Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome

Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome

Using mouse models of liver fibrosis, Kim et al examined the mechanisms underlying the antifibrotic inhibition of the NLRP3 inflammasome by auranofin. They demonstrated that auranofin-induced inhibition of the NLRP3 inflammasome in bone marrow-derived macrophages and kupffer cells was mediated via i...

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Bibliographic Details
Main Authors: Hyun Young Kim, Young Jae Choi, Sang Kyum Kim, Hyunsung Kim, Dae Won Jun, Kyungrok Yoon, Nayoun Kim, Jungwook Hwang, Young-Mi Kim, Sung Chul Lim, Keon Wook Kang
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/a8c3d45e9c7849f58380313f0c5a39f7
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