SARS-CoV-2 genomic surveillance in Rondônia, Brazilian Western Amazon

Abstract SARS-CoV-2 has spread rapidly around the world, with Brazil currently considered an epicenter of the pandemic. The Northern region has the second highest incidence coefficient, as well as the third highest mortality rate in the country. This study aimed to investigate information about the...

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Autores principales:	Luan Felipo Botelho-Souza, Felipe Souza Nogueira-Lima, Tárcio Peixoto Roca, Felipe Gomes Naveca, Alcione de Oliveria dos Santos, Adriana Cristina Salvador Maia, Cicileia Correia da Silva, Aline Linhares Ferreira de Melo Mendonça, Celina Aparecida Bertoni Lugtenburg, Camila Flávia Gomes Azzi, Juliana Loca Furtado Fontes, Suelen Cavalcante, Rita de Cássia Pontello Rampazzo, Caio Henrique Nemeth Santos, Alice Paula Di Sabatino Guimarães, Fernando Rodrigues Máximo, Juan Miguel Villalobos-Salcedo, Deusilene Souza Vieira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8ca82f53cbf4ece8e4ab7ebb1c7a612
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spelling	oai:doaj.org-article:a8ca82f53cbf4ece8e4ab7ebb1c7a6122021-12-02T14:11:32ZSARS-CoV-2 genomic surveillance in Rondônia, Brazilian Western Amazon10.1038/s41598-021-83203-22045-2322https://doaj.org/article/a8ca82f53cbf4ece8e4ab7ebb1c7a6122021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83203-2https://doaj.org/toc/2045-2322Abstract SARS-CoV-2 has spread rapidly around the world, with Brazil currently considered an epicenter of the pandemic. The Northern region has the second highest incidence coefficient, as well as the third highest mortality rate in the country. This study aimed to investigate information about the evolutionary history of epidemic spread and genetic aspects of strains isolated on the Western Amazon, in the State of Rondônia, Brazil. It was possible to detect a total of 22 mutations. Some of these alterations may possibly be related to effects on transmissibility, the fidelity of RNA replication, the ability of cancer patients to respond to infection, beyond a mutation that emerged after the introduction of SARS-CoV-2 in Rondônia. At least two events of introduction were detected, corresponding to the B.1 and B.1.1 European lineages. An introduction was observed possibly through Argentina, where strains originated that circulated in the Minas Gerais and Ceará Brazilian states, prior to Rondônia (B.1.), as well as through the Minas Gerais state and the Federal District, which gave rise to strains that spread to Rondônia, from the capital to more rural parts of the state (B.1.1.). The findings show the need to monitor the genetic epidemiology of COVID-19, in order to surveil the virus’s evolution, dispersion and diversity.Luan Felipo Botelho-SouzaFelipe Souza Nogueira-LimaTárcio Peixoto RocaFelipe Gomes NavecaAlcione de Oliveria dos SantosAdriana Cristina Salvador MaiaCicileia Correia da SilvaAline Linhares Ferreira de Melo MendonçaCelina Aparecida Bertoni LugtenburgCamila Flávia Gomes AzziJuliana Loca Furtado FontesSuelen CavalcanteRita de Cássia Pontello RampazzoCaio Henrique Nemeth SantosAlice Paula Di Sabatino GuimarãesFernando Rodrigues MáximoJuan Miguel Villalobos-SalcedoDeusilene Souza VieiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luan Felipo Botelho-Souza Felipe Souza Nogueira-Lima Tárcio Peixoto Roca Felipe Gomes Naveca Alcione de Oliveria dos Santos Adriana Cristina Salvador Maia Cicileia Correia da Silva Aline Linhares Ferreira de Melo Mendonça Celina Aparecida Bertoni Lugtenburg Camila Flávia Gomes Azzi Juliana Loca Furtado Fontes Suelen Cavalcante Rita de Cássia Pontello Rampazzo Caio Henrique Nemeth Santos Alice Paula Di Sabatino Guimarães Fernando Rodrigues Máximo Juan Miguel Villalobos-Salcedo Deusilene Souza Vieira SARS-CoV-2 genomic surveillance in Rondônia, Brazilian Western Amazon
description	Abstract SARS-CoV-2 has spread rapidly around the world, with Brazil currently considered an epicenter of the pandemic. The Northern region has the second highest incidence coefficient, as well as the third highest mortality rate in the country. This study aimed to investigate information about the evolutionary history of epidemic spread and genetic aspects of strains isolated on the Western Amazon, in the State of Rondônia, Brazil. It was possible to detect a total of 22 mutations. Some of these alterations may possibly be related to effects on transmissibility, the fidelity of RNA replication, the ability of cancer patients to respond to infection, beyond a mutation that emerged after the introduction of SARS-CoV-2 in Rondônia. At least two events of introduction were detected, corresponding to the B.1 and B.1.1 European lineages. An introduction was observed possibly through Argentina, where strains originated that circulated in the Minas Gerais and Ceará Brazilian states, prior to Rondônia (B.1.), as well as through the Minas Gerais state and the Federal District, which gave rise to strains that spread to Rondônia, from the capital to more rural parts of the state (B.1.1.). The findings show the need to monitor the genetic epidemiology of COVID-19, in order to surveil the virus’s evolution, dispersion and diversity.
format	article
author	Luan Felipo Botelho-Souza Felipe Souza Nogueira-Lima Tárcio Peixoto Roca Felipe Gomes Naveca Alcione de Oliveria dos Santos Adriana Cristina Salvador Maia Cicileia Correia da Silva Aline Linhares Ferreira de Melo Mendonça Celina Aparecida Bertoni Lugtenburg Camila Flávia Gomes Azzi Juliana Loca Furtado Fontes Suelen Cavalcante Rita de Cássia Pontello Rampazzo Caio Henrique Nemeth Santos Alice Paula Di Sabatino Guimarães Fernando Rodrigues Máximo Juan Miguel Villalobos-Salcedo Deusilene Souza Vieira
author_facet	Luan Felipo Botelho-Souza Felipe Souza Nogueira-Lima Tárcio Peixoto Roca Felipe Gomes Naveca Alcione de Oliveria dos Santos Adriana Cristina Salvador Maia Cicileia Correia da Silva Aline Linhares Ferreira de Melo Mendonça Celina Aparecida Bertoni Lugtenburg Camila Flávia Gomes Azzi Juliana Loca Furtado Fontes Suelen Cavalcante Rita de Cássia Pontello Rampazzo Caio Henrique Nemeth Santos Alice Paula Di Sabatino Guimarães Fernando Rodrigues Máximo Juan Miguel Villalobos-Salcedo Deusilene Souza Vieira
author_sort	Luan Felipo Botelho-Souza
title	SARS-CoV-2 genomic surveillance in Rondônia, Brazilian Western Amazon
title_short	SARS-CoV-2 genomic surveillance in Rondônia, Brazilian Western Amazon
title_full	SARS-CoV-2 genomic surveillance in Rondônia, Brazilian Western Amazon
title_fullStr	SARS-CoV-2 genomic surveillance in Rondônia, Brazilian Western Amazon
title_full_unstemmed	SARS-CoV-2 genomic surveillance in Rondônia, Brazilian Western Amazon
title_sort	sars-cov-2 genomic surveillance in rondônia, brazilian western amazon
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8ca82f53cbf4ece8e4ab7ebb1c7a612
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SARS-CoV-2 genomic surveillance in Rondônia, Brazilian Western Amazon

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