Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1

Glucocorticoid receptor (GR) agonists - used in the treatment of solid malignant tumors to reduce inflammation - could potentially affect the anti-tumor activity of chemotherapy. Here, the authors identify a mechanism of cisplatin resistance observed with GR agonist treatment, and show the binding a...

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Autores principales:	Chaoyun Pan, JiHoon Kang, Jung Seok Hwang, Jie Li, Austin C. Boese, Xu Wang, Likun Yang, Titus J. Boggon, Georgia Z. Chen, Nabil F. Saba, Dong M. Shin, Kelly R. Magliocca, Lingtao Jin, Sumin Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a8ee4777304348e7a36af27f053dd05c
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spelling	oai:doaj.org-article:a8ee4777304348e7a36af27f053dd05c2021-12-02T18:00:08ZCisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST110.1038/s41467-021-24845-82041-1723https://doaj.org/article/a8ee4777304348e7a36af27f053dd05c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24845-8https://doaj.org/toc/2041-1723Glucocorticoid receptor (GR) agonists - used in the treatment of solid malignant tumors to reduce inflammation - could potentially affect the anti-tumor activity of chemotherapy. Here, the authors identify a mechanism of cisplatin resistance observed with GR agonist treatment, and show the binding and activation of GR by cisplatin, which leads to MAST1 activation and subsequent MAPK re-activation.Chaoyun PanJiHoon KangJung Seok HwangJie LiAustin C. BoeseXu WangLikun YangTitus J. BoggonGeorgia Z. ChenNabil F. SabaDong M. ShinKelly R. MaglioccaLingtao JinSumin KangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chaoyun Pan JiHoon Kang Jung Seok Hwang Jie Li Austin C. Boese Xu Wang Likun Yang Titus J. Boggon Georgia Z. Chen Nabil F. Saba Dong M. Shin Kelly R. Magliocca Lingtao Jin Sumin Kang Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1
description	Glucocorticoid receptor (GR) agonists - used in the treatment of solid malignant tumors to reduce inflammation - could potentially affect the anti-tumor activity of chemotherapy. Here, the authors identify a mechanism of cisplatin resistance observed with GR agonist treatment, and show the binding and activation of GR by cisplatin, which leads to MAST1 activation and subsequent MAPK re-activation.
format	article
author	Chaoyun Pan JiHoon Kang Jung Seok Hwang Jie Li Austin C. Boese Xu Wang Likun Yang Titus J. Boggon Georgia Z. Chen Nabil F. Saba Dong M. Shin Kelly R. Magliocca Lingtao Jin Sumin Kang
author_facet	Chaoyun Pan JiHoon Kang Jung Seok Hwang Jie Li Austin C. Boese Xu Wang Likun Yang Titus J. Boggon Georgia Z. Chen Nabil F. Saba Dong M. Shin Kelly R. Magliocca Lingtao Jin Sumin Kang
author_sort	Chaoyun Pan
title	Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1
title_short	Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1
title_full	Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1
title_fullStr	Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1
title_full_unstemmed	Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1
title_sort	cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via mast1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8ee4777304348e7a36af27f053dd05c
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Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1

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