Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes

Li et al. design and synthesize fluorescently labeled molecular tweezers to explore their internalization, intracellular localization, and mechanism of endocytosis in brain cells including neurons and astrocytes. The authors find that MTs are internalized in neurons and astrocytes, at least partiall...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zizheng Li, Ibrar Siddique, Inesa Hadrović, Abbna Kirupakaran, Jiwen Li, Ye Zhang, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a8efc1bcc1c2445089da253cba6fbb65
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a8efc1bcc1c2445089da253cba6fbb65
record_format	dspace
spelling	oai:doaj.org-article:a8efc1bcc1c2445089da253cba6fbb652021-12-02T18:02:14ZLysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes10.1038/s42003-021-02603-22399-3642https://doaj.org/article/a8efc1bcc1c2445089da253cba6fbb652021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02603-2https://doaj.org/toc/2399-3642Li et al. design and synthesize fluorescently labeled molecular tweezers to explore their internalization, intracellular localization, and mechanism of endocytosis in brain cells including neurons and astrocytes. The authors find that MTs are internalized in neurons and astrocytes, at least partially through dynamin-dependent endocytosis, and concentrate rapidly in acidic compartments, primarily lysosomes.Zizheng LiIbrar SiddiqueInesa HadrovićAbbna KirupakaranJiwen LiYe ZhangFrank-Gerrit KlärnerThomas SchraderGal BitanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Zizheng Li Ibrar Siddique Inesa Hadrović Abbna Kirupakaran Jiwen Li Ye Zhang Frank-Gerrit Klärner Thomas Schrader Gal Bitan Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
description	Li et al. design and synthesize fluorescently labeled molecular tweezers to explore their internalization, intracellular localization, and mechanism of endocytosis in brain cells including neurons and astrocytes. The authors find that MTs are internalized in neurons and astrocytes, at least partially through dynamin-dependent endocytosis, and concentrate rapidly in acidic compartments, primarily lysosomes.
format	article
author	Zizheng Li Ibrar Siddique Inesa Hadrović Abbna Kirupakaran Jiwen Li Ye Zhang Frank-Gerrit Klärner Thomas Schrader Gal Bitan
author_facet	Zizheng Li Ibrar Siddique Inesa Hadrović Abbna Kirupakaran Jiwen Li Ye Zhang Frank-Gerrit Klärner Thomas Schrader Gal Bitan
author_sort	Zizheng Li
title	Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
title_short	Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
title_full	Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
title_fullStr	Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
title_full_unstemmed	Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
title_sort	lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8efc1bcc1c2445089da253cba6fbb65
work_keys_str_mv	AT zizhengli lysineselectivemoleculartweezersarecellpenetrantandconcentrateinlysosomes AT ibrarsiddique lysineselectivemoleculartweezersarecellpenetrantandconcentrateinlysosomes AT inesahadrovic lysineselectivemoleculartweezersarecellpenetrantandconcentrateinlysosomes AT abbnakirupakaran lysineselectivemoleculartweezersarecellpenetrantandconcentrateinlysosomes AT jiwenli lysineselectivemoleculartweezersarecellpenetrantandconcentrateinlysosomes AT yezhang lysineselectivemoleculartweezersarecellpenetrantandconcentrateinlysosomes AT frankgerritklarner lysineselectivemoleculartweezersarecellpenetrantandconcentrateinlysosomes AT thomasschrader lysineselectivemoleculartweezersarecellpenetrantandconcentrateinlysosomes AT galbitan lysineselectivemoleculartweezersarecellpenetrantandconcentrateinlysosomes
_version_	1718378947015606272

Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes

Ejemplares similares