The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice

The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice

Bed nucleus of the stria terminalis (BNST) neurons that synthesize and release the stress neuropeptide corticotropin-releasing factor drive binge alcohol drinking and anxiety. The authors describe a complex feedforward inhibitory PVTVGLUT2-BNSTCRF circuit in mice that plays sex-dependent roles in al...

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Autores principales: Olivia B. Levine, Mary Jane Skelly, John D. Miller, Jean K. Rivera-Irizarry, Sydney A. Rowson, Jeffrey F. DiBerto, Jennifer A. Rinker, Todd E. Thiele, Thomas L. Kash, Kristen E. Pleil
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a8c0c1c246d94234990664f016ba912d
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spelling oai:doaj.org-article:a8c0c1c246d94234990664f016ba912d2021-12-02T19:02:28ZThe paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice10.1038/s41467-021-25368-y2041-1723https://doaj.org/article/a8c0c1c246d94234990664f016ba912d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25368-yhttps://doaj.org/toc/2041-1723Bed nucleus of the stria terminalis (BNST) neurons that synthesize and release the stress neuropeptide corticotropin-releasing factor drive binge alcohol drinking and anxiety. The authors describe a complex feedforward inhibitory PVTVGLUT2-BNSTCRF circuit in mice that plays sex-dependent roles in alcohol drinking and avoidance behavior.Olivia B. LevineMary Jane SkellyJohn D. MillerJean K. Rivera-IrizarrySydney A. RowsonJeffrey F. DiBertoJennifer A. RinkerTodd E. ThieleThomas L. KashKristen E. PleilNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Olivia B. Levine
Mary Jane Skelly
John D. Miller
Jean K. Rivera-Irizarry
Sydney A. Rowson
Jeffrey F. DiBerto
Jennifer A. Rinker
Todd E. Thiele
Thomas L. Kash
Kristen E. Pleil
The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice
description Bed nucleus of the stria terminalis (BNST) neurons that synthesize and release the stress neuropeptide corticotropin-releasing factor drive binge alcohol drinking and anxiety. The authors describe a complex feedforward inhibitory PVTVGLUT2-BNSTCRF circuit in mice that plays sex-dependent roles in alcohol drinking and avoidance behavior.
format article
author Olivia B. Levine
Mary Jane Skelly
John D. Miller
Jean K. Rivera-Irizarry
Sydney A. Rowson
Jeffrey F. DiBerto
Jennifer A. Rinker
Todd E. Thiele
Thomas L. Kash
Kristen E. Pleil
author_facet Olivia B. Levine
Mary Jane Skelly
John D. Miller
Jean K. Rivera-Irizarry
Sydney A. Rowson
Jeffrey F. DiBerto
Jennifer A. Rinker
Todd E. Thiele
Thomas L. Kash
Kristen E. Pleil
author_sort Olivia B. Levine
title The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice
title_short The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice
title_full The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice
title_fullStr The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice
title_full_unstemmed The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice
title_sort paraventricular thalamus provides a polysynaptic brake on limbic crf neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a8c0c1c246d94234990664f016ba912d
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