Early life experiences selectively mature learning and memory abilities
The mechanisms underlying the maturation of learning and memory abilities are poorly understood. Here, authors show that episodic learning produces persistent neuronal activation, BDNF-dependent increase in excitatory synapse markers (synaptophysin and PSD-95), and significant maturation of AMPA rec...
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Nature Portfolio
2020
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oai:doaj.org-article:a8e2e0d3d6fc4c4399d2a879420d353b2021-12-02T14:41:24ZEarly life experiences selectively mature learning and memory abilities10.1038/s41467-020-14461-32041-1723https://doaj.org/article/a8e2e0d3d6fc4c4399d2a879420d353b2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14461-3https://doaj.org/toc/2041-1723The mechanisms underlying the maturation of learning and memory abilities are poorly understood. Here, authors show that episodic learning produces persistent neuronal activation, BDNF-dependent increase in excitatory synapse markers (synaptophysin and PSD-95), and significant maturation of AMPA receptor synaptic responses in the hippocampus of infant rats and mice compared to juveniles and adults.Benjamin BessièresAlessio TravagliaTodd M. MoweryXinying ZhangCristina M. AlberiniNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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Science Q Benjamin Bessières Alessio Travaglia Todd M. Mowery Xinying Zhang Cristina M. Alberini Early life experiences selectively mature learning and memory abilities |
description |
The mechanisms underlying the maturation of learning and memory abilities are poorly understood. Here, authors show that episodic learning produces persistent neuronal activation, BDNF-dependent increase in excitatory synapse markers (synaptophysin and PSD-95), and significant maturation of AMPA receptor synaptic responses in the hippocampus of infant rats and mice compared to juveniles and adults. |
format |
article |
author |
Benjamin Bessières Alessio Travaglia Todd M. Mowery Xinying Zhang Cristina M. Alberini |
author_facet |
Benjamin Bessières Alessio Travaglia Todd M. Mowery Xinying Zhang Cristina M. Alberini |
author_sort |
Benjamin Bessières |
title |
Early life experiences selectively mature learning and memory abilities |
title_short |
Early life experiences selectively mature learning and memory abilities |
title_full |
Early life experiences selectively mature learning and memory abilities |
title_fullStr |
Early life experiences selectively mature learning and memory abilities |
title_full_unstemmed |
Early life experiences selectively mature learning and memory abilities |
title_sort |
early life experiences selectively mature learning and memory abilities |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/a8e2e0d3d6fc4c4399d2a879420d353b |
work_keys_str_mv |
AT benjaminbessieres earlylifeexperiencesselectivelymaturelearningandmemoryabilities AT alessiotravaglia earlylifeexperiencesselectivelymaturelearningandmemoryabilities AT toddmmowery earlylifeexperiencesselectivelymaturelearningandmemoryabilities AT xinyingzhang earlylifeexperiencesselectivelymaturelearningandmemoryabilities AT cristinamalberini earlylifeexperiencesselectivelymaturelearningandmemoryabilities |
_version_ |
1718389889044578304 |