Vitamin D supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression

Abstract Background In addition to the well-known role of vitamin D in calcium homeostasis and bone metabolism, vitamin D is important in the modulation of the immune system and inflammatory processes. Vitamin D deficiency is common in patients with systemic lupus erythematosus (SLE), possibly as a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rosalie Magro, Christian Saliba, Liberato Camilleri, Christian Scerri, Andrew A. Borg
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Vitamin D Systemic lupus erythematosus Fatigue Interferon Disease activity Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/a8c8e429ec294a3c8f52b60e7caa2b94
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a8c8e429ec294a3c8f52b60e7caa2b94
record_format	dspace
spelling	oai:doaj.org-article:a8c8e429ec294a3c8f52b60e7caa2b942021-12-05T12:17:35ZVitamin D supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression10.1186/s41927-021-00223-12520-1026https://doaj.org/article/a8c8e429ec294a3c8f52b60e7caa2b942021-12-01T00:00:00Zhttps://doi.org/10.1186/s41927-021-00223-1https://doaj.org/toc/2520-1026Abstract Background In addition to the well-known role of vitamin D in calcium homeostasis and bone metabolism, vitamin D is important in the modulation of the immune system and inflammatory processes. Vitamin D deficiency is common in patients with systemic lupus erythematosus (SLE), possibly as a result of sun avoidance. The aim of this prospective open-label study was to assess the effect of the treatment of vitamin D deficiency and insufficiency in SLE patients, particularly with regards to disease activity, fatigue and interferon signature gene expression. Methods 31 SLE patients, 13 with vitamin D deficiency and 18 with vitamin D insufficiency were treated with vitamin D3. They were supplemented with vitamin D3 8000 IU daily for 8 weeks if they were vitamin D deficient, or 8000 IU daily for 4 weeks if they were insufficient. This was followed by 2000 IU daily maintenance. They were assessed at baseline, after 6 and 12 months by means of an interview, filling in questionnaires and blood tests. The expression of 12 interferon signature genes in RNA extracted from whole blood was measured by using QuantiGene Plex technology. Results An improvement in disease activity measured by systemic lupus erythematosus disease activity index-2K (SLEDAI-2K; p = 0.028) and fatigue measured by fatigue severity scale (FSS; p = 0.071) at 12 months were noted. A significant decrease in anti-double stranded deoxyribonucleic acid (dsDNA) titre (p = 0.045) was also noted. The mean interferon signature gene expression score decreased from baseline to 6 months, however statistical significance was not achieved (p = 0.165). Conclusions Improved disease activity and fatigue have been noted when Vitamin D has been supplemented in vitamin D deficient/insufficient SLE patients. One possible mechanism could be the suppression of the interferon signature gene expression. Trial registration: The study was registered with the ISRCTN registry on 12/04/2021 (Trial ID: ISRCTN59058825).Rosalie MagroChristian SalibaLiberato CamilleriChristian ScerriAndrew A. BorgBMCarticleVitamin DSystemic lupus erythematosusFatigueInterferonDisease activityDiseases of the musculoskeletal systemRC925-935ENBMC Rheumatology, Vol 5, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vitamin D Systemic lupus erythematosus Fatigue Interferon Disease activity Diseases of the musculoskeletal system RC925-935
spellingShingle	Vitamin D Systemic lupus erythematosus Fatigue Interferon Disease activity Diseases of the musculoskeletal system RC925-935 Rosalie Magro Christian Saliba Liberato Camilleri Christian Scerri Andrew A. Borg Vitamin D supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression
description	Abstract Background In addition to the well-known role of vitamin D in calcium homeostasis and bone metabolism, vitamin D is important in the modulation of the immune system and inflammatory processes. Vitamin D deficiency is common in patients with systemic lupus erythematosus (SLE), possibly as a result of sun avoidance. The aim of this prospective open-label study was to assess the effect of the treatment of vitamin D deficiency and insufficiency in SLE patients, particularly with regards to disease activity, fatigue and interferon signature gene expression. Methods 31 SLE patients, 13 with vitamin D deficiency and 18 with vitamin D insufficiency were treated with vitamin D3. They were supplemented with vitamin D3 8000 IU daily for 8 weeks if they were vitamin D deficient, or 8000 IU daily for 4 weeks if they were insufficient. This was followed by 2000 IU daily maintenance. They were assessed at baseline, after 6 and 12 months by means of an interview, filling in questionnaires and blood tests. The expression of 12 interferon signature genes in RNA extracted from whole blood was measured by using QuantiGene Plex technology. Results An improvement in disease activity measured by systemic lupus erythematosus disease activity index-2K (SLEDAI-2K; p = 0.028) and fatigue measured by fatigue severity scale (FSS; p = 0.071) at 12 months were noted. A significant decrease in anti-double stranded deoxyribonucleic acid (dsDNA) titre (p = 0.045) was also noted. The mean interferon signature gene expression score decreased from baseline to 6 months, however statistical significance was not achieved (p = 0.165). Conclusions Improved disease activity and fatigue have been noted when Vitamin D has been supplemented in vitamin D deficient/insufficient SLE patients. One possible mechanism could be the suppression of the interferon signature gene expression. Trial registration: The study was registered with the ISRCTN registry on 12/04/2021 (Trial ID: ISRCTN59058825).
format	article
author	Rosalie Magro Christian Saliba Liberato Camilleri Christian Scerri Andrew A. Borg
author_facet	Rosalie Magro Christian Saliba Liberato Camilleri Christian Scerri Andrew A. Borg
author_sort	Rosalie Magro
title	Vitamin D supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression
title_short	Vitamin D supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression
title_full	Vitamin D supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression
title_fullStr	Vitamin D supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression
title_full_unstemmed	Vitamin D supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression
title_sort	vitamin d supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a8c8e429ec294a3c8f52b60e7caa2b94
work_keys_str_mv	AT rosaliemagro vitamindsupplementationinsystemiclupuserythematosusrelationshiptodiseaseactivityfatigueandtheinterferonsignaturegeneexpression AT christiansaliba vitamindsupplementationinsystemiclupuserythematosusrelationshiptodiseaseactivityfatigueandtheinterferonsignaturegeneexpression AT liberatocamilleri vitamindsupplementationinsystemiclupuserythematosusrelationshiptodiseaseactivityfatigueandtheinterferonsignaturegeneexpression AT christianscerri vitamindsupplementationinsystemiclupuserythematosusrelationshiptodiseaseactivityfatigueandtheinterferonsignaturegeneexpression AT andrewaborg vitamindsupplementationinsystemiclupuserythematosusrelationshiptodiseaseactivityfatigueandtheinterferonsignaturegeneexpression
_version_	1718372094071275520

Vitamin D supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression

Ejemplares similares