Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes

Li et al. design and synthesize fluorescently labeled molecular tweezers to explore their internalization, intracellular localization, and mechanism of endocytosis in brain cells including neurons and astrocytes. The authors find that MTs are internalized in neurons and astrocytes, at least partiall...

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Main Authors:	Zizheng Li, Ibrar Siddique, Inesa Hadrović, Abbna Kirupakaran, Jiwen Li, Ye Zhang, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/a8efc1bcc1c2445089da253cba6fbb65
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spelling	oai:doaj.org-article:a8efc1bcc1c2445089da253cba6fbb652021-12-02T18:02:14ZLysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes10.1038/s42003-021-02603-22399-3642https://doaj.org/article/a8efc1bcc1c2445089da253cba6fbb652021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02603-2https://doaj.org/toc/2399-3642Li et al. design and synthesize fluorescently labeled molecular tweezers to explore their internalization, intracellular localization, and mechanism of endocytosis in brain cells including neurons and astrocytes. The authors find that MTs are internalized in neurons and astrocytes, at least partially through dynamin-dependent endocytosis, and concentrate rapidly in acidic compartments, primarily lysosomes.Zizheng LiIbrar SiddiqueInesa HadrovićAbbna KirupakaranJiwen LiYe ZhangFrank-Gerrit KlärnerThomas SchraderGal BitanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Zizheng Li Ibrar Siddique Inesa Hadrović Abbna Kirupakaran Jiwen Li Ye Zhang Frank-Gerrit Klärner Thomas Schrader Gal Bitan Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
description	Li et al. design and synthesize fluorescently labeled molecular tweezers to explore their internalization, intracellular localization, and mechanism of endocytosis in brain cells including neurons and astrocytes. The authors find that MTs are internalized in neurons and astrocytes, at least partially through dynamin-dependent endocytosis, and concentrate rapidly in acidic compartments, primarily lysosomes.
format	article
author	Zizheng Li Ibrar Siddique Inesa Hadrović Abbna Kirupakaran Jiwen Li Ye Zhang Frank-Gerrit Klärner Thomas Schrader Gal Bitan
author_facet	Zizheng Li Ibrar Siddique Inesa Hadrović Abbna Kirupakaran Jiwen Li Ye Zhang Frank-Gerrit Klärner Thomas Schrader Gal Bitan
author_sort	Zizheng Li
title	Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
title_short	Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
title_full	Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
title_fullStr	Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
title_full_unstemmed	Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
title_sort	lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8efc1bcc1c2445089da253cba6fbb65
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Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes

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