Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data

Abstract Drug-resistant epilepsy is a diagnostic and therapeutic challenge, mainly in patients with negative MRI findings. State-of-the-art imaging methods complement standard epilepsy protocols with new information and help epileptologists to increase the reliability of their decisions. In this stu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Martin Gajdoš, Pavel Říha, Martin Kojan, Irena Doležalová, Henk J. M. M. Mutsaerts, Jan Petr, Ivan Rektor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8b6245cd9404b2381b826eeb33c9823
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a8b6245cd9404b2381b826eeb33c9823
record_format	dspace
spelling	oai:doaj.org-article:a8b6245cd9404b2381b826eeb33c98232021-12-02T15:49:39ZEpileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data10.1038/s41598-021-89774-42045-2322https://doaj.org/article/a8b6245cd9404b2381b826eeb33c98232021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89774-4https://doaj.org/toc/2045-2322Abstract Drug-resistant epilepsy is a diagnostic and therapeutic challenge, mainly in patients with negative MRI findings. State-of-the-art imaging methods complement standard epilepsy protocols with new information and help epileptologists to increase the reliability of their decisions. In this study, we investigate whether arterial spin labeling (ASL) perfusion MRI can help localize the epileptogenic zone (EZ). To that end, we developed an image processing method to detect the EZ as an area with hypoperfusion relative to the contralateral unaffected side, using subject-specific thresholding of the asymmetry index in ASL images. We demonstrated three thresholding criteria (termed minimal product criterion, minimal distance criterion, and elbow criterion) on 29 patients with MRI-negative epilepsy (age 32.98 ± 10.4 years). The minimal product criterion showed optimal results in terms of positive predictive value (mean 0.12 in postoperative group and 0.22 in preoperative group) and true positive rate (mean 0.71 in postoperative group and 1.82 in preoperative group). Additionally, we found high accuracy in determining the EZ side (mean 0.86 in postoperative group and 0.73 in preoperative group out of 1.00). ASL can be easily incorporated into the standard presurgical MR protocol, and it provides an additional benefit in EZ localization.Martin GajdošPavel ŘíhaMartin KojanIrena DoležalováHenk J. M. M. MutsaertsJan PetrIvan RektorNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martin Gajdoš Pavel Říha Martin Kojan Irena Doležalová Henk J. M. M. Mutsaerts Jan Petr Ivan Rektor Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data
description	Abstract Drug-resistant epilepsy is a diagnostic and therapeutic challenge, mainly in patients with negative MRI findings. State-of-the-art imaging methods complement standard epilepsy protocols with new information and help epileptologists to increase the reliability of their decisions. In this study, we investigate whether arterial spin labeling (ASL) perfusion MRI can help localize the epileptogenic zone (EZ). To that end, we developed an image processing method to detect the EZ as an area with hypoperfusion relative to the contralateral unaffected side, using subject-specific thresholding of the asymmetry index in ASL images. We demonstrated three thresholding criteria (termed minimal product criterion, minimal distance criterion, and elbow criterion) on 29 patients with MRI-negative epilepsy (age 32.98 ± 10.4 years). The minimal product criterion showed optimal results in terms of positive predictive value (mean 0.12 in postoperative group and 0.22 in preoperative group) and true positive rate (mean 0.71 in postoperative group and 1.82 in preoperative group). Additionally, we found high accuracy in determining the EZ side (mean 0.86 in postoperative group and 0.73 in preoperative group out of 1.00). ASL can be easily incorporated into the standard presurgical MR protocol, and it provides an additional benefit in EZ localization.
format	article
author	Martin Gajdoš Pavel Říha Martin Kojan Irena Doležalová Henk J. M. M. Mutsaerts Jan Petr Ivan Rektor
author_facet	Martin Gajdoš Pavel Říha Martin Kojan Irena Doležalová Henk J. M. M. Mutsaerts Jan Petr Ivan Rektor
author_sort	Martin Gajdoš
title	Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data
title_short	Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data
title_full	Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data
title_fullStr	Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data
title_full_unstemmed	Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data
title_sort	epileptogenic zone detection in mri negative epilepsy using adaptive thresholding of arterial spin labeling data
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8b6245cd9404b2381b826eeb33c9823
work_keys_str_mv	AT martingajdos epileptogeniczonedetectioninmrinegativeepilepsyusingadaptivethresholdingofarterialspinlabelingdata AT pavelriha epileptogeniczonedetectioninmrinegativeepilepsyusingadaptivethresholdingofarterialspinlabelingdata AT martinkojan epileptogeniczonedetectioninmrinegativeepilepsyusingadaptivethresholdingofarterialspinlabelingdata AT irenadolezalova epileptogeniczonedetectioninmrinegativeepilepsyusingadaptivethresholdingofarterialspinlabelingdata AT henkjmmmutsaerts epileptogeniczonedetectioninmrinegativeepilepsyusingadaptivethresholdingofarterialspinlabelingdata AT janpetr epileptogeniczonedetectioninmrinegativeepilepsyusingadaptivethresholdingofarterialspinlabelingdata AT ivanrektor epileptogeniczonedetectioninmrinegativeepilepsyusingadaptivethresholdingofarterialspinlabelingdata
_version_	1718385709681737728

Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data

Ejemplares similares