Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome

Using mouse models of liver fibrosis, Kim et al examined the mechanisms underlying the antifibrotic inhibition of the NLRP3 inflammasome by auranofin. They demonstrated that auranofin-induced inhibition of the NLRP3 inflammasome in bone marrow-derived macrophages and kupffer cells was mediated via i...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Hyun Young Kim, Young Jae Choi, Sang Kyum Kim, Hyunsung Kim, Dae Won Jun, Kyungrok Yoon, Nayoun Kim, Jungwook Hwang, Young-Mi Kim, Sung Chul Lim, Keon Wook Kang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/a8c3d45e9c7849f58380313f0c5a39f7
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:a8c3d45e9c7849f58380313f0c5a39f7
record_format	dspace
spelling	oai:doaj.org-article:a8c3d45e9c7849f58380313f0c5a39f72021-12-02T14:34:01ZAuranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome10.1038/s42003-021-02345-12399-3642https://doaj.org/article/a8c3d45e9c7849f58380313f0c5a39f72021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02345-1https://doaj.org/toc/2399-3642Using mouse models of liver fibrosis, Kim et al examined the mechanisms underlying the antifibrotic inhibition of the NLRP3 inflammasome by auranofin. They demonstrated that auranofin-induced inhibition of the NLRP3 inflammasome in bone marrow-derived macrophages and kupffer cells was mediated via inhibition of the cystine-glutamate antiporter, system Xc, which advances our understanding of the mechanism by which auranofin exerts its therapeutic effects.Hyun Young KimYoung Jae ChoiSang Kyum KimHyunsung KimDae Won JunKyungrok YoonNayoun KimJungwook HwangYoung-Mi KimSung Chul LimKeon Wook KangNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hyun Young Kim Young Jae Choi Sang Kyum Kim Hyunsung Kim Dae Won Jun Kyungrok Yoon Nayoun Kim Jungwook Hwang Young-Mi Kim Sung Chul Lim Keon Wook Kang Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
description	Using mouse models of liver fibrosis, Kim et al examined the mechanisms underlying the antifibrotic inhibition of the NLRP3 inflammasome by auranofin. They demonstrated that auranofin-induced inhibition of the NLRP3 inflammasome in bone marrow-derived macrophages and kupffer cells was mediated via inhibition of the cystine-glutamate antiporter, system Xc, which advances our understanding of the mechanism by which auranofin exerts its therapeutic effects.
format	article
author	Hyun Young Kim Young Jae Choi Sang Kyum Kim Hyunsung Kim Dae Won Jun Kyungrok Yoon Nayoun Kim Jungwook Hwang Young-Mi Kim Sung Chul Lim Keon Wook Kang
author_facet	Hyun Young Kim Young Jae Choi Sang Kyum Kim Hyunsung Kim Dae Won Jun Kyungrok Yoon Nayoun Kim Jungwook Hwang Young-Mi Kim Sung Chul Lim Keon Wook Kang
author_sort	Hyun Young Kim
title	Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
title_short	Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
title_full	Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
title_fullStr	Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
title_full_unstemmed	Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
title_sort	auranofin prevents liver fibrosis by system xc-mediated inhibition of nlrp3 inflammasome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8c3d45e9c7849f58380313f0c5a39f7
work_keys_str_mv	AT hyunyoungkim auranofinpreventsliverfibrosisbysystemxcmediatedinhibitionofnlrp3inflammasome AT youngjaechoi auranofinpreventsliverfibrosisbysystemxcmediatedinhibitionofnlrp3inflammasome AT sangkyumkim auranofinpreventsliverfibrosisbysystemxcmediatedinhibitionofnlrp3inflammasome AT hyunsungkim auranofinpreventsliverfibrosisbysystemxcmediatedinhibitionofnlrp3inflammasome AT daewonjun auranofinpreventsliverfibrosisbysystemxcmediatedinhibitionofnlrp3inflammasome AT kyungrokyoon auranofinpreventsliverfibrosisbysystemxcmediatedinhibitionofnlrp3inflammasome AT nayounkim auranofinpreventsliverfibrosisbysystemxcmediatedinhibitionofnlrp3inflammasome AT jungwookhwang auranofinpreventsliverfibrosisbysystemxcmediatedinhibitionofnlrp3inflammasome AT youngmikim auranofinpreventsliverfibrosisbysystemxcmediatedinhibitionofnlrp3inflammasome AT sungchullim auranofinpreventsliverfibrosisbysystemxcmediatedinhibitionofnlrp3inflammasome AT keonwookkang auranofinpreventsliverfibrosisbysystemxcmediatedinhibitionofnlrp3inflammasome
_version_	1718391149883817984

Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome

Documents similaires