Adiponectin/adiponectin receptors mRNA expression profiles in chickens and their response to feed restriction

ABSTRACT: Adiponectin (ADPN) is related to fatty acid synthesis and oxidation in mammals. In chickens, the lipid metabolism, structure and sequence of ADPN are different from that in mammals. The aim of this study was to determine the role of ADPN in broilers lipid metabolism by investigating the te...

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Autores principales:	Jiangxue Cai, Qingmei Hu, Hai Lin, Jingpeng Zhao, Hongchao Jiao, Xiaojuan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	broiler lipid metabolism adiponectin fasting Animal culture SF1-1100
Acceso en línea:	https://doaj.org/article/a8a7d9ea13fb4d7ca503ff05910e7a08
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spelling	oai:doaj.org-article:a8a7d9ea13fb4d7ca503ff05910e7a082021-11-24T04:22:05ZAdiponectin/adiponectin receptors mRNA expression profiles in chickens and their response to feed restriction0032-579110.1016/j.psj.2021.101480https://doaj.org/article/a8a7d9ea13fb4d7ca503ff05910e7a082021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0032579121005022https://doaj.org/toc/0032-5791ABSTRACT: Adiponectin (ADPN) is related to fatty acid synthesis and oxidation in mammals. In chickens, the lipid metabolism, structure and sequence of ADPN are different from that in mammals. The aim of this study was to determine the role of ADPN in broilers lipid metabolism by investigating the temporal and spatial expression profiles of ADPN and its receptors, as well as their response to feed restriction. The results showed that the abdominal fat has the highest expression level, followed by the duodenum, glandular stomach, heart, hypothalamus, liver, and skeletal muscle. Broilers have high energy mobilization during their early stage of growth, in which the fat demand in the liver and muscles is high, thus the expression of ADPN and its receptor are also increased. To study the effects of feed restriction on ADPN and lipid metabolism, broilers were fasted for 12 h and refeed for 2 h. The results showed that fasting decreased the concentration of triglyceride (TG) (P < 0.05) and total cholesterol (TCHO) (P < 0.05) in plasma. The mRNA expression of ADPN in the liver (P < 0.05), breast (P < 0.05) and thigh (P < 0.05), and the mRNA expression of ADPNR1 in the liver (P < 0.05) and duodenum (P < 0.05) were significantly increased in the Fasted group. All above phenomena were recovered after refeeding, suggesting that feed restriction may promote the utilization of fatty acids in active metabolism tissues through ADPN, to guarantee the energy homeostasis of the body. However, the AMP-activated protein kinase (AMPK) signaling pathway and hepatic lipid metabolism were not necessary to cause the above changes under this experimental condition.Jiangxue CaiQingmei HuHai LinJingpeng ZhaoHongchao JiaoXiaojuan WangElsevierarticlebroilerlipid metabolismadiponectinfastingAnimal cultureSF1-1100ENPoultry Science, Vol 100, Iss 12, Pp 101480- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	broiler lipid metabolism adiponectin fasting Animal culture SF1-1100
spellingShingle	broiler lipid metabolism adiponectin fasting Animal culture SF1-1100 Jiangxue Cai Qingmei Hu Hai Lin Jingpeng Zhao Hongchao Jiao Xiaojuan Wang Adiponectin/adiponectin receptors mRNA expression profiles in chickens and their response to feed restriction
description	ABSTRACT: Adiponectin (ADPN) is related to fatty acid synthesis and oxidation in mammals. In chickens, the lipid metabolism, structure and sequence of ADPN are different from that in mammals. The aim of this study was to determine the role of ADPN in broilers lipid metabolism by investigating the temporal and spatial expression profiles of ADPN and its receptors, as well as their response to feed restriction. The results showed that the abdominal fat has the highest expression level, followed by the duodenum, glandular stomach, heart, hypothalamus, liver, and skeletal muscle. Broilers have high energy mobilization during their early stage of growth, in which the fat demand in the liver and muscles is high, thus the expression of ADPN and its receptor are also increased. To study the effects of feed restriction on ADPN and lipid metabolism, broilers were fasted for 12 h and refeed for 2 h. The results showed that fasting decreased the concentration of triglyceride (TG) (P < 0.05) and total cholesterol (TCHO) (P < 0.05) in plasma. The mRNA expression of ADPN in the liver (P < 0.05), breast (P < 0.05) and thigh (P < 0.05), and the mRNA expression of ADPNR1 in the liver (P < 0.05) and duodenum (P < 0.05) were significantly increased in the Fasted group. All above phenomena were recovered after refeeding, suggesting that feed restriction may promote the utilization of fatty acids in active metabolism tissues through ADPN, to guarantee the energy homeostasis of the body. However, the AMP-activated protein kinase (AMPK) signaling pathway and hepatic lipid metabolism were not necessary to cause the above changes under this experimental condition.
format	article
author	Jiangxue Cai Qingmei Hu Hai Lin Jingpeng Zhao Hongchao Jiao Xiaojuan Wang
author_facet	Jiangxue Cai Qingmei Hu Hai Lin Jingpeng Zhao Hongchao Jiao Xiaojuan Wang
author_sort	Jiangxue Cai
title	Adiponectin/adiponectin receptors mRNA expression profiles in chickens and their response to feed restriction
title_short	Adiponectin/adiponectin receptors mRNA expression profiles in chickens and their response to feed restriction
title_full	Adiponectin/adiponectin receptors mRNA expression profiles in chickens and their response to feed restriction
title_fullStr	Adiponectin/adiponectin receptors mRNA expression profiles in chickens and their response to feed restriction
title_full_unstemmed	Adiponectin/adiponectin receptors mRNA expression profiles in chickens and their response to feed restriction
title_sort	adiponectin/adiponectin receptors mrna expression profiles in chickens and their response to feed restriction
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a8a7d9ea13fb4d7ca503ff05910e7a08
work_keys_str_mv	AT jiangxuecai adiponectinadiponectinreceptorsmrnaexpressionprofilesinchickensandtheirresponsetofeedrestriction AT qingmeihu adiponectinadiponectinreceptorsmrnaexpressionprofilesinchickensandtheirresponsetofeedrestriction AT hailin adiponectinadiponectinreceptorsmrnaexpressionprofilesinchickensandtheirresponsetofeedrestriction AT jingpengzhao adiponectinadiponectinreceptorsmrnaexpressionprofilesinchickensandtheirresponsetofeedrestriction AT hongchaojiao adiponectinadiponectinreceptorsmrnaexpressionprofilesinchickensandtheirresponsetofeedrestriction AT xiaojuanwang adiponectinadiponectinreceptorsmrnaexpressionprofilesinchickensandtheirresponsetofeedrestriction
_version_	1718416053417017344

Adiponectin/adiponectin receptors mRNA expression profiles in chickens and their response to feed restriction

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