jinsukhan elevatedbaselinepotassiumlevelwithinreferencerangeisassociatedwithworseclinicaloutcomesinhospitalisedpatients AT sejoongkim elevatedbaselinepotassiumlevelwithinreferencerangeisassociatedwithworseclinicaloutcomesinhospitalisedpatients
_version_	1718393998277607424

Elevated baseline potassium level within reference range is associated with worse clinical outcomes in hospitalised patients

Ejemplares similares