Brd2 inhibits adipogenesis via the ERK1/2 signaling pathway in 3T3-L1 adipocytes.

Brd2 inhibits adipogenesis via the ERK1/2 signaling pathway in 3T3-L1 adipocytes.

Bromodomain-containing protein 2 (Brd2) is a nuclear serine/threonine kinase involved in transcriptional regulation. In 3T3-L1 adipocytes, Brd2 normally co-represses PPARγ (peroxisome proliferator-activated receptor gamma) and inhibits adipogenesis. Here, we show that Brd2 over-expression in preadip...

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Bibliographic Details
Main Authors: Kun Zang, Jingyu Wang, Miaofang Dong, Ruixin Sun, Yuxiong Wang, Yinong Huang, Xiaoxia Liu, Yimin Li, Fangnian Wang, Min Yu
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/a8bfaf15d7c447c0923f95a964d77aef
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