СLINICAL EFFICIENCY OF STATINS IN RHEUMATOID ARTHRITIS: A PILOT STUDY
Abstract. Statins are widely used to lower lipid levels and prevent cardiovascular disease. Recently described anti-inflammatory and immunomodulating properties of statins substantiate their application as a potentially novel treatment for autoimmune diseases. We evaluated efficacy and safety of sim...
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| Auteurs principaux: | , , , , |
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| Format: | article |
| Langue: | RU |
| Publié: |
SPb RAACI
2014
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| Accès en ligne: | https://doaj.org/article/a8b4dce1490d4351a17100af9b57c3ed |
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| Résumé: | Abstract. Statins are widely used to lower lipid levels and prevent cardiovascular disease. Recently described anti-inflammatory and immunomodulating properties of statins substantiate their application as a potentially novel treatment for autoimmune diseases. We evaluated efficacy and safety of simvastatin (40 mg daily) in patients with active rheumatoid arthritis (RA), as a supplement to stable doses of disease-modifying antirheumatic drugs. After 12 weeks of treatment, there was registered a significant decrease in disease activity score (by 0.89 points), improvement of life quality, and attenuation of pain levels. To confirm efficacy and safety of simvastatin in active RA, a large-scale controlled randomized study should be performed. |
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