Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging

Abstract The progressive increase of the aged population worldwide mandates new strategies to ensure sustained health and well-being with age. The development of better and/or new vaccines against pathogens that affect older adults is one pivotal intervention in approaching this goal. However, the f...

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Autores principales:	Giuseppe Del Giudice, Jörg J. Goronzy, Beatrix Grubeck-Loebenstein, Paul-Henri Lambert, Tomas Mrkvan, Jeffrey J. Stoddard, T. Mark Doherty
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/a8ee1fc6f7b64f2390b32b767db0e7f4
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spelling	oai:doaj.org-article:a8ee1fc6f7b64f2390b32b767db0e7f42021-12-02T13:41:45ZFighting against a protean enemy: immunosenescence, vaccines, and healthy aging10.1038/s41514-017-0020-02056-3973https://doaj.org/article/a8ee1fc6f7b64f2390b32b767db0e7f42017-12-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0020-0https://doaj.org/toc/2056-3973Abstract The progressive increase of the aged population worldwide mandates new strategies to ensure sustained health and well-being with age. The development of better and/or new vaccines against pathogens that affect older adults is one pivotal intervention in approaching this goal. However, the functional decline of various physiological systems, including the immune system, requires novel approaches to counteract immunosenescence. Although important progress has been made in understanding the mechanisms underlying the age-related decline of the immune response to infections and vaccinations, knowledge gaps remain, both in the areas of basic and translational research. In particular, it will be important to better understand how environmental factors, such as diet, physical activity, co-morbidities, and pharmacological treatments, delay or contribute to the decline of the capability of the aging immune system to appropriately respond to infectious diseases and vaccination. Recent findings suggest that successful approaches specifically targeted to the older population can be developed, such as the high-dose and adjuvanted vaccines against seasonal influenza, the adjuvanted subunit vaccine against herpes zoster, as well as experimental interventions with immune-potentiators or immunostimulants. Learning from these first successes may pave the way to developing novel and improved vaccines for the older adults and immunocompromised. With an integrated, holistic vaccination strategy, society will offer the opportunity for an improved quality of life to the segment of the population that is going to increase most significantly in numbers and proportion over future decades.Giuseppe Del GiudiceJörg J. GoronzyBeatrix Grubeck-LoebensteinPaul-Henri LambertTomas MrkvanJeffrey J. StoddardT. Mark DohertyNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 4, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Giuseppe Del Giudice Jörg J. Goronzy Beatrix Grubeck-Loebenstein Paul-Henri Lambert Tomas Mrkvan Jeffrey J. Stoddard T. Mark Doherty Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging
description	Abstract The progressive increase of the aged population worldwide mandates new strategies to ensure sustained health and well-being with age. The development of better and/or new vaccines against pathogens that affect older adults is one pivotal intervention in approaching this goal. However, the functional decline of various physiological systems, including the immune system, requires novel approaches to counteract immunosenescence. Although important progress has been made in understanding the mechanisms underlying the age-related decline of the immune response to infections and vaccinations, knowledge gaps remain, both in the areas of basic and translational research. In particular, it will be important to better understand how environmental factors, such as diet, physical activity, co-morbidities, and pharmacological treatments, delay or contribute to the decline of the capability of the aging immune system to appropriately respond to infectious diseases and vaccination. Recent findings suggest that successful approaches specifically targeted to the older population can be developed, such as the high-dose and adjuvanted vaccines against seasonal influenza, the adjuvanted subunit vaccine against herpes zoster, as well as experimental interventions with immune-potentiators or immunostimulants. Learning from these first successes may pave the way to developing novel and improved vaccines for the older adults and immunocompromised. With an integrated, holistic vaccination strategy, society will offer the opportunity for an improved quality of life to the segment of the population that is going to increase most significantly in numbers and proportion over future decades.
format	article
author	Giuseppe Del Giudice Jörg J. Goronzy Beatrix Grubeck-Loebenstein Paul-Henri Lambert Tomas Mrkvan Jeffrey J. Stoddard T. Mark Doherty
author_facet	Giuseppe Del Giudice Jörg J. Goronzy Beatrix Grubeck-Loebenstein Paul-Henri Lambert Tomas Mrkvan Jeffrey J. Stoddard T. Mark Doherty
author_sort	Giuseppe Del Giudice
title	Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging
title_short	Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging
title_full	Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging
title_fullStr	Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging
title_full_unstemmed	Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging
title_sort	fighting against a protean enemy: immunosenescence, vaccines, and healthy aging
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a8ee1fc6f7b64f2390b32b767db0e7f4
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Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging

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