Stretching of the back improves gait, mechanical sensitivity and connective tissue inflammation in a rodent model.

The role played by nonspecialized connective tissues in chronic non-specific low back pain is not well understood. In a recent ultrasound study, human subjects with chronic low back pain had altered connective tissue structure compared to human subjects without low back pain, suggesting the presence...

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Autores principales:	Sarah M Corey, Margaret A Vizzard, Nicole A Bouffard, Gary J Badger, Helene M Langevin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8ab138178294690a7c9fea014dada19
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spelling	oai:doaj.org-article:a8ab138178294690a7c9fea014dada192021-11-18T07:30:45ZStretching of the back improves gait, mechanical sensitivity and connective tissue inflammation in a rodent model.1932-620310.1371/journal.pone.0029831https://doaj.org/article/a8ab138178294690a7c9fea014dada192012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22238664/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The role played by nonspecialized connective tissues in chronic non-specific low back pain is not well understood. In a recent ultrasound study, human subjects with chronic low back pain had altered connective tissue structure compared to human subjects without low back pain, suggesting the presence of inflammation and/or fibrosis in the low back pain subjects. Mechanical input in the form of static tissue stretch has been shown in vitro and in vivo to have anti-inflammatory and anti-fibrotic effects. To better understand the pathophysiology of lumbar nonspecialized connective tissue as well as potential mechanisms underlying therapeutic effects of tissue stretch, we developed a carrageenan-induced inflammation model in the low back of a rodent. Induction of inflammation in the lumbar connective tissues resulted in altered gait, increased mechanical sensitivity of the tissues of the low back, and local macrophage infiltration. Mechanical input was then applied to this model as in vivo tissue stretch for 10 minutes twice a day for 12 days. In vivo tissue stretch mitigated the inflammation-induced changes leading to restored stride length and intrastep distance, decreased mechanical sensitivity of the back and reduced macrophage expression in the nonspecialized connective tissues of the low back. This study highlights the need for further investigation into the contribution of connective tissue to low back pain and the need for a better understanding of how interventions involving mechanical stretch could provide maximal therapeutic benefit. This tissue stretch research is relevant to body-based treatments such as yoga or massage, and to some stretch techniques used with physical therapy.Sarah M CoreyMargaret A VizzardNicole A BouffardGary J BadgerHelene M LangevinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e29831 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah M Corey Margaret A Vizzard Nicole A Bouffard Gary J Badger Helene M Langevin Stretching of the back improves gait, mechanical sensitivity and connective tissue inflammation in a rodent model.
description	The role played by nonspecialized connective tissues in chronic non-specific low back pain is not well understood. In a recent ultrasound study, human subjects with chronic low back pain had altered connective tissue structure compared to human subjects without low back pain, suggesting the presence of inflammation and/or fibrosis in the low back pain subjects. Mechanical input in the form of static tissue stretch has been shown in vitro and in vivo to have anti-inflammatory and anti-fibrotic effects. To better understand the pathophysiology of lumbar nonspecialized connective tissue as well as potential mechanisms underlying therapeutic effects of tissue stretch, we developed a carrageenan-induced inflammation model in the low back of a rodent. Induction of inflammation in the lumbar connective tissues resulted in altered gait, increased mechanical sensitivity of the tissues of the low back, and local macrophage infiltration. Mechanical input was then applied to this model as in vivo tissue stretch for 10 minutes twice a day for 12 days. In vivo tissue stretch mitigated the inflammation-induced changes leading to restored stride length and intrastep distance, decreased mechanical sensitivity of the back and reduced macrophage expression in the nonspecialized connective tissues of the low back. This study highlights the need for further investigation into the contribution of connective tissue to low back pain and the need for a better understanding of how interventions involving mechanical stretch could provide maximal therapeutic benefit. This tissue stretch research is relevant to body-based treatments such as yoga or massage, and to some stretch techniques used with physical therapy.
format	article
author	Sarah M Corey Margaret A Vizzard Nicole A Bouffard Gary J Badger Helene M Langevin
author_facet	Sarah M Corey Margaret A Vizzard Nicole A Bouffard Gary J Badger Helene M Langevin
author_sort	Sarah M Corey
title	Stretching of the back improves gait, mechanical sensitivity and connective tissue inflammation in a rodent model.
title_short	Stretching of the back improves gait, mechanical sensitivity and connective tissue inflammation in a rodent model.
title_full	Stretching of the back improves gait, mechanical sensitivity and connective tissue inflammation in a rodent model.
title_fullStr	Stretching of the back improves gait, mechanical sensitivity and connective tissue inflammation in a rodent model.
title_full_unstemmed	Stretching of the back improves gait, mechanical sensitivity and connective tissue inflammation in a rodent model.
title_sort	stretching of the back improves gait, mechanical sensitivity and connective tissue inflammation in a rodent model.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a8ab138178294690a7c9fea014dada19
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Stretching of the back improves gait, mechanical sensitivity and connective tissue inflammation in a rodent model.

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