Cedar virus: a novel Henipavirus isolated from Australian bats.

The genus Henipavirus in the family Paramyxoviridae contains two viruses, Hendra virus (HeV) and Nipah virus (NiV) for which pteropid bats act as the main natural reservoir. Each virus also causes serious and commonly lethal infection of people as well as various species of domestic animals, however...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Glenn A Marsh, Carol de Jong, Jennifer A Barr, Mary Tachedjian, Craig Smith, Deborah Middleton, Meng Yu, Shawn Todd, Adam J Foord, Volker Haring, Jean Payne, Rachel Robinson, Ivano Broz, Gary Crameri, Hume E Field, Lin-Fa Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a8cc89afa9a34233ab1c79db12177a03
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a8cc89afa9a34233ab1c79db12177a03
record_format	dspace
spelling	oai:doaj.org-article:a8cc89afa9a34233ab1c79db12177a032021-11-18T06:04:07ZCedar virus: a novel Henipavirus isolated from Australian bats.1553-73661553-737410.1371/journal.ppat.1002836https://doaj.org/article/a8cc89afa9a34233ab1c79db12177a032012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22879820/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The genus Henipavirus in the family Paramyxoviridae contains two viruses, Hendra virus (HeV) and Nipah virus (NiV) for which pteropid bats act as the main natural reservoir. Each virus also causes serious and commonly lethal infection of people as well as various species of domestic animals, however little is known about the associated mechanisms of pathogenesis. Here, we report the isolation and characterization of a new paramyxovirus from pteropid bats, Cedar virus (CedPV), which shares significant features with the known henipaviruses. The genome size (18,162 nt) and organization of CedPV is very similar to that of HeV and NiV; its nucleocapsid protein displays antigenic cross-reactivity with henipaviruses; and it uses the same receptor molecule (ephrin-B2) for entry during infection. Preliminary challenge studies with CedPV in ferrets and guinea pigs, both susceptible to infection and disease with known henipaviruses, confirmed virus replication and production of neutralizing antibodies although clinical disease was not observed. In this context, it is interesting to note that the major genetic difference between CedPV and HeV or NiV lies within the coding strategy of the P gene, which is known to play an important role in evading the host innate immune system. Unlike HeV, NiV, and almost all known paramyxoviruses, the CedPV P gene lacks both RNA editing and also the coding capacity for the highly conserved V protein. Preliminary study indicated that CedPV infection of human cells induces a more robust IFN-β response than HeV.Glenn A MarshCarol de JongJennifer A BarrMary TachedjianCraig SmithDeborah MiddletonMeng YuShawn ToddAdam J FoordVolker HaringJean PayneRachel RobinsonIvano BrozGary CrameriHume E FieldLin-Fa WangPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 8, Iss 8, p e1002836 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Glenn A Marsh Carol de Jong Jennifer A Barr Mary Tachedjian Craig Smith Deborah Middleton Meng Yu Shawn Todd Adam J Foord Volker Haring Jean Payne Rachel Robinson Ivano Broz Gary Crameri Hume E Field Lin-Fa Wang Cedar virus: a novel Henipavirus isolated from Australian bats.
description	The genus Henipavirus in the family Paramyxoviridae contains two viruses, Hendra virus (HeV) and Nipah virus (NiV) for which pteropid bats act as the main natural reservoir. Each virus also causes serious and commonly lethal infection of people as well as various species of domestic animals, however little is known about the associated mechanisms of pathogenesis. Here, we report the isolation and characterization of a new paramyxovirus from pteropid bats, Cedar virus (CedPV), which shares significant features with the known henipaviruses. The genome size (18,162 nt) and organization of CedPV is very similar to that of HeV and NiV; its nucleocapsid protein displays antigenic cross-reactivity with henipaviruses; and it uses the same receptor molecule (ephrin-B2) for entry during infection. Preliminary challenge studies with CedPV in ferrets and guinea pigs, both susceptible to infection and disease with known henipaviruses, confirmed virus replication and production of neutralizing antibodies although clinical disease was not observed. In this context, it is interesting to note that the major genetic difference between CedPV and HeV or NiV lies within the coding strategy of the P gene, which is known to play an important role in evading the host innate immune system. Unlike HeV, NiV, and almost all known paramyxoviruses, the CedPV P gene lacks both RNA editing and also the coding capacity for the highly conserved V protein. Preliminary study indicated that CedPV infection of human cells induces a more robust IFN-β response than HeV.
format	article
author	Glenn A Marsh Carol de Jong Jennifer A Barr Mary Tachedjian Craig Smith Deborah Middleton Meng Yu Shawn Todd Adam J Foord Volker Haring Jean Payne Rachel Robinson Ivano Broz Gary Crameri Hume E Field Lin-Fa Wang
author_facet	Glenn A Marsh Carol de Jong Jennifer A Barr Mary Tachedjian Craig Smith Deborah Middleton Meng Yu Shawn Todd Adam J Foord Volker Haring Jean Payne Rachel Robinson Ivano Broz Gary Crameri Hume E Field Lin-Fa Wang
author_sort	Glenn A Marsh
title	Cedar virus: a novel Henipavirus isolated from Australian bats.
title_short	Cedar virus: a novel Henipavirus isolated from Australian bats.
title_full	Cedar virus: a novel Henipavirus isolated from Australian bats.
title_fullStr	Cedar virus: a novel Henipavirus isolated from Australian bats.
title_full_unstemmed	Cedar virus: a novel Henipavirus isolated from Australian bats.
title_sort	cedar virus: a novel henipavirus isolated from australian bats.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a8cc89afa9a34233ab1c79db12177a03
work_keys_str_mv	AT glennamarsh cedarvirusanovelhenipavirusisolatedfromaustralianbats AT caroldejong cedarvirusanovelhenipavirusisolatedfromaustralianbats AT jenniferabarr cedarvirusanovelhenipavirusisolatedfromaustralianbats AT marytachedjian cedarvirusanovelhenipavirusisolatedfromaustralianbats AT craigsmith cedarvirusanovelhenipavirusisolatedfromaustralianbats AT deborahmiddleton cedarvirusanovelhenipavirusisolatedfromaustralianbats AT mengyu cedarvirusanovelhenipavirusisolatedfromaustralianbats AT shawntodd cedarvirusanovelhenipavirusisolatedfromaustralianbats AT adamjfoord cedarvirusanovelhenipavirusisolatedfromaustralianbats AT volkerharing cedarvirusanovelhenipavirusisolatedfromaustralianbats AT jeanpayne cedarvirusanovelhenipavirusisolatedfromaustralianbats AT rachelrobinson cedarvirusanovelhenipavirusisolatedfromaustralianbats AT ivanobroz cedarvirusanovelhenipavirusisolatedfromaustralianbats AT garycrameri cedarvirusanovelhenipavirusisolatedfromaustralianbats AT humeefield cedarvirusanovelhenipavirusisolatedfromaustralianbats AT linfawang cedarvirusanovelhenipavirusisolatedfromaustralianbats
_version_	1718424625061298176

Cedar virus: a novel Henipavirus isolated from Australian bats.

Ejemplares similares