Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system.

Patients with post-stress pathologies display the signs of inflammation in the peripheral blood as well as in the brain. The mechanisms of such post-stress neuroimmune changes, their contribution to the behavior, the relationship of the intensity of inflammation with genetically determined features...

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Autores principales:	I G Shalaginova, O P Tuchina, M V Sidorova, A S Levina, D A-A Khlebaeva, A I Vaido, N A Dyuzhikova
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8aff5edd9624b71a8751a7e2e7a03b2
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spelling	oai:doaj.org-article:a8aff5edd9624b71a8751a7e2e7a03b22021-12-02T20:08:53ZEffects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system.1932-620310.1371/journal.pone.0255380https://doaj.org/article/a8aff5edd9624b71a8751a7e2e7a03b22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255380https://doaj.org/toc/1932-6203Patients with post-stress pathologies display the signs of inflammation in the peripheral blood as well as in the brain. The mechanisms of such post-stress neuroimmune changes, their contribution to the behavior, the relationship of the intensity of inflammation with genetically determined features have not been clarified. The goal of this work was to evaluate the dynamics of post-stress inflammation in the blood and hippocampus of rats which differ in level of excitability of the nervous system. Rats of two strains (high/low excitability threshold) were subjected to stress according to the K. Hecht protocol and their behavior, neutrophil:lymphocyte ratio and the number of Iba+ cells in the hippocampus were analysed 24 hours, 7 and 24 days after stress exposure. Highly excitable animals show an increase in anxiety-like behavior, in the number of neutrophils compared to lymphocytes as well as in the number of Iba1+ cells in CA1, CA3 and DG areas of the hippocampus in response to stress. Thus, hereditary high excitability of the nervous system is a possible risk factor for the development of post-stress pathologies.I G ShalaginovaO P TuchinaM V SidorovaA S LevinaD A-A KhlebaevaA I VaidoN A DyuzhikovaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255380 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q I G Shalaginova O P Tuchina M V Sidorova A S Levina D A-A Khlebaeva A I Vaido N A Dyuzhikova Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system.
description	Patients with post-stress pathologies display the signs of inflammation in the peripheral blood as well as in the brain. The mechanisms of such post-stress neuroimmune changes, their contribution to the behavior, the relationship of the intensity of inflammation with genetically determined features have not been clarified. The goal of this work was to evaluate the dynamics of post-stress inflammation in the blood and hippocampus of rats which differ in level of excitability of the nervous system. Rats of two strains (high/low excitability threshold) were subjected to stress according to the K. Hecht protocol and their behavior, neutrophil:lymphocyte ratio and the number of Iba+ cells in the hippocampus were analysed 24 hours, 7 and 24 days after stress exposure. Highly excitable animals show an increase in anxiety-like behavior, in the number of neutrophils compared to lymphocytes as well as in the number of Iba1+ cells in CA1, CA3 and DG areas of the hippocampus in response to stress. Thus, hereditary high excitability of the nervous system is a possible risk factor for the development of post-stress pathologies.
format	article
author	I G Shalaginova O P Tuchina M V Sidorova A S Levina D A-A Khlebaeva A I Vaido N A Dyuzhikova
author_facet	I G Shalaginova O P Tuchina M V Sidorova A S Levina D A-A Khlebaeva A I Vaido N A Dyuzhikova
author_sort	I G Shalaginova
title	Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system.
title_short	Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system.
title_full	Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system.
title_fullStr	Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system.
title_full_unstemmed	Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system.
title_sort	effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a8aff5edd9624b71a8751a7e2e7a03b2
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Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system.

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