Anodal tDCS augments and preserves working memory beyond time-on-task deficits

Abstract Transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex (DLPFC) has been shown to promote working memory (WM), however, its efficacy against time-on-task-related performance decline and associated cognitive fatigue remains uncertain. This study examined the...

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Autores principales:	Rohith Karthikeyan, Meredith R. Smoot, Ranjana K. Mehta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8ab6b439ced4422946c3867ec362e09
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spelling	oai:doaj.org-article:a8ab6b439ced4422946c3867ec362e092021-12-02T18:51:15ZAnodal tDCS augments and preserves working memory beyond time-on-task deficits10.1038/s41598-021-98636-y2045-2322https://doaj.org/article/a8ab6b439ced4422946c3867ec362e092021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98636-yhttps://doaj.org/toc/2045-2322Abstract Transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex (DLPFC) has been shown to promote working memory (WM), however, its efficacy against time-on-task-related performance decline and associated cognitive fatigue remains uncertain. This study examined the impact of anodal tDCS of the left DLPFC on performance during a fatiguing visuospatial WM test. We adopted a repeated measures design, where 32 healthy adults (16 female), underwent anodal, control and sham tDCS on separate days. They completed an hour long two-back test, with stimulation intensity, onset, and duration set at 1 mA, at the 20th minute for 10 minutes respectively. Task performance, subjective responses, and heart rate variability (HRV) were captured during the experiment. Anodal tDCS substantially improved WM relative to sham tDCS and control in both sexes. These benefits lasted beyond the stimulation interval, and were unique across performance measures. However, no perceptual changes in subjective effort or fatigue levels were noted between conditions, although participants reported greater discomfort during stimulation. While mood and sleepiness changed with time-on-task, reflecting fatigue, these were largely similar across conditions. HRV increased under anodal tDCS and control, and plateaued under sham tDCS. We found that short duration anodal tDCS at 1 mA was an effective countermeasure to time-on-task deficits during a visuospatial two-back task, with enhancement and preservation of WM capacity. However, these improvements were not available at a perceptual level. Therefore, wider investigations are necessary to determine “how” such solutions will be operationalized in the field, especially within human-centered systems.Rohith KarthikeyanMeredith R. SmootRanjana K. MehtaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rohith Karthikeyan Meredith R. Smoot Ranjana K. Mehta Anodal tDCS augments and preserves working memory beyond time-on-task deficits
description	Abstract Transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex (DLPFC) has been shown to promote working memory (WM), however, its efficacy against time-on-task-related performance decline and associated cognitive fatigue remains uncertain. This study examined the impact of anodal tDCS of the left DLPFC on performance during a fatiguing visuospatial WM test. We adopted a repeated measures design, where 32 healthy adults (16 female), underwent anodal, control and sham tDCS on separate days. They completed an hour long two-back test, with stimulation intensity, onset, and duration set at 1 mA, at the 20th minute for 10 minutes respectively. Task performance, subjective responses, and heart rate variability (HRV) were captured during the experiment. Anodal tDCS substantially improved WM relative to sham tDCS and control in both sexes. These benefits lasted beyond the stimulation interval, and were unique across performance measures. However, no perceptual changes in subjective effort or fatigue levels were noted between conditions, although participants reported greater discomfort during stimulation. While mood and sleepiness changed with time-on-task, reflecting fatigue, these were largely similar across conditions. HRV increased under anodal tDCS and control, and plateaued under sham tDCS. We found that short duration anodal tDCS at 1 mA was an effective countermeasure to time-on-task deficits during a visuospatial two-back task, with enhancement and preservation of WM capacity. However, these improvements were not available at a perceptual level. Therefore, wider investigations are necessary to determine “how” such solutions will be operationalized in the field, especially within human-centered systems.
format	article
author	Rohith Karthikeyan Meredith R. Smoot Ranjana K. Mehta
author_facet	Rohith Karthikeyan Meredith R. Smoot Ranjana K. Mehta
author_sort	Rohith Karthikeyan
title	Anodal tDCS augments and preserves working memory beyond time-on-task deficits
title_short	Anodal tDCS augments and preserves working memory beyond time-on-task deficits
title_full	Anodal tDCS augments and preserves working memory beyond time-on-task deficits
title_fullStr	Anodal tDCS augments and preserves working memory beyond time-on-task deficits
title_full_unstemmed	Anodal tDCS augments and preserves working memory beyond time-on-task deficits
title_sort	anodal tdcs augments and preserves working memory beyond time-on-task deficits
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8ab6b439ced4422946c3867ec362e09
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Anodal tDCS augments and preserves working memory beyond time-on-task deficits

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