Uric acid as a prognostic factor and critical marker of COVID-19

Abstract The purpose of this study is to explore whether uric acid (UA) can independently act as a prognostic factor and critical marker of the 2019 novel corona virus disease (COVID-19). A multicenter, retrospective, and observational study including 540 patients with confirmed COVID-19 was carried...

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Autores principales:	Gang Li, Xia Wu, Chen-liang Zhou, Ye-ming Wang, Bin Song, Xiao-bin Cheng, Qiu-fen Dong, Liu-lin Wang, Sha-sha You, Yuan-ming Ba
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8e8859d800d4fcea4e7072829e594b2
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spelling	oai:doaj.org-article:a8e8859d800d4fcea4e7072829e594b22021-12-02T18:03:06ZUric acid as a prognostic factor and critical marker of COVID-1910.1038/s41598-021-96983-42045-2322https://doaj.org/article/a8e8859d800d4fcea4e7072829e594b22021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96983-4https://doaj.org/toc/2045-2322Abstract The purpose of this study is to explore whether uric acid (UA) can independently act as a prognostic factor and critical marker of the 2019 novel corona virus disease (COVID-19). A multicenter, retrospective, and observational study including 540 patients with confirmed COVID-19 was carried out at four designated hospitals in Wuhan. Demographic, clinical, laboratory data were collected and analyzed. The primary end point was in-hospital death of patients with COVID-19. The concentration of admission UA (adUA) and the lowest concentration of uric acid during hospitalization (lowUA) in the dead patients were significantly lower than those in the survivors. Multivariate logistic regression analysis showed the concentration of lowUA (OR 0.986, 95% CI 0.980–0.992, p < 0.001) was able to independently predict the risk of in-hospital death. The mean survival time in the low-level group of lowUA was significantly lower than other groups. When lowUA was ≤ 166 µmol/L, the sensitivity and specificity in predicting hospital short-term mortality were 76.9%, (95% CI 68.5–85.1%) and 74.9% (95% CI 70.3–78.9%). This retrospective study determined that the lowest concentration of UA during hospitalization can be used as a prognostic indicator and a marker of disease severity in severe patients with COVID-19.Gang LiXia WuChen-liang ZhouYe-ming WangBin SongXiao-bin ChengQiu-fen DongLiu-lin WangSha-sha YouYuan-ming BaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gang Li Xia Wu Chen-liang Zhou Ye-ming Wang Bin Song Xiao-bin Cheng Qiu-fen Dong Liu-lin Wang Sha-sha You Yuan-ming Ba Uric acid as a prognostic factor and critical marker of COVID-19
description	Abstract The purpose of this study is to explore whether uric acid (UA) can independently act as a prognostic factor and critical marker of the 2019 novel corona virus disease (COVID-19). A multicenter, retrospective, and observational study including 540 patients with confirmed COVID-19 was carried out at four designated hospitals in Wuhan. Demographic, clinical, laboratory data were collected and analyzed. The primary end point was in-hospital death of patients with COVID-19. The concentration of admission UA (adUA) and the lowest concentration of uric acid during hospitalization (lowUA) in the dead patients were significantly lower than those in the survivors. Multivariate logistic regression analysis showed the concentration of lowUA (OR 0.986, 95% CI 0.980–0.992, p < 0.001) was able to independently predict the risk of in-hospital death. The mean survival time in the low-level group of lowUA was significantly lower than other groups. When lowUA was ≤ 166 µmol/L, the sensitivity and specificity in predicting hospital short-term mortality were 76.9%, (95% CI 68.5–85.1%) and 74.9% (95% CI 70.3–78.9%). This retrospective study determined that the lowest concentration of UA during hospitalization can be used as a prognostic indicator and a marker of disease severity in severe patients with COVID-19.
format	article
author	Gang Li Xia Wu Chen-liang Zhou Ye-ming Wang Bin Song Xiao-bin Cheng Qiu-fen Dong Liu-lin Wang Sha-sha You Yuan-ming Ba
author_facet	Gang Li Xia Wu Chen-liang Zhou Ye-ming Wang Bin Song Xiao-bin Cheng Qiu-fen Dong Liu-lin Wang Sha-sha You Yuan-ming Ba
author_sort	Gang Li
title	Uric acid as a prognostic factor and critical marker of COVID-19
title_short	Uric acid as a prognostic factor and critical marker of COVID-19
title_full	Uric acid as a prognostic factor and critical marker of COVID-19
title_fullStr	Uric acid as a prognostic factor and critical marker of COVID-19
title_full_unstemmed	Uric acid as a prognostic factor and critical marker of COVID-19
title_sort	uric acid as a prognostic factor and critical marker of covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8e8859d800d4fcea4e7072829e594b2
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Uric acid as a prognostic factor and critical marker of COVID-19

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