СLINICAL EFFICIENCY OF STATINS IN RHEUMATOID ARTHRITIS: A PILOT STUDY
Abstract. Statins are widely used to lower lipid levels and prevent cardiovascular disease. Recently described anti-inflammatory and immunomodulating properties of statins substantiate their application as a potentially novel treatment for autoimmune diseases. We evaluated efficacy and safety of sim...
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SPb RAACI
2014
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oai:doaj.org-article:a8b4dce1490d4351a17100af9b57c3ed2021-11-18T08:03:39ZСLINICAL EFFICIENCY OF STATINS IN RHEUMATOID ARTHRITIS: A PILOT STUDY1563-06252313-741X10.15789/1563-0625-2007-4-5-505-508https://doaj.org/article/a8b4dce1490d4351a17100af9b57c3ed2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/229https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Statins are widely used to lower lipid levels and prevent cardiovascular disease. Recently described anti-inflammatory and immunomodulating properties of statins substantiate their application as a potentially novel treatment for autoimmune diseases. We evaluated efficacy and safety of simvastatin (40 mg daily) in patients with active rheumatoid arthritis (RA), as a supplement to stable doses of disease-modifying antirheumatic drugs. After 12 weeks of treatment, there was registered a significant decrease in disease activity score (by 0.89 points), improvement of life quality, and attenuation of pain levels. To confirm efficacy and safety of simvastatin in active RA, a large-scale controlled randomized study should be performed.I. V. ShirinskyO. I. ZheltovaN. Yu. SolovievaV. S. ShirinskyV. A. KozlovSPb RAACIarticlerheumatoid arthritissimvastatinstatinstreatmentImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 4-5, Pp 505-508 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
RU |
| topic |
rheumatoid arthritis simvastatin statins treatment Immunologic diseases. Allergy RC581-607 |
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rheumatoid arthritis simvastatin statins treatment Immunologic diseases. Allergy RC581-607 I. V. Shirinsky O. I. Zheltova N. Yu. Solovieva V. S. Shirinsky V. A. Kozlov СLINICAL EFFICIENCY OF STATINS IN RHEUMATOID ARTHRITIS: A PILOT STUDY |
| description |
Abstract. Statins are widely used to lower lipid levels and prevent cardiovascular disease. Recently described anti-inflammatory and immunomodulating properties of statins substantiate their application as a potentially novel treatment for autoimmune diseases. We evaluated efficacy and safety of simvastatin (40 mg daily) in patients with active rheumatoid arthritis (RA), as a supplement to stable doses of disease-modifying antirheumatic drugs. After 12 weeks of treatment, there was registered a significant decrease in disease activity score (by 0.89 points), improvement of life quality, and attenuation of pain levels. To confirm efficacy and safety of simvastatin in active RA, a large-scale controlled randomized study should be performed. |
| format |
article |
| author |
I. V. Shirinsky O. I. Zheltova N. Yu. Solovieva V. S. Shirinsky V. A. Kozlov |
| author_facet |
I. V. Shirinsky O. I. Zheltova N. Yu. Solovieva V. S. Shirinsky V. A. Kozlov |
| author_sort |
I. V. Shirinsky |
| title |
СLINICAL EFFICIENCY OF STATINS IN RHEUMATOID ARTHRITIS: A PILOT STUDY |
| title_short |
СLINICAL EFFICIENCY OF STATINS IN RHEUMATOID ARTHRITIS: A PILOT STUDY |
| title_full |
СLINICAL EFFICIENCY OF STATINS IN RHEUMATOID ARTHRITIS: A PILOT STUDY |
| title_fullStr |
СLINICAL EFFICIENCY OF STATINS IN RHEUMATOID ARTHRITIS: A PILOT STUDY |
| title_full_unstemmed |
СLINICAL EFFICIENCY OF STATINS IN RHEUMATOID ARTHRITIS: A PILOT STUDY |
| title_sort |
сlinical efficiency of statins in rheumatoid arthritis: a pilot study |
| publisher |
SPb RAACI |
| publishDate |
2014 |
| url |
https://doaj.org/article/a8b4dce1490d4351a17100af9b57c3ed |
| work_keys_str_mv |
AT ivshirinsky slinicalefficiencyofstatinsinrheumatoidarthritisapilotstudy AT oizheltova slinicalefficiencyofstatinsinrheumatoidarthritisapilotstudy AT nyusolovieva slinicalefficiencyofstatinsinrheumatoidarthritisapilotstudy AT vsshirinsky slinicalefficiencyofstatinsinrheumatoidarthritisapilotstudy AT vakozlov slinicalefficiencyofstatinsinrheumatoidarthritisapilotstudy |
| _version_ |
1718422562392768512 |