The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry

The pathogen Campylobacter jejuni invades intestinal cells after secreting protein effectors into the host cell cytosol via the flagellum. Here, Negretti et al. show that one of these effectors, CiaD, binds to host protein IQGAP1, thus leading to unconstrained activity of small GTPase Rac1, which mo...

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Autores principales:	Nicholas M. Negretti, Christopher R. Gourley, Prabhat K. Talukdar, Geremy Clair, Courtney M. Klappenbach, Cody J. Lauritsen, Joshua N. Adkins, Michael E. Konkel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a8b8eb06bb7146fe925ceebb8d17162e
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spelling	oai:doaj.org-article:a8b8eb06bb7146fe925ceebb8d17162e2021-12-02T13:33:02ZThe Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry10.1038/s41467-021-21579-52041-1723https://doaj.org/article/a8b8eb06bb7146fe925ceebb8d17162e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21579-5https://doaj.org/toc/2041-1723The pathogen Campylobacter jejuni invades intestinal cells after secreting protein effectors into the host cell cytosol via the flagellum. Here, Negretti et al. show that one of these effectors, CiaD, binds to host protein IQGAP1, thus leading to unconstrained activity of small GTPase Rac1, which modulates actin reorganization and bacterial internalization.Nicholas M. NegrettiChristopher R. GourleyPrabhat K. TalukdarGeremy ClairCourtney M. KlappenbachCody J. LauritsenJoshua N. AdkinsMichael E. KonkelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas M. Negretti Christopher R. Gourley Prabhat K. Talukdar Geremy Clair Courtney M. Klappenbach Cody J. Lauritsen Joshua N. Adkins Michael E. Konkel The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry
description	The pathogen Campylobacter jejuni invades intestinal cells after secreting protein effectors into the host cell cytosol via the flagellum. Here, Negretti et al. show that one of these effectors, CiaD, binds to host protein IQGAP1, thus leading to unconstrained activity of small GTPase Rac1, which modulates actin reorganization and bacterial internalization.
format	article
author	Nicholas M. Negretti Christopher R. Gourley Prabhat K. Talukdar Geremy Clair Courtney M. Klappenbach Cody J. Lauritsen Joshua N. Adkins Michael E. Konkel
author_facet	Nicholas M. Negretti Christopher R. Gourley Prabhat K. Talukdar Geremy Clair Courtney M. Klappenbach Cody J. Lauritsen Joshua N. Adkins Michael E. Konkel
author_sort	Nicholas M. Negretti
title	The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry
title_short	The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry
title_full	The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry
title_fullStr	The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry
title_full_unstemmed	The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry
title_sort	campylobacter jejuni ciad effector co-opts the host cell protein iqgap1 to promote cell entry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8b8eb06bb7146fe925ceebb8d17162e
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The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry

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