Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease

Abstract Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used...

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Autores principales:	Alice E. Law, Rebecca K. Shears, Andrea A. Lopez Rodas, Richard K. Grencis, Philip J. Cooper, Daniel R. Neill, Aras Kadioglu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8bb4f2f12d842e99dc75046011d68e1
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spelling	oai:doaj.org-article:a8bb4f2f12d842e99dc75046011d68e12021-12-02T16:35:56ZIntestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease10.1038/s41598-021-86508-42045-2322https://doaj.org/article/a8bb4f2f12d842e99dc75046011d68e12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86508-4https://doaj.org/toc/2045-2322Abstract Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used a mouse co-infection model and clinical data to assess the impact of co-infection on carriage density. Co-infection in mice was associated with increased pneumococcal carriage density and dissemination into lungs. Helminth-infected children also exhibited increased carriage density as compared to uninfected children. Anthelmintic treatment may be a cost-effective method of reducing pneumococcal disease burden in lower-income countries.Alice E. LawRebecca K. ShearsAndrea A. Lopez RodasRichard K. GrencisPhilip J. CooperDaniel R. NeillAras KadiogluNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alice E. Law Rebecca K. Shears Andrea A. Lopez Rodas Richard K. Grencis Philip J. Cooper Daniel R. Neill Aras Kadioglu Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
description	Abstract Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used a mouse co-infection model and clinical data to assess the impact of co-infection on carriage density. Co-infection in mice was associated with increased pneumococcal carriage density and dissemination into lungs. Helminth-infected children also exhibited increased carriage density as compared to uninfected children. Anthelmintic treatment may be a cost-effective method of reducing pneumococcal disease burden in lower-income countries.
format	article
author	Alice E. Law Rebecca K. Shears Andrea A. Lopez Rodas Richard K. Grencis Philip J. Cooper Daniel R. Neill Aras Kadioglu
author_facet	Alice E. Law Rebecca K. Shears Andrea A. Lopez Rodas Richard K. Grencis Philip J. Cooper Daniel R. Neill Aras Kadioglu
author_sort	Alice E. Law
title	Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
title_short	Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
title_full	Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
title_fullStr	Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
title_full_unstemmed	Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
title_sort	intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8bb4f2f12d842e99dc75046011d68e1
work_keys_str_mv	AT aliceelaw intestinalhelminthcoinfectionisanunrecognisedriskfactorforincreasedpneumococcalcarriagedensityandinvasivedisease AT rebeccakshears intestinalhelminthcoinfectionisanunrecognisedriskfactorforincreasedpneumococcalcarriagedensityandinvasivedisease AT andreaalopezrodas intestinalhelminthcoinfectionisanunrecognisedriskfactorforincreasedpneumococcalcarriagedensityandinvasivedisease AT richardkgrencis intestinalhelminthcoinfectionisanunrecognisedriskfactorforincreasedpneumococcalcarriagedensityandinvasivedisease AT philipjcooper intestinalhelminthcoinfectionisanunrecognisedriskfactorforincreasedpneumococcalcarriagedensityandinvasivedisease AT danielrneill intestinalhelminthcoinfectionisanunrecognisedriskfactorforincreasedpneumococcalcarriagedensityandinvasivedisease AT araskadioglu intestinalhelminthcoinfectionisanunrecognisedriskfactorforincreasedpneumococcalcarriagedensityandinvasivedisease
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Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease

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