The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster.

Wolbachia are vertically transmitted, obligatory intracellular bacteria that infect a great number of species of arthropods and nematodes. In insects, they are mainly known for disrupting the reproductive biology of their hosts in order to increase their transmission through the female germline. In...

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Autores principales:	Luís Teixeira, Alvaro Ferreira, Michael Ashburner
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a8e708bba213499f8fd208882dd819b5
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spelling	oai:doaj.org-article:a8e708bba213499f8fd208882dd819b52021-11-25T05:33:51ZThe bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster.1544-91731545-788510.1371/journal.pbio.1000002https://doaj.org/article/a8e708bba213499f8fd208882dd819b52008-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19222304/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Wolbachia are vertically transmitted, obligatory intracellular bacteria that infect a great number of species of arthropods and nematodes. In insects, they are mainly known for disrupting the reproductive biology of their hosts in order to increase their transmission through the female germline. In Drosophila melanogaster, however, a strong and consistent effect of Wolbachia infection has not been found. Here we report that a bacterial infection renders D. melanogaster more resistant to Drosophila C virus, reducing the load of viruses in infected flies. We identify these resistance-inducing bacteria as Wolbachia. Furthermore, we show that Wolbachia also increases resistance of Drosophila to two other RNA virus infections (Nora virus and Flock House virus) but not to a DNA virus infection (Insect Iridescent Virus 6). These results identify a new major factor regulating D. melanogaster resistance to infection by RNA viruses and contribute to the idea that the response of a host to a particular pathogen also depends on its interactions with other microorganisms. This is also, to our knowledge, the first report of a strong beneficial effect of Wolbachia infection in D. melanogaster. The induced resistance to natural viral pathogens may explain Wolbachia prevalence in natural populations and represents a novel Wolbachia-host interaction.Luís TeixeiraAlvaro FerreiraMichael AshburnerPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 6, Iss 12, p e2 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Luís Teixeira Alvaro Ferreira Michael Ashburner The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster.
description	Wolbachia are vertically transmitted, obligatory intracellular bacteria that infect a great number of species of arthropods and nematodes. In insects, they are mainly known for disrupting the reproductive biology of their hosts in order to increase their transmission through the female germline. In Drosophila melanogaster, however, a strong and consistent effect of Wolbachia infection has not been found. Here we report that a bacterial infection renders D. melanogaster more resistant to Drosophila C virus, reducing the load of viruses in infected flies. We identify these resistance-inducing bacteria as Wolbachia. Furthermore, we show that Wolbachia also increases resistance of Drosophila to two other RNA virus infections (Nora virus and Flock House virus) but not to a DNA virus infection (Insect Iridescent Virus 6). These results identify a new major factor regulating D. melanogaster resistance to infection by RNA viruses and contribute to the idea that the response of a host to a particular pathogen also depends on its interactions with other microorganisms. This is also, to our knowledge, the first report of a strong beneficial effect of Wolbachia infection in D. melanogaster. The induced resistance to natural viral pathogens may explain Wolbachia prevalence in natural populations and represents a novel Wolbachia-host interaction.
format	article
author	Luís Teixeira Alvaro Ferreira Michael Ashburner
author_facet	Luís Teixeira Alvaro Ferreira Michael Ashburner
author_sort	Luís Teixeira
title	The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster.
title_short	The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster.
title_full	The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster.
title_fullStr	The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster.
title_full_unstemmed	The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster.
title_sort	bacterial symbiont wolbachia induces resistance to rna viral infections in drosophila melanogaster.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/a8e708bba213499f8fd208882dd819b5
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The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster.

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