Simultaneous Quantification of Propylthiouracil and Its <i>N</i>-β-<span style="font-variant: small-caps">d</span> Glucuronide by HPLC-MS/MS: Application to a Metabolic Study
Propylthiouracil (PTU) is commonly prescribed for the management of hyperthyroidism and thyrotoxicosis. Although the exact mechanism of action is not fully understood, PTU is associated with hepatoxicity in pediatric population. Glucuronidation mediated by uridine 5′-diphospho-glucuronosyltransferas...
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| Main Authors: | , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
MDPI AG
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/a8d10f0df6d343ab9a5a1a043188ee4c |
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