ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy

Non alcoholic fatty liver disease (NAFLD) associates with an elevated risk of developing hepatocellular carcinoma (HCC). Here, the authors find that Nogo-B, an endoplasmic reticulum resident protein, is upregulated by lipid uptake and acts as an oncogene in NAFLD-associated HCC by promoting lipid dr...

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Autores principales:	Yuan Tian, Bin Yang, Weinan Qiu, Yajing Hao, Zhenxing Zhang, Bo Yang, Nan Li, Shuqun Cheng, Zhangjun Lin, Yao-cheng Rui, Otto K. W. Cheung, Weiqin Yang, William K. K. Wu, Yue-Sun Cheung, Paul B. S. Lai, Jianjun Luo, Joseph J. Y. Sung, Runsheng Chen, Hong-Yang Wang, Alfred S. L. Cheng, Pengyuan Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a8d1c1e18c374e28bc9f4c1c7dd4b98d
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spelling	oai:doaj.org-article:a8d1c1e18c374e28bc9f4c1c7dd4b98d2021-12-02T14:39:35ZER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy10.1038/s41467-019-11274-x2041-1723https://doaj.org/article/a8d1c1e18c374e28bc9f4c1c7dd4b98d2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11274-xhttps://doaj.org/toc/2041-1723Non alcoholic fatty liver disease (NAFLD) associates with an elevated risk of developing hepatocellular carcinoma (HCC). Here, the authors find that Nogo-B, an endoplasmic reticulum resident protein, is upregulated by lipid uptake and acts as an oncogene in NAFLD-associated HCC by promoting lipid droplet breakdown by lipophagy and triggering Hippo pathway dysregulationYuan TianBin YangWeinan QiuYajing HaoZhenxing ZhangBo YangNan LiShuqun ChengZhangjun LinYao-cheng RuiOtto K. W. CheungWeiqin YangWilliam K. K. WuYue-Sun CheungPaul B. S. LaiJianjun LuoJoseph J. Y. SungRunsheng ChenHong-Yang WangAlfred S. L. ChengPengyuan YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Tian Bin Yang Weinan Qiu Yajing Hao Zhenxing Zhang Bo Yang Nan Li Shuqun Cheng Zhangjun Lin Yao-cheng Rui Otto K. W. Cheung Weiqin Yang William K. K. Wu Yue-Sun Cheung Paul B. S. Lai Jianjun Luo Joseph J. Y. Sung Runsheng Chen Hong-Yang Wang Alfred S. L. Cheng Pengyuan Yang ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
description	Non alcoholic fatty liver disease (NAFLD) associates with an elevated risk of developing hepatocellular carcinoma (HCC). Here, the authors find that Nogo-B, an endoplasmic reticulum resident protein, is upregulated by lipid uptake and acts as an oncogene in NAFLD-associated HCC by promoting lipid droplet breakdown by lipophagy and triggering Hippo pathway dysregulation
format	article
author	Yuan Tian Bin Yang Weinan Qiu Yajing Hao Zhenxing Zhang Bo Yang Nan Li Shuqun Cheng Zhangjun Lin Yao-cheng Rui Otto K. W. Cheung Weiqin Yang William K. K. Wu Yue-Sun Cheung Paul B. S. Lai Jianjun Luo Joseph J. Y. Sung Runsheng Chen Hong-Yang Wang Alfred S. L. Cheng Pengyuan Yang
author_facet	Yuan Tian Bin Yang Weinan Qiu Yajing Hao Zhenxing Zhang Bo Yang Nan Li Shuqun Cheng Zhangjun Lin Yao-cheng Rui Otto K. W. Cheung Weiqin Yang William K. K. Wu Yue-Sun Cheung Paul B. S. Lai Jianjun Luo Joseph J. Y. Sung Runsheng Chen Hong-Yang Wang Alfred S. L. Cheng Pengyuan Yang
author_sort	Yuan Tian
title	ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
title_short	ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
title_full	ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
title_fullStr	ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
title_full_unstemmed	ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
title_sort	er-residential nogo-b accelerates nafld-associated hcc mediated by metabolic reprogramming of oxldl lipophagy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a8d1c1e18c374e28bc9f4c1c7dd4b98d
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ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy

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