MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

BRCA2-deficient cells fail to complete replication in S-phase, which results in DNA bridges and chromosome mis-segregation at mitosis. Here the authors show that MUS81 helps BRCA2-deficient cells survive replication stress by activating mitotic DNA synthesis and resolving mitotic DNA bridges.

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Autores principales: Xianning Lai, Ronan Broderick, Valérie Bergoglio, Jutta Zimmer, Sophie Badie, Wojciech Niedzwiedz, Jean-Sébastien Hoffmann, Madalena Tarsounas
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/a8a9dca4e29c43adad08bdc9e4343805
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spelling oai:doaj.org-article:a8a9dca4e29c43adad08bdc9e43438052021-12-02T14:40:35ZMUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells10.1038/ncomms159832041-1723https://doaj.org/article/a8a9dca4e29c43adad08bdc9e43438052017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15983https://doaj.org/toc/2041-1723BRCA2-deficient cells fail to complete replication in S-phase, which results in DNA bridges and chromosome mis-segregation at mitosis. Here the authors show that MUS81 helps BRCA2-deficient cells survive replication stress by activating mitotic DNA synthesis and resolving mitotic DNA bridges.Xianning LaiRonan BroderickValérie BergoglioJutta ZimmerSophie BadieWojciech NiedzwiedzJean-Sébastien HoffmannMadalena TarsounasNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xianning Lai
Ronan Broderick
Valérie Bergoglio
Jutta Zimmer
Sophie Badie
Wojciech Niedzwiedz
Jean-Sébastien Hoffmann
Madalena Tarsounas
MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
description BRCA2-deficient cells fail to complete replication in S-phase, which results in DNA bridges and chromosome mis-segregation at mitosis. Here the authors show that MUS81 helps BRCA2-deficient cells survive replication stress by activating mitotic DNA synthesis and resolving mitotic DNA bridges.
format article
author Xianning Lai
Ronan Broderick
Valérie Bergoglio
Jutta Zimmer
Sophie Badie
Wojciech Niedzwiedz
Jean-Sébastien Hoffmann
Madalena Tarsounas
author_facet Xianning Lai
Ronan Broderick
Valérie Bergoglio
Jutta Zimmer
Sophie Badie
Wojciech Niedzwiedz
Jean-Sébastien Hoffmann
Madalena Tarsounas
author_sort Xianning Lai
title MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
title_short MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
title_full MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
title_fullStr MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
title_full_unstemmed MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
title_sort mus81 nuclease activity is essential for replication stress tolerance and chromosome segregation in brca2-deficient cells
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/a8a9dca4e29c43adad08bdc9e4343805
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AT ronanbroderick mus81nucleaseactivityisessentialforreplicationstresstoleranceandchromosomesegregationinbrca2deficientcells
AT valeriebergoglio mus81nucleaseactivityisessentialforreplicationstresstoleranceandchromosomesegregationinbrca2deficientcells
AT juttazimmer mus81nucleaseactivityisessentialforreplicationstresstoleranceandchromosomesegregationinbrca2deficientcells
AT sophiebadie mus81nucleaseactivityisessentialforreplicationstresstoleranceandchromosomesegregationinbrca2deficientcells
AT wojciechniedzwiedz mus81nucleaseactivityisessentialforreplicationstresstoleranceandchromosomesegregationinbrca2deficientcells
AT jeansebastienhoffmann mus81nucleaseactivityisessentialforreplicationstresstoleranceandchromosomesegregationinbrca2deficientcells
AT madalenatarsounas mus81nucleaseactivityisessentialforreplicationstresstoleranceandchromosomesegregationinbrca2deficientcells
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