Targeting cancer stem cells by using the nanoparticles

In-Sun Hong,1,2,* Gyu-Beom Jang,1,2,* Hwa-Yong Lee,3 Jeong-Seok Nam1,2 1Laboratory of Tumor Suppressor, Lee Gil Ya Cancer and Diabetes Institute, 2Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, 3The Faculty of Liberal Arts, Jungwon University, Chungbuk, Republic o...

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Autores principales:	Hong IS, Jang GB, Lee HY, Nam JS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a8c524c514144d518d06a9a607fb8b49
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spelling	oai:doaj.org-article:a8c524c514144d518d06a9a607fb8b492021-12-02T03:11:31ZTargeting cancer stem cells by using the nanoparticles1178-2013https://doaj.org/article/a8c524c514144d518d06a9a607fb8b492015-09-01T00:00:00Zhttps://www.dovepress.com/targeting-cancer-stem-cells-by-using-the-nanoparticles-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013In-Sun Hong,1,2,* Gyu-Beom Jang,1,2,* Hwa-Yong Lee,3 Jeong-Seok Nam1,2 1Laboratory of Tumor Suppressor, Lee Gil Ya Cancer and Diabetes Institute, 2Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, 3The Faculty of Liberal Arts, Jungwon University, Chungbuk, Republic of Korea *These authors contributed equally to this work Abstract: Cancer stem cells (CSCs) have been shown to be markedly resistant to conventional cancer treatments such as chemotherapy and radiation therapy. Therefore, therapeutic strategies that selectively target CSCs will ultimately lead to better cancer treatments. Currently, accessible conventional therapeutic agents mainly eliminate the bulk tumor but do not eliminate CSCs. Therefore, the discovery and improvement of CSC-targeting therapeutic agents are necessary. Nanoparticles effectively inhibit multiple types of CSCs by targeting specific signaling pathways (Wnt/ß-catenin, Notch, transforming growth factor-ß, and hedgehog signaling) and/or specific markers (aldehyde dehydrogenases, CD44, CD90, and CD133) critically involved in CSC function and maintenance. In this review article, we summarized a number of findings to provide current information about their therapeutic potential of nanoparticles in various cancer cell types and CSCs. Keywords: ALDH, Wnt/ß-catenin, Hedgehog, Notch, TGF-ß signaling, CD44, CD133Hong ISJang GBLee HYNam JSDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Special Issue on diverse applications in Nano-Theranostics, Pp 251-260 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Hong IS Jang GB Lee HY Nam JS Targeting cancer stem cells by using the nanoparticles
description	In-Sun Hong,1,2,* Gyu-Beom Jang,1,2,* Hwa-Yong Lee,3 Jeong-Seok Nam1,2 1Laboratory of Tumor Suppressor, Lee Gil Ya Cancer and Diabetes Institute, 2Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, 3The Faculty of Liberal Arts, Jungwon University, Chungbuk, Republic of Korea *These authors contributed equally to this work Abstract: Cancer stem cells (CSCs) have been shown to be markedly resistant to conventional cancer treatments such as chemotherapy and radiation therapy. Therefore, therapeutic strategies that selectively target CSCs will ultimately lead to better cancer treatments. Currently, accessible conventional therapeutic agents mainly eliminate the bulk tumor but do not eliminate CSCs. Therefore, the discovery and improvement of CSC-targeting therapeutic agents are necessary. Nanoparticles effectively inhibit multiple types of CSCs by targeting specific signaling pathways (Wnt/ß-catenin, Notch, transforming growth factor-ß, and hedgehog signaling) and/or specific markers (aldehyde dehydrogenases, CD44, CD90, and CD133) critically involved in CSC function and maintenance. In this review article, we summarized a number of findings to provide current information about their therapeutic potential of nanoparticles in various cancer cell types and CSCs. Keywords: ALDH, Wnt/ß-catenin, Hedgehog, Notch, TGF-ß signaling, CD44, CD133
format	article
author	Hong IS Jang GB Lee HY Nam JS
author_facet	Hong IS Jang GB Lee HY Nam JS
author_sort	Hong IS
title	Targeting cancer stem cells by using the nanoparticles
title_short	Targeting cancer stem cells by using the nanoparticles
title_full	Targeting cancer stem cells by using the nanoparticles
title_fullStr	Targeting cancer stem cells by using the nanoparticles
title_full_unstemmed	Targeting cancer stem cells by using the nanoparticles
title_sort	targeting cancer stem cells by using the nanoparticles
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/a8c524c514144d518d06a9a607fb8b49
work_keys_str_mv	AT hongis targetingcancerstemcellsbyusingthenanoparticles AT janggb targetingcancerstemcellsbyusingthenanoparticles AT leehy targetingcancerstemcellsbyusingthenanoparticles AT namjs targetingcancerstemcellsbyusingthenanoparticles
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Targeting cancer stem cells by using the nanoparticles

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