Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1

Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1

Glucocorticoid receptor (GR) agonists - used in the treatment of solid malignant tumors to reduce inflammation - could potentially affect the anti-tumor activity of chemotherapy. Here, the authors identify a mechanism of cisplatin resistance observed with GR agonist treatment, and show the binding a...

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Autores principales: Chaoyun Pan, JiHoon Kang, Jung Seok Hwang, Jie Li, Austin C. Boese, Xu Wang, Likun Yang, Titus J. Boggon, Georgia Z. Chen, Nabil F. Saba, Dong M. Shin, Kelly R. Magliocca, Lingtao Jin, Sumin Kang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a8ee4777304348e7a36af27f053dd05c
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Sumario:Glucocorticoid receptor (GR) agonists - used in the treatment of solid malignant tumors to reduce inflammation - could potentially affect the anti-tumor activity of chemotherapy. Here, the authors identify a mechanism of cisplatin resistance observed with GR agonist treatment, and show the binding and activation of GR by cisplatin, which leads to MAST1 activation and subsequent MAPK re-activation.

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