Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity

SARS-CoV-2 induces mild infection in ferret model. Here, Ryan et al. characterise optimal infection dosage inducing upper respiratory tract (UTR) viral shedding, progression time of viral shedding, and pathology in ferrets and finally provide evidence for protection after re-challenge.

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Autores principales:	Kathryn A. Ryan, Kevin R. Bewley, Susan A. Fotheringham, Gillian S. Slack, Phillip Brown, Yper Hall, Nadina I. Wand, Anthony C. Marriott, Breeze E. Cavell, Julia A. Tree, Lauren Allen, Marilyn J. Aram, Thomas J. Bean, Emily Brunt, Karen R. Buttigieg, Daniel P. Carter, Rebecca Cobb, Naomi S. Coombes, Steve J. Findlay-Wilson, Kerry J. Godwin, Karen E. Gooch, Jade Gouriet, Rachel Halkerston, Debbie J. Harris, Thomas H. Hender, Holly E. Humphries, Laura Hunter, Catherine M. K. Ho, Chelsea L. Kennard, Stephanie Leung, Stephanie Longet, Didier Ngabo, Karen L. Osman, Jemma Paterson, Elizabeth J. Penn, Steven T. Pullan, Emma Rayner, Oliver Skinner, Kimberley Steeds, Irene Taylor, Tom Tipton, Stephen Thomas, Carrie Turner, Robert J. Watson, Nathan R. Wiblin, Sue Charlton, Bassam Hallis, Julian A. Hiscox, Simon Funnell, Mike J. Dennis, Catherine J. Whittaker, Michael G. Catton, Julian Druce, Francisco J. Salguero, Miles W. Carroll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a8afc90cbc2f4422be7dc5bc8923c3cf
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spelling	oai:doaj.org-article:a8afc90cbc2f4422be7dc5bc8923c3cf2021-12-02T11:56:18ZDose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity10.1038/s41467-020-20439-y2041-1723https://doaj.org/article/a8afc90cbc2f4422be7dc5bc8923c3cf2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20439-yhttps://doaj.org/toc/2041-1723SARS-CoV-2 induces mild infection in ferret model. Here, Ryan et al. characterise optimal infection dosage inducing upper respiratory tract (UTR) viral shedding, progression time of viral shedding, and pathology in ferrets and finally provide evidence for protection after re-challenge.Kathryn A. RyanKevin R. BewleySusan A. FotheringhamGillian S. SlackPhillip BrownYper HallNadina I. WandAnthony C. MarriottBreeze E. CavellJulia A. TreeLauren AllenMarilyn J. AramThomas J. BeanEmily BruntKaren R. ButtigiegDaniel P. CarterRebecca CobbNaomi S. CoombesSteve J. Findlay-WilsonKerry J. GodwinKaren E. GoochJade GourietRachel HalkerstonDebbie J. HarrisThomas H. HenderHolly E. HumphriesLaura HunterCatherine M. K. HoChelsea L. KennardStephanie LeungStephanie LongetDidier NgaboKaren L. OsmanJemma PatersonElizabeth J. PennSteven T. PullanEmma RaynerOliver SkinnerKimberley SteedsIrene TaylorTom TiptonStephen ThomasCarrie TurnerRobert J. WatsonNathan R. WiblinSue CharltonBassam HallisJulian A. HiscoxSimon FunnellMike J. DennisCatherine J. WhittakerMichael G. CattonJulian DruceFrancisco J. SalgueroMiles W. CarrollNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kathryn A. Ryan Kevin R. Bewley Susan A. Fotheringham Gillian S. Slack Phillip Brown Yper Hall Nadina I. Wand Anthony C. Marriott Breeze E. Cavell Julia A. Tree Lauren Allen Marilyn J. Aram Thomas J. Bean Emily Brunt Karen R. Buttigieg Daniel P. Carter Rebecca Cobb Naomi S. Coombes Steve J. Findlay-Wilson Kerry J. Godwin Karen E. Gooch Jade Gouriet Rachel Halkerston Debbie J. Harris Thomas H. Hender Holly E. Humphries Laura Hunter Catherine M. K. Ho Chelsea L. Kennard Stephanie Leung Stephanie Longet Didier Ngabo Karen L. Osman Jemma Paterson Elizabeth J. Penn Steven T. Pullan Emma Rayner Oliver Skinner Kimberley Steeds Irene Taylor Tom Tipton Stephen Thomas Carrie Turner Robert J. Watson Nathan R. Wiblin Sue Charlton Bassam Hallis Julian A. Hiscox Simon Funnell Mike J. Dennis Catherine J. Whittaker Michael G. Catton Julian Druce Francisco J. Salguero Miles W. Carroll Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
description	SARS-CoV-2 induces mild infection in ferret model. Here, Ryan et al. characterise optimal infection dosage inducing upper respiratory tract (UTR) viral shedding, progression time of viral shedding, and pathology in ferrets and finally provide evidence for protection after re-challenge.
format	article
author	Kathryn A. Ryan Kevin R. Bewley Susan A. Fotheringham Gillian S. Slack Phillip Brown Yper Hall Nadina I. Wand Anthony C. Marriott Breeze E. Cavell Julia A. Tree Lauren Allen Marilyn J. Aram Thomas J. Bean Emily Brunt Karen R. Buttigieg Daniel P. Carter Rebecca Cobb Naomi S. Coombes Steve J. Findlay-Wilson Kerry J. Godwin Karen E. Gooch Jade Gouriet Rachel Halkerston Debbie J. Harris Thomas H. Hender Holly E. Humphries Laura Hunter Catherine M. K. Ho Chelsea L. Kennard Stephanie Leung Stephanie Longet Didier Ngabo Karen L. Osman Jemma Paterson Elizabeth J. Penn Steven T. Pullan Emma Rayner Oliver Skinner Kimberley Steeds Irene Taylor Tom Tipton Stephen Thomas Carrie Turner Robert J. Watson Nathan R. Wiblin Sue Charlton Bassam Hallis Julian A. Hiscox Simon Funnell Mike J. Dennis Catherine J. Whittaker Michael G. Catton Julian Druce Francisco J. Salguero Miles W. Carroll
author_facet	Kathryn A. Ryan Kevin R. Bewley Susan A. Fotheringham Gillian S. Slack Phillip Brown Yper Hall Nadina I. Wand Anthony C. Marriott Breeze E. Cavell Julia A. Tree Lauren Allen Marilyn J. Aram Thomas J. Bean Emily Brunt Karen R. Buttigieg Daniel P. Carter Rebecca Cobb Naomi S. Coombes Steve J. Findlay-Wilson Kerry J. Godwin Karen E. Gooch Jade Gouriet Rachel Halkerston Debbie J. Harris Thomas H. Hender Holly E. Humphries Laura Hunter Catherine M. K. Ho Chelsea L. Kennard Stephanie Leung Stephanie Longet Didier Ngabo Karen L. Osman Jemma Paterson Elizabeth J. Penn Steven T. Pullan Emma Rayner Oliver Skinner Kimberley Steeds Irene Taylor Tom Tipton Stephen Thomas Carrie Turner Robert J. Watson Nathan R. Wiblin Sue Charlton Bassam Hallis Julian A. Hiscox Simon Funnell Mike J. Dennis Catherine J. Whittaker Michael G. Catton Julian Druce Francisco J. Salguero Miles W. Carroll
author_sort	Kathryn A. Ryan
title	Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
title_short	Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
title_full	Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
title_fullStr	Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
title_full_unstemmed	Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
title_sort	dose-dependent response to infection with sars-cov-2 in the ferret model and evidence of protective immunity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8afc90cbc2f4422be7dc5bc8923c3cf
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Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity

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