HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada

Abstract Men who have sex with men (MSM) are disproportionately affected by anal cancer, predominantly caused by high-risk (HR) human papillomavirus (HPV) infection. Currently, the nonavalent HPV vaccine provides coverage against nine HPV genotypes, including seven HR-HPV genotypes. Here, we charact...

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Autores principales:	Yoojin Choi, Mona Loutfy, Robert S. Remis, Juan Liu, Anuradha Rebbapragada, Sanja Huibner, Jason Brunetta, Graham Smith, Tatjana Reko, Roberta Halpenny, Rupert Kaul, Troy Grennan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a8f2f8fba1bc486fa57b7c682b8e1f0b
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spelling	oai:doaj.org-article:a8f2f8fba1bc486fa57b7c682b8e1f0b2021-12-02T15:54:13ZHPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada10.1038/s41598-021-84079-y2045-2322https://doaj.org/article/a8f2f8fba1bc486fa57b7c682b8e1f0b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84079-yhttps://doaj.org/toc/2045-2322Abstract Men who have sex with men (MSM) are disproportionately affected by anal cancer, predominantly caused by high-risk (HR) human papillomavirus (HPV) infection. Currently, the nonavalent HPV vaccine provides coverage against nine HPV genotypes, including seven HR-HPV genotypes. Here, we characterize anal HR-HPV genotype distribution and associated risk factors in MSM from Toronto, Canada recruited between September 2010 and June 2012. Wilcoxon–Mann–Whitney test was used for continuous variables, Chi-square test was performed for categorical variables, and a multivariable model using logistic regression was created to assess for correlates of anal HR-HPV infection. A total of 442 MSM were recruited, with a median age of 45 (IQR 38–50) and an overall HPV prevalence of 82%. The prevalence of any HR-HPV infection was 65.3% and 50.7% in the HIV-positive and HIV-negative MSM, respectively. No participant tested positive for all genotypes covered by the nonavalent vaccine. HIV status (aOR 1.806; 95% CI 1.159–2.816), smoking (aOR 2.176; 95% CI 1.285–3.685) and the number of lifetime sexual partners (aOR 2.466; 95% CI 1.092–5.567) were independent risk factors for anal HR-HPV infection. Our findings will be useful to inform HPV vaccine rollout and HPV prevention strategies in Canadian MSM.Yoojin ChoiMona LoutfyRobert S. RemisJuan LiuAnuradha RebbapragadaSanja HuibnerJason BrunettaGraham SmithTatjana RekoRoberta HalpennyRupert KaulTroy GrennanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoojin Choi Mona Loutfy Robert S. Remis Juan Liu Anuradha Rebbapragada Sanja Huibner Jason Brunetta Graham Smith Tatjana Reko Roberta Halpenny Rupert Kaul Troy Grennan HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada
description	Abstract Men who have sex with men (MSM) are disproportionately affected by anal cancer, predominantly caused by high-risk (HR) human papillomavirus (HPV) infection. Currently, the nonavalent HPV vaccine provides coverage against nine HPV genotypes, including seven HR-HPV genotypes. Here, we characterize anal HR-HPV genotype distribution and associated risk factors in MSM from Toronto, Canada recruited between September 2010 and June 2012. Wilcoxon–Mann–Whitney test was used for continuous variables, Chi-square test was performed for categorical variables, and a multivariable model using logistic regression was created to assess for correlates of anal HR-HPV infection. A total of 442 MSM were recruited, with a median age of 45 (IQR 38–50) and an overall HPV prevalence of 82%. The prevalence of any HR-HPV infection was 65.3% and 50.7% in the HIV-positive and HIV-negative MSM, respectively. No participant tested positive for all genotypes covered by the nonavalent vaccine. HIV status (aOR 1.806; 95% CI 1.159–2.816), smoking (aOR 2.176; 95% CI 1.285–3.685) and the number of lifetime sexual partners (aOR 2.466; 95% CI 1.092–5.567) were independent risk factors for anal HR-HPV infection. Our findings will be useful to inform HPV vaccine rollout and HPV prevention strategies in Canadian MSM.
format	article
author	Yoojin Choi Mona Loutfy Robert S. Remis Juan Liu Anuradha Rebbapragada Sanja Huibner Jason Brunetta Graham Smith Tatjana Reko Roberta Halpenny Rupert Kaul Troy Grennan
author_facet	Yoojin Choi Mona Loutfy Robert S. Remis Juan Liu Anuradha Rebbapragada Sanja Huibner Jason Brunetta Graham Smith Tatjana Reko Roberta Halpenny Rupert Kaul Troy Grennan
author_sort	Yoojin Choi
title	HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada
title_short	HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada
title_full	HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada
title_fullStr	HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada
title_full_unstemmed	HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada
title_sort	hpv genotyping and risk factors for anal high-risk hpv infection in men who have sex with men from toronto, canada
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a8f2f8fba1bc486fa57b7c682b8e1f0b
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HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada

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