Molecular programs of fibrotic change in aging human lung

Age is associated with increasing vulnerability to both acute and chronic lung diseases. Employing genomic analysis and live lung imaging, this study reveals a profile of increased cellular senescence, telomere shortening, and fibrosis-induced impaired alveolar function in the natural history of hum...

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Autores principales:	Seoyeon Lee, Mohammad Naimul Islam, Kaveh Boostanpour, Dvir Aran, Guangchun Jin, Stephanie Christenson, Michael A. Matthay, Walter L. Eckalbar, Daryle J. DePianto, Joseph R. Arron, Liam Magee, Sunita Bhattacharya, Rei Matsumoto, Masaru Kubota, Donna L. Farber, Jahar Bhattacharya, Paul J. Wolters, Mallar Bhattacharya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a8e19683da4c4b2a8b772edf8db594e5
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spelling	oai:doaj.org-article:a8e19683da4c4b2a8b772edf8db594e52021-11-08T11:12:01ZMolecular programs of fibrotic change in aging human lung10.1038/s41467-021-26603-22041-1723https://doaj.org/article/a8e19683da4c4b2a8b772edf8db594e52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26603-2https://doaj.org/toc/2041-1723Age is associated with increasing vulnerability to both acute and chronic lung diseases. Employing genomic analysis and live lung imaging, this study reveals a profile of increased cellular senescence, telomere shortening, and fibrosis-induced impaired alveolar function in the natural history of human lung aging.Seoyeon LeeMohammad Naimul IslamKaveh BoostanpourDvir AranGuangchun JinStephanie ChristensonMichael A. MatthayWalter L. EckalbarDaryle J. DePiantoJoseph R. ArronLiam MageeSunita BhattacharyaRei MatsumotoMasaru KubotaDonna L. FarberJahar BhattacharyaPaul J. WoltersMallar BhattacharyaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seoyeon Lee Mohammad Naimul Islam Kaveh Boostanpour Dvir Aran Guangchun Jin Stephanie Christenson Michael A. Matthay Walter L. Eckalbar Daryle J. DePianto Joseph R. Arron Liam Magee Sunita Bhattacharya Rei Matsumoto Masaru Kubota Donna L. Farber Jahar Bhattacharya Paul J. Wolters Mallar Bhattacharya Molecular programs of fibrotic change in aging human lung
description	Age is associated with increasing vulnerability to both acute and chronic lung diseases. Employing genomic analysis and live lung imaging, this study reveals a profile of increased cellular senescence, telomere shortening, and fibrosis-induced impaired alveolar function in the natural history of human lung aging.
format	article
author	Seoyeon Lee Mohammad Naimul Islam Kaveh Boostanpour Dvir Aran Guangchun Jin Stephanie Christenson Michael A. Matthay Walter L. Eckalbar Daryle J. DePianto Joseph R. Arron Liam Magee Sunita Bhattacharya Rei Matsumoto Masaru Kubota Donna L. Farber Jahar Bhattacharya Paul J. Wolters Mallar Bhattacharya
author_facet	Seoyeon Lee Mohammad Naimul Islam Kaveh Boostanpour Dvir Aran Guangchun Jin Stephanie Christenson Michael A. Matthay Walter L. Eckalbar Daryle J. DePianto Joseph R. Arron Liam Magee Sunita Bhattacharya Rei Matsumoto Masaru Kubota Donna L. Farber Jahar Bhattacharya Paul J. Wolters Mallar Bhattacharya
author_sort	Seoyeon Lee
title	Molecular programs of fibrotic change in aging human lung
title_short	Molecular programs of fibrotic change in aging human lung
title_full	Molecular programs of fibrotic change in aging human lung
title_fullStr	Molecular programs of fibrotic change in aging human lung
title_full_unstemmed	Molecular programs of fibrotic change in aging human lung
title_sort	molecular programs of fibrotic change in aging human lung
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8e19683da4c4b2a8b772edf8db594e5
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Molecular programs of fibrotic change in aging human lung

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