Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome

Using mouse models of liver fibrosis, Kim et al examined the mechanisms underlying the antifibrotic inhibition of the NLRP3 inflammasome by auranofin. They demonstrated that auranofin-induced inhibition of the NLRP3 inflammasome in bone marrow-derived macrophages and kupffer cells was mediated via i...

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Autores principales:	Hyun Young Kim, Young Jae Choi, Sang Kyum Kim, Hyunsung Kim, Dae Won Jun, Kyungrok Yoon, Nayoun Kim, Jungwook Hwang, Young-Mi Kim, Sung Chul Lim, Keon Wook Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a8c3d45e9c7849f58380313f0c5a39f7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:a8c3d45e9c7849f58380313f0c5a39f72021-12-02T14:34:01ZAuranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome10.1038/s42003-021-02345-12399-3642https://doaj.org/article/a8c3d45e9c7849f58380313f0c5a39f72021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02345-1https://doaj.org/toc/2399-3642Using mouse models of liver fibrosis, Kim et al examined the mechanisms underlying the antifibrotic inhibition of the NLRP3 inflammasome by auranofin. They demonstrated that auranofin-induced inhibition of the NLRP3 inflammasome in bone marrow-derived macrophages and kupffer cells was mediated via inhibition of the cystine-glutamate antiporter, system Xc, which advances our understanding of the mechanism by which auranofin exerts its therapeutic effects.Hyun Young KimYoung Jae ChoiSang Kyum KimHyunsung KimDae Won JunKyungrok YoonNayoun KimJungwook HwangYoung-Mi KimSung Chul LimKeon Wook KangNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hyun Young Kim Young Jae Choi Sang Kyum Kim Hyunsung Kim Dae Won Jun Kyungrok Yoon Nayoun Kim Jungwook Hwang Young-Mi Kim Sung Chul Lim Keon Wook Kang Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
description	Using mouse models of liver fibrosis, Kim et al examined the mechanisms underlying the antifibrotic inhibition of the NLRP3 inflammasome by auranofin. They demonstrated that auranofin-induced inhibition of the NLRP3 inflammasome in bone marrow-derived macrophages and kupffer cells was mediated via inhibition of the cystine-glutamate antiporter, system Xc, which advances our understanding of the mechanism by which auranofin exerts its therapeutic effects.
format	article
author	Hyun Young Kim Young Jae Choi Sang Kyum Kim Hyunsung Kim Dae Won Jun Kyungrok Yoon Nayoun Kim Jungwook Hwang Young-Mi Kim Sung Chul Lim Keon Wook Kang
author_facet	Hyun Young Kim Young Jae Choi Sang Kyum Kim Hyunsung Kim Dae Won Jun Kyungrok Yoon Nayoun Kim Jungwook Hwang Young-Mi Kim Sung Chul Lim Keon Wook Kang
author_sort	Hyun Young Kim
title	Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
title_short	Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
title_full	Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
title_fullStr	Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
title_full_unstemmed	Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
title_sort	auranofin prevents liver fibrosis by system xc-mediated inhibition of nlrp3 inflammasome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8c3d45e9c7849f58380313f0c5a39f7
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Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome

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