DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer

Shen and Korm et al. investigate the role of dihydrolipoamide S-succinyltransferase (DLST), a tricarboxylic acid (TCA) cycle enzyme, in the metabolic heterogeneity of triple negative breast cancer (TNBC) cell lines. They show that either depletion or inhibition of DLST in the dependent cells leads t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ning Shen, Sovannarith Korm, Theodoros Karantanos, Dun Li, Xiaoyu Zhang, Eleni Ritou, Hanfei Xu, Andrew Lam, Justin English, Wei-Xing Zong, Ching-Ti Liu, Orian Shirihai, Hui Feng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a8e5c3aaebb34b0ca493310c2fcbbf13
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a8e5c3aaebb34b0ca493310c2fcbbf13
record_format	dspace
spelling	oai:doaj.org-article:a8e5c3aaebb34b0ca493310c2fcbbf132021-11-21T12:08:43ZDLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer10.1038/s42003-021-02805-82399-3642https://doaj.org/article/a8e5c3aaebb34b0ca493310c2fcbbf132021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02805-8https://doaj.org/toc/2399-3642Shen and Korm et al. investigate the role of dihydrolipoamide S-succinyltransferase (DLST), a tricarboxylic acid (TCA) cycle enzyme, in the metabolic heterogeneity of triple negative breast cancer (TNBC) cell lines. They show that either depletion or inhibition of DLST in the dependent cells leads to decreased invasion and metastasis in vitro and in vivo.Ning ShenSovannarith KormTheodoros KarantanosDun LiXiaoyu ZhangEleni RitouHanfei XuAndrew LamJustin EnglishWei-Xing ZongChing-Ti LiuOrian ShirihaiHui FengNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ning Shen Sovannarith Korm Theodoros Karantanos Dun Li Xiaoyu Zhang Eleni Ritou Hanfei Xu Andrew Lam Justin English Wei-Xing Zong Ching-Ti Liu Orian Shirihai Hui Feng DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer
description	Shen and Korm et al. investigate the role of dihydrolipoamide S-succinyltransferase (DLST), a tricarboxylic acid (TCA) cycle enzyme, in the metabolic heterogeneity of triple negative breast cancer (TNBC) cell lines. They show that either depletion or inhibition of DLST in the dependent cells leads to decreased invasion and metastasis in vitro and in vivo.
format	article
author	Ning Shen Sovannarith Korm Theodoros Karantanos Dun Li Xiaoyu Zhang Eleni Ritou Hanfei Xu Andrew Lam Justin English Wei-Xing Zong Ching-Ti Liu Orian Shirihai Hui Feng
author_facet	Ning Shen Sovannarith Korm Theodoros Karantanos Dun Li Xiaoyu Zhang Eleni Ritou Hanfei Xu Andrew Lam Justin English Wei-Xing Zong Ching-Ti Liu Orian Shirihai Hui Feng
author_sort	Ning Shen
title	DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer
title_short	DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer
title_full	DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer
title_fullStr	DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer
title_full_unstemmed	DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer
title_sort	dlst-dependence dictates metabolic heterogeneity in tca-cycle usage among triple-negative breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8e5c3aaebb34b0ca493310c2fcbbf13
work_keys_str_mv	AT ningshen dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer AT sovannarithkorm dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer AT theodoroskarantanos dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer AT dunli dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer AT xiaoyuzhang dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer AT eleniritou dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer AT hanfeixu dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer AT andrewlam dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer AT justinenglish dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer AT weixingzong dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer AT chingtiliu dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer AT orianshirihai dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer AT huifeng dlstdependencedictatesmetabolicheterogeneityintcacycleusageamongtriplenegativebreastcancer
_version_	1718419204665769984

DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer

Ejemplares similares