Improvement of Fractional Flow Reserve after Percutaneous Coronary Intervention Does Not Necessarily Indicate Increased Coronary Flow

Coronary flow is expected to increase by epicardial lesion modification after successful percutaneous coronary intervention (PCI) in stable angina. According to the concept of fractional flow reserve (FFR), the improvement in FFR after PCI reflects the extent of coronary flow increase. However, this...

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Autores principales:	Rikuta Hamaya, Yoshihisa Kanaji, Eisuke Usui, Masahiro Hoshino, Tadashi Murai, Taishi Yonetsu, Tsunekazu Kakuta
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2019
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/a8bc467cf3e14a67b319dd7c74b97378
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spelling	oai:doaj.org-article:a8bc467cf3e14a67b319dd7c74b973782021-12-04T16:01:18ZImprovement of Fractional Flow Reserve after Percutaneous Coronary Intervention Does Not Necessarily Indicate Increased Coronary Flow10.15420/ecr.2018.27.21758-37641758-3756https://doaj.org/article/a8bc467cf3e14a67b319dd7c74b973782019-01-01T00:00:00Zhttps://www.ecrjournal.com/articles/improvement-fractional-flow-reserve-after-percutaneous-coronary-intervention-does-nothttps://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Coronary flow is expected to increase by epicardial lesion modification after successful percutaneous coronary intervention (PCI) in stable angina. According to the concept of fractional flow reserve (FFR), the improvement in FFR after PCI reflects the extent of coronary flow increase. However, this theory assumes that hyperaemic microvascular resistance does not change after PCI, which is being refuted in recent studies. The authors quantitated regional absolute coronary blood flow (ABF) before and after PCI using a thermodilution method and compared it with FFR in 28 patients with stable coronary artery disease who had undergone successful PCI. Although FFR indicated changes in ABF, with a mean difference of −5.5 ml/min, there was no significant relationship between individual changes in FFR and in ABF (R=0.27, p=0.16). The discrepancy was partly explained by changes in microvascular resistance following PCI. These results suggest that changes in FFR do not necessarily indicate an increase in absolute coronary blood flow following PCI in individual patients, although they could be correlated in a cohort level.Rikuta HamayaYoshihisa KanajiEisuke UsuiMasahiro HoshinoTadashi MuraiTaishi YonetsuTsunekazu KakutaRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 14, Iss 1, Pp 10-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Rikuta Hamaya Yoshihisa Kanaji Eisuke Usui Masahiro Hoshino Tadashi Murai Taishi Yonetsu Tsunekazu Kakuta Improvement of Fractional Flow Reserve after Percutaneous Coronary Intervention Does Not Necessarily Indicate Increased Coronary Flow
description	Coronary flow is expected to increase by epicardial lesion modification after successful percutaneous coronary intervention (PCI) in stable angina. According to the concept of fractional flow reserve (FFR), the improvement in FFR after PCI reflects the extent of coronary flow increase. However, this theory assumes that hyperaemic microvascular resistance does not change after PCI, which is being refuted in recent studies. The authors quantitated regional absolute coronary blood flow (ABF) before and after PCI using a thermodilution method and compared it with FFR in 28 patients with stable coronary artery disease who had undergone successful PCI. Although FFR indicated changes in ABF, with a mean difference of −5.5 ml/min, there was no significant relationship between individual changes in FFR and in ABF (R=0.27, p=0.16). The discrepancy was partly explained by changes in microvascular resistance following PCI. These results suggest that changes in FFR do not necessarily indicate an increase in absolute coronary blood flow following PCI in individual patients, although they could be correlated in a cohort level.
format	article
author	Rikuta Hamaya Yoshihisa Kanaji Eisuke Usui Masahiro Hoshino Tadashi Murai Taishi Yonetsu Tsunekazu Kakuta
author_facet	Rikuta Hamaya Yoshihisa Kanaji Eisuke Usui Masahiro Hoshino Tadashi Murai Taishi Yonetsu Tsunekazu Kakuta
author_sort	Rikuta Hamaya
title	Improvement of Fractional Flow Reserve after Percutaneous Coronary Intervention Does Not Necessarily Indicate Increased Coronary Flow
title_short	Improvement of Fractional Flow Reserve after Percutaneous Coronary Intervention Does Not Necessarily Indicate Increased Coronary Flow
title_full	Improvement of Fractional Flow Reserve after Percutaneous Coronary Intervention Does Not Necessarily Indicate Increased Coronary Flow
title_fullStr	Improvement of Fractional Flow Reserve after Percutaneous Coronary Intervention Does Not Necessarily Indicate Increased Coronary Flow
title_full_unstemmed	Improvement of Fractional Flow Reserve after Percutaneous Coronary Intervention Does Not Necessarily Indicate Increased Coronary Flow
title_sort	improvement of fractional flow reserve after percutaneous coronary intervention does not necessarily indicate increased coronary flow
publisher	Radcliffe Medical Media
publishDate	2019
url	https://doaj.org/article/a8bc467cf3e14a67b319dd7c74b97378
work_keys_str_mv	AT rikutahamaya improvementoffractionalflowreserveafterpercutaneouscoronaryinterventiondoesnotnecessarilyindicateincreasedcoronaryflow AT yoshihisakanaji improvementoffractionalflowreserveafterpercutaneouscoronaryinterventiondoesnotnecessarilyindicateincreasedcoronaryflow AT eisukeusui improvementoffractionalflowreserveafterpercutaneouscoronaryinterventiondoesnotnecessarilyindicateincreasedcoronaryflow AT masahirohoshino improvementoffractionalflowreserveafterpercutaneouscoronaryinterventiondoesnotnecessarilyindicateincreasedcoronaryflow AT tadashimurai improvementoffractionalflowreserveafterpercutaneouscoronaryinterventiondoesnotnecessarilyindicateincreasedcoronaryflow AT taishiyonetsu improvementoffractionalflowreserveafterpercutaneouscoronaryinterventiondoesnotnecessarilyindicateincreasedcoronaryflow AT tsunekazukakuta improvementoffractionalflowreserveafterpercutaneouscoronaryinterventiondoesnotnecessarilyindicateincreasedcoronaryflow
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Improvement of Fractional Flow Reserve after Percutaneous Coronary Intervention Does Not Necessarily Indicate Increased Coronary Flow

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