Early life experiences selectively mature learning and memory abilities

The mechanisms underlying the maturation of learning and memory abilities are poorly understood. Here, authors show that episodic learning produces persistent neuronal activation, BDNF-dependent increase in excitatory synapse markers (synaptophysin and PSD-95), and significant maturation of AMPA rec...

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Autores principales: Benjamin Bessières, Alessio Travaglia, Todd M. Mowery, Xinying Zhang, Cristina M. Alberini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a8e2e0d3d6fc4c4399d2a879420d353b
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spelling oai:doaj.org-article:a8e2e0d3d6fc4c4399d2a879420d353b2021-12-02T14:41:24ZEarly life experiences selectively mature learning and memory abilities10.1038/s41467-020-14461-32041-1723https://doaj.org/article/a8e2e0d3d6fc4c4399d2a879420d353b2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14461-3https://doaj.org/toc/2041-1723The mechanisms underlying the maturation of learning and memory abilities are poorly understood. Here, authors show that episodic learning produces persistent neuronal activation, BDNF-dependent increase in excitatory synapse markers (synaptophysin and PSD-95), and significant maturation of AMPA receptor synaptic responses in the hippocampus of infant rats and mice compared to juveniles and adults.Benjamin BessièresAlessio TravagliaTodd M. MoweryXinying ZhangCristina M. AlberiniNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Benjamin Bessières
Alessio Travaglia
Todd M. Mowery
Xinying Zhang
Cristina M. Alberini
Early life experiences selectively mature learning and memory abilities
description The mechanisms underlying the maturation of learning and memory abilities are poorly understood. Here, authors show that episodic learning produces persistent neuronal activation, BDNF-dependent increase in excitatory synapse markers (synaptophysin and PSD-95), and significant maturation of AMPA receptor synaptic responses in the hippocampus of infant rats and mice compared to juveniles and adults.
format article
author Benjamin Bessières
Alessio Travaglia
Todd M. Mowery
Xinying Zhang
Cristina M. Alberini
author_facet Benjamin Bessières
Alessio Travaglia
Todd M. Mowery
Xinying Zhang
Cristina M. Alberini
author_sort Benjamin Bessières
title Early life experiences selectively mature learning and memory abilities
title_short Early life experiences selectively mature learning and memory abilities
title_full Early life experiences selectively mature learning and memory abilities
title_fullStr Early life experiences selectively mature learning and memory abilities
title_full_unstemmed Early life experiences selectively mature learning and memory abilities
title_sort early life experiences selectively mature learning and memory abilities
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/a8e2e0d3d6fc4c4399d2a879420d353b
work_keys_str_mv AT benjaminbessieres earlylifeexperiencesselectivelymaturelearningandmemoryabilities
AT alessiotravaglia earlylifeexperiencesselectivelymaturelearningandmemoryabilities
AT toddmmowery earlylifeexperiencesselectivelymaturelearningandmemoryabilities
AT xinyingzhang earlylifeexperiencesselectivelymaturelearningandmemoryabilities
AT cristinamalberini earlylifeexperiencesselectivelymaturelearningandmemoryabilities
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