Subjective approach to optimal cross-sectional design of biodegradable magnesium alloy stent undergoing heterogeneous corrosion

Existing biodegradable Magnesium Alloy Stents (MAS) have several drawbacks, such as high restenosis, hasty degradation, and bulky cross-section, that limit their widespread application in a current clinical practice. To find the optimum stent with the smallest possible cross-section and adequate sca...

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Autores principales:	Najmeh Zarei, Seyed Ahmad Anvar, Sevan Goenezen
Formato:	article
Lenguaje:	EN
Publicado:	CTU Central Library 2021
Materias:	coronary stent biodegradation magnesium pitting corrosion finite element Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/a8c65107099646099c99fd9a95a4a2e7
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spelling	oai:doaj.org-article:a8c65107099646099c99fd9a95a4a2e72021-11-18T13:55:36ZSubjective approach to optimal cross-sectional design of biodegradable magnesium alloy stent undergoing heterogeneous corrosion1210-27091805-236310.14311/AP.2021.61.0661https://doaj.org/article/a8c65107099646099c99fd9a95a4a2e72021-10-01T00:00:00Zhttps://ojs.cvut.cz/ojs/index.php/ap/article/view/7080https://doaj.org/toc/1210-2709https://doaj.org/toc/1805-2363Existing biodegradable Magnesium Alloy Stents (MAS) have several drawbacks, such as high restenosis, hasty degradation, and bulky cross-section, that limit their widespread application in a current clinical practice. To find the optimum stent with the smallest possible cross-section and adequate scaffolding ability, a 3D finite element model of 25 MAS stents of different cross-sectional dimensions were analysed while localized corrosion was underway. For the stent geometric design, a generic sine-wave ring of biodegradable magnesium alloy (AZ31) was selected. Previous studies have shown that the long-term performance of MAS was characterized by two key features: Stent Recoil Percent (SRP) and Stent Radial Stiffness (SRS). In this research, the variation with time of these two features during the corrosion phase was monitored for the 25 stents. To find the optimum profile design of the stent subjectively (without using optimization codes and with much less computational costs), radial recoil was limited to 27 % (corresponding to about 10 % probability of in-stent diameter stenosis after an almost complete degradation) and the stent with the highest radial stiffness was selected. The comparison of the recoil performance of 25 stents during the heterogeneous corrosion phase showed that four stents would satisfy the recoil criterion and among these four, the one having a width of 0.161 mm and a thickness of 0.110 mm, showed a 24 % – 49 % higher radial stiffness at the end of the corrosion phase. Accordingly, this stent, which also showed a 23.28 % mass loss, was selected as the optimum choice and it has a thinner cross-sectional profile than commercially available MAS, which leads to a greater deliverability and lower rates of restenosis.Najmeh ZareiSeyed Ahmad AnvarSevan GoenezenCTU Central Libraryarticlecoronary stentbiodegradationmagnesiumpitting corrosionfinite elementEngineering (General). Civil engineering (General)TA1-2040ENActa Polytechnica, Vol 61, Iss 5, Pp 661-671 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coronary stent biodegradation magnesium pitting corrosion finite element Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	coronary stent biodegradation magnesium pitting corrosion finite element Engineering (General). Civil engineering (General) TA1-2040 Najmeh Zarei Seyed Ahmad Anvar Sevan Goenezen Subjective approach to optimal cross-sectional design of biodegradable magnesium alloy stent undergoing heterogeneous corrosion
description	Existing biodegradable Magnesium Alloy Stents (MAS) have several drawbacks, such as high restenosis, hasty degradation, and bulky cross-section, that limit their widespread application in a current clinical practice. To find the optimum stent with the smallest possible cross-section and adequate scaffolding ability, a 3D finite element model of 25 MAS stents of different cross-sectional dimensions were analysed while localized corrosion was underway. For the stent geometric design, a generic sine-wave ring of biodegradable magnesium alloy (AZ31) was selected. Previous studies have shown that the long-term performance of MAS was characterized by two key features: Stent Recoil Percent (SRP) and Stent Radial Stiffness (SRS). In this research, the variation with time of these two features during the corrosion phase was monitored for the 25 stents. To find the optimum profile design of the stent subjectively (without using optimization codes and with much less computational costs), radial recoil was limited to 27 % (corresponding to about 10 % probability of in-stent diameter stenosis after an almost complete degradation) and the stent with the highest radial stiffness was selected. The comparison of the recoil performance of 25 stents during the heterogeneous corrosion phase showed that four stents would satisfy the recoil criterion and among these four, the one having a width of 0.161 mm and a thickness of 0.110 mm, showed a 24 % – 49 % higher radial stiffness at the end of the corrosion phase. Accordingly, this stent, which also showed a 23.28 % mass loss, was selected as the optimum choice and it has a thinner cross-sectional profile than commercially available MAS, which leads to a greater deliverability and lower rates of restenosis.
format	article
author	Najmeh Zarei Seyed Ahmad Anvar Sevan Goenezen
author_facet	Najmeh Zarei Seyed Ahmad Anvar Sevan Goenezen
author_sort	Najmeh Zarei
title	Subjective approach to optimal cross-sectional design of biodegradable magnesium alloy stent undergoing heterogeneous corrosion
title_short	Subjective approach to optimal cross-sectional design of biodegradable magnesium alloy stent undergoing heterogeneous corrosion
title_full	Subjective approach to optimal cross-sectional design of biodegradable magnesium alloy stent undergoing heterogeneous corrosion
title_fullStr	Subjective approach to optimal cross-sectional design of biodegradable magnesium alloy stent undergoing heterogeneous corrosion
title_full_unstemmed	Subjective approach to optimal cross-sectional design of biodegradable magnesium alloy stent undergoing heterogeneous corrosion
title_sort	subjective approach to optimal cross-sectional design of biodegradable magnesium alloy stent undergoing heterogeneous corrosion
publisher	CTU Central Library
publishDate	2021
url	https://doaj.org/article/a8c65107099646099c99fd9a95a4a2e7
work_keys_str_mv	AT najmehzarei subjectiveapproachtooptimalcrosssectionaldesignofbiodegradablemagnesiumalloystentundergoingheterogeneouscorrosion AT seyedahmadanvar subjectiveapproachtooptimalcrosssectionaldesignofbiodegradablemagnesiumalloystentundergoingheterogeneouscorrosion AT sevangoenezen subjectiveapproachtooptimalcrosssectionaldesignofbiodegradablemagnesiumalloystentundergoingheterogeneouscorrosion
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Subjective approach to optimal cross-sectional design of biodegradable magnesium alloy stent undergoing heterogeneous corrosion

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