Neuropeptide system parameters in acute herpes zoster

The neuropeptides comprise an important part in the nervous system interacting with endocrine and immune systems. Peptide regulators are responsible for the continuity of communicating elements, which support homeostasis, however, despite abundant research examining neuropeptides, not all specific m...

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Autores principales:	S. V. Knysh, E. V. Markelova, A. I. Simakova, A. V. Karaulov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	neuropeptides herpes zoster shingles. s100 mpb ngf bdnf nse Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/a8f7b64192ed41168f988ce81aa127cb
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spelling	oai:doaj.org-article:a8f7b64192ed41168f988ce81aa127cb2021-11-22T07:09:54ZNeuropeptide system parameters in acute herpes zoster2220-76192313-739810.15789/2220-7619-TFO-1256https://doaj.org/article/a8f7b64192ed41168f988ce81aa127cb2020-05-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1256https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The neuropeptides comprise an important part in the nervous system interacting with endocrine and immune systems. Peptide regulators are responsible for the continuity of communicating elements, which support homeostasis, however, despite abundant research examining neuropeptides, not all specific mechanisms and features of interacting proteins with cells and immune components have been uncovered. Objective: to perform a comprehensive assessment of neuropeptide system in patients with herpes zoster. Materials and methods: 106 in-hospital patients were examined diagnosed with herpes zoster within 2016–2019 period. Control group consisted of 30 healthy age- and sex-matched volunteers. Blood serum was collected after verifying diagnosis on day 1. After discharge, patients were monitored for signs of pain syndrome and overall state within 3 months. It allowed to divide patients into 3 groups retrospectively. Group 1 — patients with herpes zoster, accompanied by mild or moderate pain syndrome; group 2 — patients with herpes zoster, accompanied by severe pain; group 3 — patients with herpes zoster, complicated by postherpetic neuralgia. Level of serum protein s100B, myelin basic protein, nerve growth factor, brain-derived neurotrophic factor, neuron specific enolase was measured by using specific reagents purchased from “R&D Diagnostics Inc.” (США). Results. it was found that level of serum protein S100B in all groups was significantly increased compared to control group, showing no inter-group differences. Amount of myelin basic protein in all study groups vs. control was significantly higher. Moreover, level of these parameters in group 2 vs. group 1 and 3 was significantly elevated. In addition, level of nerve growth factor was significantly increased in group 1 vs. groups 2 and 3, whereas in group 3 it was significantly lower than in control and group 2. Brain-derived neurotrophic factor was significantly decreased in all the study groups compared to control, showing no significant intergroup differences. Level of neuron-specific enolase was significantly increased in group 3 vs. control as well as group 1 and 2. The data obtained allowed to identify two parameters for assessing a risk of postherpetic neuralgia in acute herpes zoster, as well as provided deeper insights into the pathogenesis of neuroimmune disorders accompanying herpes zoster.S. V. KnyshE. V. MarkelovaA. I. SimakovaA. V. KaraulovSankt-Peterburg : NIIÈM imeni Pasteraarticleneuropeptidesherpes zostershingles. s100mpbngfbdnfnseInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 10, Iss 2, Pp 329-337 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	neuropeptides herpes zoster shingles. s100 mpb ngf bdnf nse Infectious and parasitic diseases RC109-216
spellingShingle	neuropeptides herpes zoster shingles. s100 mpb ngf bdnf nse Infectious and parasitic diseases RC109-216 S. V. Knysh E. V. Markelova A. I. Simakova A. V. Karaulov Neuropeptide system parameters in acute herpes zoster
description	The neuropeptides comprise an important part in the nervous system interacting with endocrine and immune systems. Peptide regulators are responsible for the continuity of communicating elements, which support homeostasis, however, despite abundant research examining neuropeptides, not all specific mechanisms and features of interacting proteins with cells and immune components have been uncovered. Objective: to perform a comprehensive assessment of neuropeptide system in patients with herpes zoster. Materials and methods: 106 in-hospital patients were examined diagnosed with herpes zoster within 2016–2019 period. Control group consisted of 30 healthy age- and sex-matched volunteers. Blood serum was collected after verifying diagnosis on day 1. After discharge, patients were monitored for signs of pain syndrome and overall state within 3 months. It allowed to divide patients into 3 groups retrospectively. Group 1 — patients with herpes zoster, accompanied by mild or moderate pain syndrome; group 2 — patients with herpes zoster, accompanied by severe pain; group 3 — patients with herpes zoster, complicated by postherpetic neuralgia. Level of serum protein s100B, myelin basic protein, nerve growth factor, brain-derived neurotrophic factor, neuron specific enolase was measured by using specific reagents purchased from “R&D Diagnostics Inc.” (США). Results. it was found that level of serum protein S100B in all groups was significantly increased compared to control group, showing no inter-group differences. Amount of myelin basic protein in all study groups vs. control was significantly higher. Moreover, level of these parameters in group 2 vs. group 1 and 3 was significantly elevated. In addition, level of nerve growth factor was significantly increased in group 1 vs. groups 2 and 3, whereas in group 3 it was significantly lower than in control and group 2. Brain-derived neurotrophic factor was significantly decreased in all the study groups compared to control, showing no significant intergroup differences. Level of neuron-specific enolase was significantly increased in group 3 vs. control as well as group 1 and 2. The data obtained allowed to identify two parameters for assessing a risk of postherpetic neuralgia in acute herpes zoster, as well as provided deeper insights into the pathogenesis of neuroimmune disorders accompanying herpes zoster.
format	article
author	S. V. Knysh E. V. Markelova A. I. Simakova A. V. Karaulov
author_facet	S. V. Knysh E. V. Markelova A. I. Simakova A. V. Karaulov
author_sort	S. V. Knysh
title	Neuropeptide system parameters in acute herpes zoster
title_short	Neuropeptide system parameters in acute herpes zoster
title_full	Neuropeptide system parameters in acute herpes zoster
title_fullStr	Neuropeptide system parameters in acute herpes zoster
title_full_unstemmed	Neuropeptide system parameters in acute herpes zoster
title_sort	neuropeptide system parameters in acute herpes zoster
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/a8f7b64192ed41168f988ce81aa127cb
work_keys_str_mv	AT svknysh neuropeptidesystemparametersinacuteherpeszoster AT evmarkelova neuropeptidesystemparametersinacuteherpeszoster AT aisimakova neuropeptidesystemparametersinacuteherpeszoster AT avkaraulov neuropeptidesystemparametersinacuteherpeszoster
_version_	1718417935823798272

Neuropeptide system parameters in acute herpes zoster

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