Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population

Abstract Immunoglobulin G (IgG) functionality can drastically change from anti- to proinflammatory by alterations in the IgG N-glycan patterns. Our previous studies have demonstrated that IgG N-glycans associated with the risk factors of dementia, such as aging, dyslipidemia, type 2 diabetes mellitu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaoyu Zhang, Hui Yuan, Jihui Lyu, Xiaoni Meng, Qiuyue Tian, Yuejin Li, Jie Zhang, Xizhu Xu, Jing Su, Haifeng Hou, Dong Li, Baoliang Sun, Wei Wang, Youxin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/a8e693e8a0ec4afabaff9909a3db5698
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a8e693e8a0ec4afabaff9909a3db5698
record_format	dspace
spelling	oai:doaj.org-article:a8e693e8a0ec4afabaff9909a3db56982021-12-02T14:41:07ZAssociation of dementia with immunoglobulin G N-glycans in a Chinese Han Population10.1038/s41514-021-00055-w2056-3973https://doaj.org/article/a8e693e8a0ec4afabaff9909a3db56982021-02-01T00:00:00Zhttps://doi.org/10.1038/s41514-021-00055-whttps://doaj.org/toc/2056-3973Abstract Immunoglobulin G (IgG) functionality can drastically change from anti- to proinflammatory by alterations in the IgG N-glycan patterns. Our previous studies have demonstrated that IgG N-glycans associated with the risk factors of dementia, such as aging, dyslipidemia, type 2 diabetes mellitus, hypertension, and ischemic stroke. Therefore, the aim is to investigate whether the effects of IgG N-glycan profiles on dementia exists in a Chinese Han population. A case–control study, including 81 patients with dementia, 81 age- and gender-matched controls with normal cognitive functioning (NC) and 108 non-matched controls with mild cognitive impairment (MCI) was performed. Plasma IgG N-glycans were separated by ultra-performance liquid chromatography. Fourteen glycan peaks reflecting decreased of sialylation and core fucosylation, and increased bisecting N-acetylglucosamine (GlcNAc) N-glycan structures were of statistically significant differences between dementia and NC groups after controlling for confounders (p < 0.05; q < 0.05). Similarly, the differences for these 14 initial glycans were statistically significant between AD and NC groups after adjusting for the effects of confounders (p < 0.05; q < 0.05). The area under the receiver operating curve (AUC) value of the model consisting of GP8, GP9, and GP14 was determined to distinguish dementia from NC group as 0.876 [95% confidence interval (CI): 0.815–0.923] and distinguish AD from NC group as 0.887 (95% CI: 0.819–0.936). Patients with dementia were of an elevated proinflammatory activity via the significant changes of IgG glycome. Therefore, IgG N-glycans might contribute to be potential novel biomarkers for the neurodegenerative process risk assessment of dementia.Xiaoyu ZhangHui YuanJihui LyuXiaoni MengQiuyue TianYuejin LiJie ZhangXizhu XuJing SuHaifeng HouDong LiBaoliang SunWei WangYouxin WangNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Xiaoyu Zhang Hui Yuan Jihui Lyu Xiaoni Meng Qiuyue Tian Yuejin Li Jie Zhang Xizhu Xu Jing Su Haifeng Hou Dong Li Baoliang Sun Wei Wang Youxin Wang Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population
description	Abstract Immunoglobulin G (IgG) functionality can drastically change from anti- to proinflammatory by alterations in the IgG N-glycan patterns. Our previous studies have demonstrated that IgG N-glycans associated with the risk factors of dementia, such as aging, dyslipidemia, type 2 diabetes mellitus, hypertension, and ischemic stroke. Therefore, the aim is to investigate whether the effects of IgG N-glycan profiles on dementia exists in a Chinese Han population. A case–control study, including 81 patients with dementia, 81 age- and gender-matched controls with normal cognitive functioning (NC) and 108 non-matched controls with mild cognitive impairment (MCI) was performed. Plasma IgG N-glycans were separated by ultra-performance liquid chromatography. Fourteen glycan peaks reflecting decreased of sialylation and core fucosylation, and increased bisecting N-acetylglucosamine (GlcNAc) N-glycan structures were of statistically significant differences between dementia and NC groups after controlling for confounders (p < 0.05; q < 0.05). Similarly, the differences for these 14 initial glycans were statistically significant between AD and NC groups after adjusting for the effects of confounders (p < 0.05; q < 0.05). The area under the receiver operating curve (AUC) value of the model consisting of GP8, GP9, and GP14 was determined to distinguish dementia from NC group as 0.876 [95% confidence interval (CI): 0.815–0.923] and distinguish AD from NC group as 0.887 (95% CI: 0.819–0.936). Patients with dementia were of an elevated proinflammatory activity via the significant changes of IgG glycome. Therefore, IgG N-glycans might contribute to be potential novel biomarkers for the neurodegenerative process risk assessment of dementia.
format	article
author	Xiaoyu Zhang Hui Yuan Jihui Lyu Xiaoni Meng Qiuyue Tian Yuejin Li Jie Zhang Xizhu Xu Jing Su Haifeng Hou Dong Li Baoliang Sun Wei Wang Youxin Wang
author_facet	Xiaoyu Zhang Hui Yuan Jihui Lyu Xiaoni Meng Qiuyue Tian Yuejin Li Jie Zhang Xizhu Xu Jing Su Haifeng Hou Dong Li Baoliang Sun Wei Wang Youxin Wang
author_sort	Xiaoyu Zhang
title	Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population
title_short	Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population
title_full	Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population
title_fullStr	Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population
title_full_unstemmed	Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population
title_sort	association of dementia with immunoglobulin g n-glycans in a chinese han population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8e693e8a0ec4afabaff9909a3db5698
work_keys_str_mv	AT xiaoyuzhang associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT huiyuan associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT jihuilyu associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT xiaonimeng associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT qiuyuetian associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT yuejinli associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT jiezhang associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT xizhuxu associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT jingsu associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT haifenghou associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT dongli associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT baoliangsun associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT weiwang associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation AT youxinwang associationofdementiawithimmunoglobulingnglycansinachinesehanpopulation
_version_	1718390010999209984

Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population

Ejemplares similares